Synthetic studies toward pondaplin: Total synthesis of pondaplin analogues

Tetrahedron Letters

Volumn 46, Issue 36, 2005, Pages 6145-6148

  Sabitha, Gowravaram ^a   Swapna, R ^a   Satheesh Babu, R ^a   Yadav, J S ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Analogues; Dimer; Keck macrolactonization; Pondaplin

Indexed keywords

ANTINEOPLASTIC AGENT; BENZENE DERIVATIVE; MACROLIDE; PONDAPLIN; PONDAPLIN DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; CYCLIZATION; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; MACROLACTONIZATION; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; RING CLOSING METATHESIS;

EID: 23244436088     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2005.06.145     Document Type: Article

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17. 2), 5.65 (t, 1H, J = 6.8 Hz), 5.82 (d, 1H, J = 12.6 Hz), 6.82 (d, 2H, J = 8.9 Hz, ArH), 6.92 (d, 1H, J = 12.6 Hz), 7.66 (d, 2H, J = 8.9 Hz, ArH).
18. 3): δ 166.0, 160.2, 143.3, 137.6, 127.5, 127.2, 122.6, 119.6, 114.0, 68.5, 65.8, 20.3. FAB Mass: 461 (M+1).
19. Q. Cheng, Y.W. Zhang, X. Zhang, and T. Oritani Chin. Chem. Lett. 14 2003 1215 1218
20. 2), 5.72 (t, 1H, J = 6.8 Hz), 6.98 (d, 2H, J = 8.9 Hz, ArH), 7.82 (d, 2H, J = 8.9 Hz, ArH), 9.89 (s, 1H, -CHO).
21. 3): 167.29, 160.3, 144.1, 140.9, 129.6, 127.4, 122.2, 115.9, 115.0, 64.0, 61.9, 60.3, 21.3, 14.3; FAB Mass: 277 (M+1).
22. 3): δ 173.2, 157.0, 139.7, 132.5, 129.0, 119.8, 114.5, 70.8, 67.4, 35.7, 29.9, 19.3; FAB Mass: 233 (M+1).
23. 3): δ 173.2, 157.0, 137.7, 132.5, 129.0, 119.8, 114.5, 75.1, 67.4, 35.7, 29.9, 13.7; FAB Mass: 233 (M+1).