Quantitative structure toxicity relationships for catechols in isolated rat hepatocytes

Chemico-Biological Interactions

Volumn 147, Issue 3, 2004, Pages 297-307

  Moridani, Majid Y ^a,b   Siraki, Arno ^a   Chevaldina, Tatiana ^a   Scobie, Hugh ^a   O'Brien, Peter J ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

3 (N morpholino)propanesulfonic acid; Catechols; DETAPAC; diethylenetriaminopenta acetic acid; Hepatocyte; MOPS; QSAR; QSTR; quantitative structure activity relationship; quantitative structure toxicity relationship; Structure activity relationship

Indexed keywords

2,3 DIHYDROXYBENZALDEHYDE; 3 METHOXYCATECHOL; 3,4 DIHYDROXYBENZONITRILE; 3,4 DIHYDROXYPHENYLACETIC ACID; 3,5 BIS TERT BUTYLCATECHOL; 4 HYDROXYCHAVICOL; 4 METHOXYCATECHOL; 4 METHYLCATECHOL; 4 N PROPYLCATECHOL; 4 NITROCATECHOL; 4 TERT BUTYLCATECHOL; ANTINEOPLASTIC AGENT; CAFFEIC ACID; CATECHOL; CATECHOL DERIVATIVE; CHLOROGENIC ACID; DIHYDROCAFFEIC ACID; DOPAMINE; LEVODOPA; NORDIHYDROQUAIARETIC ACID; OCTANOL; PHENOL; PROTOCATECHUALDEHYDE; PROTOCATECHUIC ACID; PYROGALLOL; TETRACHLOROCATECHOL; UNCLASSIFIED DRUG; WATER;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXICITY; IONIZATION; LD 50; LETHAL DOSE; LIPOPHILICITY; LIVER CELL; MATHEMATICAL COMPUTING; NONHUMAN; PARTITION COEFFICIENT; PH MEASUREMENT; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; STATISTICAL ANALYSIS;

ANIMALS; CATECHOLS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATOCYTES; LETHAL DOSE 50; MALE; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY;

EID: 2342451233     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2004.02.001     Document Type: Article

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