Hemolytic uremic syndrome induced by lipopolysaccharide and Shiga-like toxin

Pediatric Nephrology

Volumn 19, Issue 5, 2004, Pages 485-489

  Ikeda, Masahiro ^a,b   Ito, Shuichi ^a   Honda, Masataka ^a  

^a TOKYO METROPOLITAN CHILDREN'S MEDICAL CENTER   (Japan)

^b NONE   (Japan)

Author keywords

C3H HeN mice; Globotriosyl ceramide; Hemolytic uremic syndrome; Lipopolysaccharide; Shiga toxin

Indexed keywords

LIPOPOLYSACCHARIDE; VEROTOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; GLOMERULUS; HEMATURIA; HEMOLYTIC UREMIC SYNDROME; HISTOPATHOLOGY; KIDNEY DYSFUNCTION; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEINURIA; RODENT; THROMBOCYTOPENIA;

ANIMALS; HEMOLYTIC-UREMIC SYNDROME; KIDNEY GLOMERULUS; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C3H; MICROSCOPY, ELECTRON; PLATELET COUNT; SHIGA TOXIN;

EID: 2342452514     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-003-1395-7     Document Type: Article

References (13)

1. Karmali MA, Petric M, Lim C, Fleming DC, Arbus GS, Lior H (1985) The association between idiopathic hemolytic uremic syndrome and infection by verotoxin-producing Escherichia coli. J Infect Dis 151:775-782
2. Taylor FB Jr, Tesh VL, DeBault L, Li A, Chang AC, Kosanke SD, Pysher TJ, Siegler RL (1999) Characterization of the baboon responses to Shiga-like toxin: descriptive study of a new primate model of toxic responses to Stx-1. Am J Pathol 154:1285-1299
3. Barrett TJ, Potter ME, Wachsmuth IK (1989) Bacterial endotoxin both enhances and inhibits the toxicity of Shiga-like toxin 2 in rabbits and mice. Infect Immun 57:3434-3437
4. Bertani T, Abbate M, Zoja C, Corna D, Remuzzi G (1989) Sequence of glomerular changes in experimental endotoxemia: a possible model of hemolytic uremic syndrome. Nephron 53:330-337
5. Karpman D, Connell H, Svensson M, Scheutz F, Alm P, Svanborg C (1997) The role of lipopolysaccharide and Shiga-like toxin in a mouse model of Escherichia coli O157:H7 infection. J Infect Dis 175:611-620
6. Zhang H, Peterson JW, Niesel DW, Klimpel GR (1997) Bacterial lipoprotein and lipopolysaccharide act synergistically to induce lethal shock and proinflammatory cytokine production. J Immunol 159:4868-4878
7. Tesh VL, Burris JA, Owens JW, Gordon VM, Wadolkowski EA, O'Brien AD, Samuel JE (1993) Comparison of the relative toxicities of Shiga-like toxins type 1 and type 2 for mice. Infect Immun 61:3392-3402
8. Palermo M, Alves-Rosa F, Rubel C, Fernandez GC, Fernandez-Alonso G, Alberto F, Rivas M, Isturiz M (2000) Pretreatment of mice with lipopolysaccharide (LPS) or IL-1beta exerts dose-dependent opposite effects on Shiga toxin-2 lethality. Clin Exp Immunol 119:77-83
9. Newburg DS, Chaturvedi P, Lopez L, Devoto.S, Fayad A, Cleary TG (1993) Susceptibility to hemolytic-uremic syndrome relates to erythrocyte glycosphingolipid patterns. J Infect Dis 168:476-479
10. Loo DM te, Monnens LA, Velden TJ van der, Vermeer MA, Preyers F, Demacker PN, Heuvel LP van den, Hinsbergh VW van (2000) Binding and transfer of verocytotoxin by polymorphonuclear leukocytes in hemolytic uremic syndrome. Blood 95:3396-3402
11. Setten PA van, Monnens LAH, Verstraten RGG, Heuvel LPWJ van den, Hinsbergh VWM van (1996) Effects of verocytotoxin-1 on nonadherent human monocytes: binding characteristics, protein synthesis, and induction of cytokine release. Blood 88:174-183
12. Kaplan BS, Cleary TG, Obrig TG (1990) Recent advances in understanding the pathogenesis of the hemolytic uremic syndromes. Pediatr Nephrol 4:276-283
13. Turi S, Nemeth I, Vargha I, Matkovics B (1994) Oxidative damage of red blood cells in haemolytic uraemic syndrome. Pediatr Nephrol 8:26-29