Liposome-based formulations for the antibiotic nonapeptide Leucinostatin A: Fourier transform infrared spectroscopy characterization and in vivo toxicologic study

AAPS PharmSciTech

Volumn 1, Issue 1, 2000, Pages

  Ricci, Maurizio ^a   Sassi, Paola ^a   Nastruzzi, Claudio ^a   Rossi, Carlo ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Fourier transform infrared spectroscopy; LD50; Leucinostatin A; Liposomes; Preformulation; Thermotropic phase transition

Indexed keywords

LEUCINOSTATIN A; LIPOSOME; NONAPEPTIDE; POLYPEPTIDE ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; PEPTIDE;

ACREMONIUM; ANIMAL EXPERIMENT; ANTIFUNGAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DEATH; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG ISOLATION; DRUG STABILITY; DRUG STRUCTURE; GRAM POSITIVE BACTERIUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; INFRARED SPECTROSCOPY; LD 50; MALE; MOUSE; NONHUMAN; PAECILOMYCES; PAECILOMYCES LILACINUS; TOXICOLOGY; ANIMAL; CHEMISTRY; METHODOLOGY; MOUSE STRAIN; PHYSICAL CHEMISTRY; THERMODYNAMICS; TOXICITY TESTING;

ACUTE TOXICITY TESTS; ANIMALS; ANTI-INFECTIVE AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CHEMISTRY, PHYSICAL; LETHAL DOSE 50; LIPOSOMES; MICE; MICE, INBRED STRAINS; PEPTIDES; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; THERMODYNAMICS;

EID: 23144444819     PISSN: 15309932     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt010102     Document Type: Article

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