The stabilization and release of hirudin from liposomes or lipid-assemblies coated with hydrophobically modified dextran

AAPS PharmSciTech

Volumn 1, Issue 1, 2000, Pages

  Mumper, Russell J ^a   Hoffman, Allan S ^b  

^a University of Kentucky   (United States)

^b University of Washington   (United States)

Author keywords

Dextran; Hirudin; In vitro release; Liposomes; Stabilization; Thrombin; Vascular graft

Indexed keywords

CHROMOGENIC SUBSTRATE; DEXTRAN; HIRUDIN; LIPID; LIPOSOME; PALMITIC ACID; THROMBIN; DEXTRAN PHOSPHATE; DRUG CARRIER; HIRUDIN DERIVATIVE; PALMITIC ACID DERIVATIVE;

ARTICLE; BLOOD VESSEL GRAFT; CHEMICAL MODIFICATION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DIALYSIS MEMBRANE; DRUG ACTIVITY; DRUG COATING; DRUG ELIMINATION; DRUG HALF LIFE; DRUG POTENCY; DRUG RELEASE; DRUG STABILITY; HYDROPHOBICITY; IN VITRO STUDY; INHIBITION KINETICS; SUSTAINED DRUG RELEASE; TIME; ARTIFICIAL MEMBRANE; CHEMISTRY; DRUG ANTAGONISM; LIPID METABOLISM; METABOLISM; MOLECULAR WEIGHT;

DEXTRANS; DRUG CARRIERS; DRUG STABILITY; HIRUDINS; HYDROPHOBICITY; LIPID METABOLISM; LIPIDS; LIPOSOMES; MEMBRANES, ARTIFICIAL; MOLECULAR WEIGHT; PALMITIC ACIDS; THROMBIN;

EID: 23144458911     PISSN: 15309932     EISSN: 15309932     Source Type: Journal    
DOI: 10.1007/bf02830518     Document Type: Article

References (20)

1. Fenton, JW. Thrombin Interaction with Hirudin. Seminars in Thrombosis and Hemostasis. 1989;15:265-268.
2. Markwardt, F. Hirudin and Derivatives as Anticoagulant Agents. Thrombosis and Haemostasis. 1991;66:141-152 (1991).
3. DiMaio, J, Gibbs, B, Munn, D, Lefebvre, J, Ni, F, Konishi, Y. Bifunctional Thrombin Inhibitors Based on the Sequence of Hirudin. J Biol Chem. 1990;265:21,698-21,703.
4. Markwardt, F, Richter, M, Walsmann, P, Riesener, G, Paintz, M. Preparation of Dextran-bound Recombinant Hirudin and its Pharmacokinetic Behaviour. Biomed Biochim Acta, 1990;49:1103-1108.
5. Ku, CSL, Bornstein, L, Breillatt, J, Ung-Chhun, SN, Johnson, R, Lindon, J, Pokropinski, S, Rimer, D. Development of Thromboresistant Biomaterials: Immobilization of Hirudin onto Polymers. The 17th Annual Meeting of the Society for Biomaterials. May, 1991, Scottsdale, Arizona.
6. Niada, R. Oral Pharmaceutical Compositions Containing Hirudin. European Patent Application Number 91111733.1. Publication Number EP 0468327A2. July, 1991.
7. Akiyoshi, K, Nishikawa, T, Nagai, K, Deguchi, S, Sunamoto, J. Self-Aggregate of Hydrophobized Polysaccharide Expected as a Drug Carrier. Proceed Intern Symp Control Rel Bioact Mater. 1992;19:202-203.
8. Choi, YW, Hahn, YH. Polymer-coated Liposomes for Oral Drug Delivery. (I). Stability of Polysaccharide-coated Liposomes Against Bile Salts. Yakche Hakhoechi. 1992;22:211-217.
9. Kawaguchi, Y, Matsukawa, K, Gama, Y, Ishigami, Y. The Effects of Polysaccharide Chain Length in Coating Liposomes with Partial Palmitoyl Hyaluronates. Carbohydrate Polymers. 1992;18:139-142.
10. Sehgal, S, Rogers, JA. Formulation Factors in the Development of Polymer-coated Liposomes. Kinetics of Release of Cytarabine (Ara-C)., Pharmaceutical Research. 1992;9:S-229.
11. Elferink, MGL, de Wit, JG, Veld, GI, Reichert, A, Driessen, AJM, Ringsdorf, H, Konings, H. The Stability and Functional Properties of Proteoliposomes Mixed with Dextran Derivatives Bearing Hydrophobic Anchor Groups. Biochim Biophys Acta. 1992;1106:23-30.
12. Berger, Sauvage, LR, Rao, AM. Healing of Arterial Prostheses in Man: Its Incompleteness. Ann Surg. 1972:175:118-127.
13. Stanley, JC. Biologic and Synthetic Vascular Prostheses. New York, NY: Grune & Stratton, Inc.; 1992.
14. Suzuki, M, Mikami, T, Matsumoto, T, Suzuki, S. Preparation and Antitumor Activity of O-Palmitoyldextran Phosphates, O-Palmitoyldextrans, and Dextran Phosphate. Carbohydrate Research, 53, 223-229 (1977).
15. Snyder, F, Stephens, N. A Simplified Spectrophotometric Determination of Ester Groups in Lipids. Biochim Biophys Acta. 1959;34: 244-245 (1959).
16. Tuong, A, Maftouh, M, Picard, C, Gachon, M. Site Specific Radioiodination of Recombinant Hirudin. Analytical Biochem. 1990;189: 186-191.
17. Perrett, S, Golding, M, Williams, WP. A Simple Method for the Preparation of Liposomes for Pharmaceutical Applications: Characterization of the Liposomes. J Pharm Pharmacol. 1991;43: 154-161.
18. Spannagl, M, Bichler, H, Lill, H, Schoursamm, W. A Fast Photometric Assay for the Determination of Hirudin. Haemostasis. 1991; 21: 36-40.
19. Yokoyama, M, Sugiyama, T, Okano, T, Sakurai, Y, Naito, M, Kataoka, K. Analysis of Micelle Formation of an Adriamycin-Conjugated Poly(Ethyleneglycol)-Poly(Aspartic Acid) Block Copolymer by Gel Permeation Chromatography. Pharmaceutical Research. 1993;10: 895-898.
20. Staples, M. Phosphate-Accelerated Decomposition of a Thrombin-Inhibitor Peptide, Hirulog-1. (abstract) Pharmaceutical Research. 1992;9: 79.