Stroke-like pattern in DTI and MRS of childhood mitochondrial leukoencephalopathy

Neuroradiology

Volumn 46, Issue 4, 2004, Pages 267-271

  Brockmann, K ^a,d   Finsterbusch, J ^b   Schara, U ^c   Wilchowski, E ^a   Frahm, J ^b   Hanefeld, F ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b Biomedizinische NMR Forschungs GmbH   (Germany)

^c RUHR UNIVERSITY BOCHUM   (Germany)

^d Department of Pediatrics and Neuropediatrics   (Germany)

Author keywords

Apparent diffusion coefficient; Diffusion tensor imaging; Leukoencephalopathy; MRS; Oxidative phosphorylation

Indexed keywords

LACTIC ACID;

ANISOTROPY; ARTICLE; CASE REPORT; CEREBROSPINAL FLUID LEVEL; CHILDHOOD DISEASE; DIAGNOSTIC IMAGING; DIFFUSION COEFFICIENT; DIFFUSION TENSOR IMAGING; FEVER; FOLLOW UP; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; MALE; METABOLITE; MITOCHONDRIAL ENCEPHALOMYOPATHY; MOTOR DYSFUNCTION; MUSCLE BIOPSY; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RECURRENT DISEASE; STROKE; VASTUS LATERALIS MUSCLE;

ANISOTROPY; DIFFUSION MAGNETIC RESONANCE IMAGING; HUMANS; INFANT; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MITOCHONDRIAL ENCEPHALOMYOPATHIES; REMISSION, SPONTANEOUS;

EID: 2342481770     PISSN: 00283940     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00234-004-1181-7     Document Type: Article

References (10)

1. Frahm J, Hanefeld F (1996) Localized proton magnetic resonance spectroscopy of cerebral metabolites. Neuropediatrics 27:64-69
2. Pouwels PJ, Brockmann K, Kruse B et al. (1999) Regional age dependence of human brain metabolites from infancy to adulthood as detected by quantitative localized proton MRS. Pediatr Res 46:474-485
3. Nolte U, Finsterbusch J, Frahm J (2000) Rapid isotropic diffusion mapping without susceptibility artifacts. Whole brain studies using diffusion-weighted single-shot STEAM MR imaging. Magn Reson Med 44:731-736
4. Pierpaoli C, Basser PJ (1996) Toward a quantitative assessment of diffusion anisotropy. Magn Reson Med 36:893-906
5. Engelbrecht V, Scherer A, Rassek M et al. (2002) Diffusion-weighted MR imaging in the brain of children: findings in normal brain and in the brain with white matter diseases. Radiology 222:410-418
6. Sener RN (2002) Metachromatic leukodystrophy: diffusion MR imaging findings. Am J Neuroradiol 23:1424-1426
7. Phillips MD, McGraw P, Lowe MJ et al. (2001) Diffusion-weighted imaging of white matter abnormalities in patients with phenylketonuria. Am J Neuroradiol 22:1583-1586
8. Majoie CB, Akkerman EM, Blank C et al. (2002) Mitochondrial encephalomyopathy: comparison of conventional MR imaging with diffusion-weighted and diffusion tensor imaging: case report. Am J Neuroradiol 23:813-816
9. Lansberg MG, Thijs VN, O'Brien MW et al. (2001) Evolution of apparent diffusion coefficient, diffusion-weighted, and T2-weighted signal intensity of acute stroke. Am J Neuroradiol 22:637-644
10. Wardlaw JM, Marshall I, Wild J et al. (1998) Studies of acute ischemic stroke with proton magnetic resonance spectroscopy: relation between time from onset, neurological deficit, metabolite abnormalities in the infarct, blood flow, and clinical outcome. Stroke 29:1618-1624