Cadmium-induced nephropathy in rats is mediated by expression of senescence-associated beta-galactosidase and accumulation of mitochondrial DNA deletion

Annals of the New York Academy of Sciences

Volumn 1011, Issue , 2004, Pages 332-338

  Takaki, Aya ^a   Jimi, Shiro ^a   Segawa, Masaru ^a   Iwasaki, Hiroshi ^a  

^a FUKUOKA UNIVERSITY   (Japan)

Author keywords

Chronic cadmium intoxication; Mitochondrial DNA deletion; Senescence

Indexed keywords

BETA GALACTOSIDASE; MITOCHONDRIAL DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ATOMIC ABSORPTION SPECTROMETRY; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA EXTRACTION; ENZYME ACTIVITY; FEMALE; GENE AMPLIFICATION; GENE DELETION; GENE EXPRESSION; HISTOCHEMISTRY; KIDNEY DISEASE; NONHUMAN; RAT; SENESCENCE;

ANIMALIA; RATTUS NORVEGICUS;

EID: 2342471810     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1293.033     Document Type: Conference Paper

References (13)

1. SVARTENGREN, M., C.G. ELINDER, L. FRIBERG & B. LIND. 1986. Distribution and concentration of cadmium in human kidney. Environ. Res. 39: 1-7.
2. TAKEBAYASHI, S., S. JIMI, M. SEGAWA & Y. KIYOSHI. 2000. Cadmium induces osteomalacia mediated by proximal tubular atrophy and disturbances of phosphate reabsorption. A study of 11 autopsies. Pathol. Res. Pract. 196: 653-663.
3. WALLANCE, D.C. 1999. Mitochondrial diseases in man and mouse. Science 283: 1482-1488.
4. LARSSON, N.G. & D.A. CLAYTON. 1995. Molecular genetic aspect of human mitochondria disorders. Annu. Rev. Genet. 29: 151-178.
5. CORTOPASSI, G.A. & N. ARNHEIM. 1990. Detection of a specific mitochondrial DNA deletion in tissues of older individuals. Nucleic Acids Res. 18: 6927-6933.
6. CORRAL-DEBRINSKI, M., T. HORTON, M.T. LOTT, et al. 1992. Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nature Genet. 2: 324-329.
7. ZHANG, C., A. BAUMER, R.J. MAXWELL, et al. 1992. Multiple mitochondrial DNA deletions in an elderly human individual. FEBS Lett. 297: 34-38.
8. GADALETA, M.N., G. RAINALDI, A.M. LEZZA, et al. 1992. Mitochondrial DNA copy number and mitochondrial DNA deletion in adult and senescent rats. Mutat. Res. 275: 181-193.
9. FILSER, N., C. MARGUE & C. RICHTER. 1997. Quantification of wild-type mitochondrial DNA and its 4.8-kb deletion in rat organs. Biochem. Biophys. Res. Commun. 233: 102-107.
10. YOWE, D.L. & B.N. AMES. 1998. Quantitation of age-related mitochondrial DNA deletions in rat tissues shows that their pattern of accumulation differs from that of humans. Gene 209: 23-30.
11. MORACZEWSKI, A. & R.C. ANDERSON. 1966. The determination by quantitative histochemistry of the effect of phenothiazines on brain cytochrome c oxidase activity. J. Histochem. Cytochem. 14: 64-76.
12. CHOI, J., I. SHENDRIK, M. PEACOCKE, et al. 2000. Expression of senescence-associated beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia. Urology 56: 160-166.
13. DIMRI, G.P., X. LEE, G. BASILE, et al. 1995. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA 92: 9363-9367.