Acute toxicity of binary mixture benzene-ethanol and partition coefficient KOW of benzene and ethanol

Central European Journal of Public Health

Volumn 12, Issue SUPPL., 2004, Pages

  Rucki, M ^a   Tichy M ^a  

^a NATIONAL INSTITUTE OF PUBLIC HEALTH   (Czech Republic)

Author keywords

Binary mixture; Mixture toxicity; Octanol water; Partition coefficient

Indexed keywords

ALCOHOL; BENZENE; OCTANOL; WATER;

ACUTE TOXICITY; CONFERENCE PAPER; PARTITION COEFFICIENT; STATISTICAL ANALYSIS; STATISTICAL MODEL;

ANIMALS; BENZENE; ETHANOL; OLIGOCHAETA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 2342472010     PISSN: 12107778     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (13)

1. Leo A, Hansch C, Elkins D: Partition coefficients and their uses. Chem Rev 1971; 71: 525-615.
2. Leo A, Hansch C: Linear free-energy relationships between partitioning solvent systems. J Org Chem 1971; 36: 1539-1544.
3. Tichý M: Effectiveness of xenobiotics and chemical structure. Praha (CZ): Avicenum; 1983. (In Czech.)
4. Hansch C, Maloney PP, Fujita T, Muir RM: Correlation of biological activity of phenoxyacetic acids with Hammett substituent constants and partition coefficients. Nature 1962; 194: 178-180.
5. Hansch C, Muir RM, Fujita T, Maloney PP, Geiger CF, Streich M: The correlation of biological activity of plant growth regulators and chloromycetin derivatives with Hammett constants and partition coefficients. J Amer Chem Soc 1963; 85: 2817-2824.
6. Hansch C, Fujita T: ρ-σ-π Analysis. A method for the correlation of biological activity and chemical structure. J Amer Chem Soc 1964; 86: 1616-1626.
7. U.S. Environmental Protection Agency: Toxic Substance Control-Discussion of Premanufacture Testing Policy and Technical Issues, Request for Comment, Fed Regist, 44 (53), 16253-54 (16 March 1979).
8. Tichý M, Rucki M, Borěk-Dohalský V, Feltl L: Partition coefficients of binary mixtures of chemicals: possibility for the QSAR analysis. In: Gundertoffe K, Jørgensen FS, editors. Molecular Modeling and Prediction of Bioactivity. New York: Kluwer Academic/Plenum Publisher; 2000. p. 311-313.
9. Tichý M, Bořek-Dohalský V, Matoušová D, Rucki M, Feltl L, Roth Z: Prediction of acute toxicity of chemicals in mixtures: worms Tubifex tubifex and gas/liquid distribution. SAR QSAR Environ Res 2002; 13: 261-269.
10. U.S. Environmental Protection Agency: Determination of Octanol/Water Distribution Coefficients, Water Solubilities, and Sediment/Water Partition Coefficients for Hydrophobic Organic Pollutants, EPA-600/4-79-032, (U.S. EPA 1979).
11. Carlson RM, Carlson RE, Kopperman H: Determination of partition coefficients by liquid chromatography. J Chromatogr 1975; 107: 219-223.
12. Rucki M, Tichý M: Octanol/water partition coefficient and acute toxicity of binary mixture benzene-ethanol. In: Romančik V, Koprda V, editors. Industrial toxicology 92. Bratislava: Slovak Association for Industrial Toxicology; 2002. p. 94-97. ISBN 80-968011-4-7.
13. Tichý M, Rucki M: Alternative method for the determination of acute toxicity of chemicals: inhibition of movement of the worms Tubifex tubifex. Prac Lék 1996; 48: 249-263. (In Czech.)