Acute hypoxia increases S100β protein in association with blood flow redistribution away from peripheral circulations in fetal sheep

Pediatric Research

Volumn 58, Issue 2, 2005, Pages 179-184

  Giussani, Dino A ^a,b   Thakor, Avnesh S ^a   Frulio, Rosanna ^c,d   Gazzolo, Diego ^c,d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Lister Institute of Preventive Medicine   (United Kingdom)

^c G GASLINI INSTITUTE   (Italy)

^d GARIBALDI HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BICARBONATE; BIOCHEMICAL MARKER; PROTEIN S100B;

ACID BASE BALANCE; ACIDEMIA; ANIMAL MODEL; ARTERIAL CARBON DIOXIDE TENSION; ARTERIAL OXYGEN TENSION; ARTERIAL PH; ARTERIAL PRESSURE; ARTICLE; BLOOD FLOW REDISTRIBUTION; BLOOD VESSEL CATHETERIZATION; FEMORAL ARTERY; FETUS; FETUS CIRCULATION; FETUS HYPOXIA; HEART RATE; HEMODYNAMICS; HYPOXEMIA; NONHUMAN; PERINATOLOGY; PERIPHERAL CIRCULATION; PREGNANCY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SHEEP; TRANSDUCER; UMBILICAL ARTERY; VASCULAR RESISTANCE;

ANIMALS; ANOXIA; CALIBRATION; FETAL BLOOD; HEMODYNAMIC PROCESSES; HEMOGLOBINS; HYDROGEN-ION CONCENTRATION; NERVE GROWTH FACTORS; OXYGEN; PRESSURE; REGIONAL BLOOD FLOW; S100 PROTEINS; SHEEP; TIME FACTORS; UMBILICAL VEINS;

EID: 23244466423     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.PDR.0000169999.66157.C0     Document Type: Article

References (26)

1. Heizmann CW 1999 Calcium-binding proteins in the central nervous system. Neurochem Res 24:1097-1100
2. Michetti F, Gazzolo D 2002 S100B protein in biological fluids: a tool in perinatal medicine. Clin Chem 48:2097-2104
3. Jonsson H, Johnsson P, Hoglund P, Alling C, Blomquist S 2000 Elimination of S100B and renal function after cardiac surgery. J Cardiothorac Vasc Anesth 14:698-701
4. Michetti F, Massaro A, Murazio M 1979 The nervous system-specific S-100 antigen in cerebrospinal fluid of multiple sclerosis patients. Neurosci Lett 11:71-75
5. Michetti F, Massaro A, Russo G, Rigon G 1980 The S-100 antigen in cerebrospinal fluid as a possible index of cell injury in the nervous system. J Neurol Sci 44:259-263
6. Johnsson P, Lundquist C, Lindgren A, Ferencz I, Alling C, Stahl E 1995 Cerebral complications after cardiac surgery assessed by S100 and NSE levels in blood. J Cardiothorac Vasc Anesth 9:694-699
7. Persson L, Hardemark HG, Gustafsson J, Rundstrom G, Mendel-Hartvig I, Esscher T, Pahlman S 1987 S-100 protein and neuron-specific enolase in cerebrospinal fluid and serum: markers of cell damage in human central nervous system. Stroke 18:911-918
8. Gazzolo D, Vinesi P, Geloso MC, Marcelletti CF, Iorio FS, Marianeschi SM, Michetti F 1998 S100 blood concentrations in children subjected to cardiopulmonary by-pass. Clin Chem 44:1058-1060
9. Gazzolo D, Di Iorio R, Marinoni E, Masetti P, Serra G, Giovannini L, Michetti F 2002 S100B Protein is increased in asphyxiated term infants developing intraventricular hemorrhage. Crit Care Med 30:1356-1360
10. Gazzolo D, Marinoni E, Di Iorio R, Lituania M, Bruschettini PL, Michetti F 2002 Circulating S100B protein is increased in intrauterine growth-retarded fetuses. Pediatr Res 51:215-219
11. Giussani DA, Spencer JA, Moore PJ, Bennet L, Hanson MA 1993 Afferent and efferent components of the cardiovascular reflex responses to acute hypoxia in term fetal sheep. J Physiol 461:431-449
12. Thorngren-Jerneck K, Alling C, Herbst A, Amer-Wahlin I, Marsal K 2004 S100 protein in serum as a prognostic marker for cerebral injury in term newborn infants with hypoxic ischemic encephalopathy. Pediatr Res 55:406-412
13. Gardner DS, Giussani DA 2003 Enhanced umbilical blood flow during acute hypoxemia after chronic umbilical cord compression: a role for nitric oxide. Circulation 108:331-335
14. Giussani DA, Spencer JA, Hanson MA 1994 Fetal cardiovascular reflex responses to hypoxaemia. Fetal Matern Med Rev 6:17-37
15. Rudolph AM 1984 The fetal circulation and its response to stress. J Dev Physiol 6:11-19
16. van Bel F, Sola A, Roman C, Rudolph AM 1995 Role of nitric oxide in the regulation of the cerebral circulation in the lamb fetus during normoxemia and hypoxemia. Biol Neonate 68:200-210
17. Jones CT, Robinson RO 1975 Plasma catecholamines in foetal and adult sheep. J Physiol 248:15-33
18. Green LR, Bennet L, Hanson MA 1996 The role of nitric oxide synthesis in cardiovascular responses to acute hypoxia in the late gestation sheep fetus. J Physiol 497:271-277
19. Harris AP, Helou S, Gleason CA, Traystman RJ, Koehler RC 2001 Fetal cerebral and peripheral circulatory responses to hypoxia after nitric oxide synthase inhibition. Am J Physiol 281:R381-R390
20. Morrison S, Gardner DS, Fletcher AJ, Bloomfield MR, Giussani DA 2003 Enhanced nitric oxide activity offsets peripheral vasoconstriction during acute hypoxaemia via chemoreflex and adrenomedullary actions in the sheep fetus. J Physiol 547:283-391
21. Akalin-Sel T, Campbell S 1992 Understanding the pathophysiology of intra-uterine growth retardation: the role of the 'lower limb reflex' in redistribution of blood flow. Eur J Obstet Gynecol Reprod Biol 23:79-86
22. Hu J, Ferreira A, Van Eldik LJ 1997 S100β induces neuronal cell death through nitric oxide release from astrocytes. J Neurochem 69:2294-2301
23. Wigglesworth JS, Pape KE 1978 An integrated model for haemorrhagic and ischaemic lesions in the newborn brain. Early Hum Dev 2:179-199
24. Gazzolo D, Marinoni E, Di Iorio R, Bruschettini M, Kornacka M, Lituania M, Majewska U, Serra G, Michetti F 2004 Urinary S100B protein measurements: a tool for the early identification of hypoxic-ischemic encephalopathy in asphyxiated full-term infants. Crit Care Med 32:131-136
25. Marinoni E, Di Iorio R, Gazzolo D, Lucchini C, Michetti F, Corvino V, Cosmi EV 2002 Ontogenic localization and distribution of S-100β protein in human placental tissues. Obstet Gynecol 99:1093-1099
26. Wijnberger LD, Nikkels PG, van Dongen AJ, Noorlander CW, Mulder EJ, Schrama LH, Visser GH 2002 Expression in the placenta of neuronal markers for perinatal brain damage. Pediatr Res 51:492-496