Colonic epithelial cell mediated suppression of CD4 T cell activation

Gut

Volumn 53, Issue 5, 2004, Pages 678-684

  Cruickshank, S M ^a   McVay, L D ^b   Baumgart, D C ^c   Felsburg, P J ^b   Carding, S R ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD45 ANTIGEN; CD86 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 2 RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; CELL ACTIVATION; CELL CONTACT; CELL CULTURE; CELL CYCLE G1 PHASE; COCULTURE; COLON MUCOSA; EPITHELIUM CELL; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUPPRESSOR CELL; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD; CD4-POSITIVE T-LYMPHOCYTES; CELL COMMUNICATION; CELLS, CULTURED; CLONAL ANERGY; COCULTURE TECHNIQUES; COLON; EPITHELIAL CELLS; EPITOPES; IMMUNE TOLERANCE; IMMUNITY, MUCOSAL; INTESTINAL MUCOSA; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC;

EID: 2342428651     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2003.029967     Document Type: Article

References (31)

1. Shao L, Serrano D, Mayer L. The role of epithelial cells in immune regulation in the gut. Semin Immunol 2001;13:163-76.
2. Mayer L, Eisenhardt D, Salomon P, et al. Expression of class II molecules on intestinal epithelial cells in humans. Differences between normal and inflammatory bowel disease. Gastroenterology 1991;1191:100-3.
3. Hershberg RM, Cho DH, Youakim A, et al. Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells. J Clin Invest 1998;102:792-803.
4. Blumberg RS, Lencer WI, Zhu X, et al. Antigen presentation by intestinal epithelial cells. Immunol Lett 1999;69:7-11.
5. Campbell N, Yio XY, So LP, et al. The intestinal epithelial cell: processing and presentation of antigen to the mucosal immune system. Immunol Rev 1999;172:315-24.
6. Mayer L, Blumberg RS. Antigen presenting cells; Epithelial cells. In:Ogra PL, Mestecky J, Lamm ME, et al, editors. Mucosal immunology. San Diego: Academic Press, 1999:365-379.
7. Garside P, Mowat AM. Oral tolerance. Semin Immunol 2001;13:177-85.
8. Strober W, Fuss IJ, Blumberg RS. The immunology of mucosal models of inflammation. Ann Rev Immunol 2002;20:495-549.
9. Kato T, Owen RL. Structure and function of intestinal mucosal epithelium. In:Ogra PL, Mestecky J, Lamm ME, et al, editors. Mucosal immunology. San Diego: Academic Press, 1999:115-32.
10. Telega GW, Baumgart DC, Carding SR. Uptake and presentation of antigen to T cells by primary colonic epithelial cells in normal and diseased states. Gastroenterology 2000;119:1548-59.
11. Carrena BM, Collins M. The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Ann Rev Immunol 2002;20:29-53.
12. Leon M, Kirby J, Gibbs P, et al. Immunogenicity of biliary epithelial cells: study of the expression of B7 molecules. J Hepatol 1995;22:591-6.
13. Ye G, Barrera C, Fan X, et al. Expression of B7-1 and B7-2 costimulatory molecules by human gastric epithelial cells: potential role in CD4+ T cell activation during Helicobacter pylori infection. J Clin Invest 1997;99:1628-36.
14. Cruickshank SM, Southgate J, Selby PJ, et al. Expression and cytokine regulation of immune recognition elements by normal human biliary epithelial and established liver cell lines in vitro. J Hepatol 1998;29:550-8.
15. Leon MP, Bassendine MF, Wilson JL, et al. Immunogenicity of biliary epithelium: Investigation of antigen presentation to CD4+ T cells. Hepatology 1996;24:561-7.
16. Cunningham AC, Zhang IG, May JV, et al. A comparison of the antigen-presenting capabilities of class II MHC-expressing human lung epithelial and endothelial cells. Immunology 1997;91:458-63.
17. Cruickshank SM, Southgate J, Selby PJ, et al. Inhibition of T cell activation by normal human biliary epithelial cells. J Hepatol 1999;31:1026-33.
18. Spengler U, Leifeld L, Braunschweiger I, et al. Anomalous expression of costimulatory molecules B7-1, B7-2 and CD28 in primary biliary cirrhosis. J Hepatol 1997;26:31-6.
19. Nakazawa A, Watanabe M, Kanoi T, et al. Functional expression of costimulatory molecule CD86 on epithelial cells in the inflamed colonic mucosa. Gastroenterology 1999;117:536-45.
20. Baumgart DC, Olivier WA, Reya T, et al. Mechanisms of intestinal epithelial cell injury and colitis in interleukin 2 (IL2)-deficient mice. Cell Immunol 1998;187:52.
21. Ebert EC. Proliferative responses of human intraepithelial lymphocytes to various T-cell stimuli. Gastroenterology 1989;97:1372-81.
22. Sanderson S, Shastri N. LacZ-inducible, antigen/MHC specific T cell hybrids. Int Immunol 1994;6:369-76.
23. Bland PW, Warren LG. Antigen presentation by epithelial cells of the rat small intestine. I. Kinetics, antigen specificity and blocking by anti-lo antisera. Immunology 1986;58:1-7.
24. Arosa FA, Irwin C, Mayer L, et al. Interactions between peripheral blood CD8 T lymphocytes and intestinal epithelial cells (iEC). Clin Exp Immunol 1998;112:226-36.
25. Allez M, Brimnes J, Dotan I, et al. Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells. Gastroenterology 2002;123:1516-26.
26. Bland PW, Warren LG. Antigen presentation by epithelial cells of the rat small intestine. II. Selective induction of suppressor T cells. Immunology 1986;58:9-14.
27. Nakamura K, Kitani A, Strober W. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med 2001;194:629-44.
28. Chang JF, Zhao HL, Phillips J, et al. The epithelial mucin, MUC1, is expressed on resting T lymphocytes and can function as a negative regulator of T cell activation. Cell Immunol 2000;201:83-8.
29. Gimmi CD, Morrison BW, Mainprice BA, et al. Breast cancer-associated antigen, DF3/MUC1, induces apoptosis of activated human T cells. Nature Med 1996;2:1367-70.
30. Zang X, Loke P, Kim J, et al. B7x: A widely expressed B7 family member that inhibits T cell activation. Proc Natl Acad Sci U S A 2003;100:10388-92.
31. Loke P, Allison JP. PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells. Proc Natl Acad Sci U S A 2003;100:5336-41.