Effect of drug substance particle size on the characteristics of granulation manufactured in a high-shear mixer

AAPS PharmSciTech

Volumn 1, Issue 4, 2000, Pages 7-

  Farag Badawy, Sherif I ^a   Lee, Tara J ^a   Menning, Mark M ^a  

^a DUPONT COMPANY   (United States)

Author keywords

Compressibility; Granulation; Particle size; Porosity

Indexed keywords

4 CYCLOPROPYLETHYNYL 5,6 DIFLUORO 3,4 DIHYDRO 4 TRIFLUOROMETHYL 2(1H) QUINAZOLINONE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; QUINOLONE DERIVATIVE; WATER;

ARTICLE; COMPRESSIVE STRENGTH; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG GRANULATION; DRUG MANUFACTURE; DRUG SOLUBILITY; GEOMETRY; PARTICLE SIZE; PHYSICAL CHEMISTRY; POROSITY; SHEAR STRENGTH; CHEMISTRY; INSTRUMENTATION; MECHANICAL STRESS; METABOLISM; METHODOLOGY; SOLUBILITY; TABLET; WETTABILITY;

CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; PARTICLE SIZE; POROSITY; QUINOLONES; SOLUBILITY; STRESS, MECHANICAL; TABLETS; WATER; WETTABILITY;

EID: 23144437558     PISSN: 15309932     EISSN: 15309932     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Corbett JW, Ko SS, Erikson-Viitanen S et al. Discovery of HIV-1 non-nucleoside reverse transcriptase development candidates DMP 961 and DMP 963. AIDS. 1998;12(supp. 4):P21.
2. Kristensen HG. Agglomeration of powders. Acta Pharm Suec. 1988;25:187-204.
3. Holm P, Schaefer T, Kristensen HG. Granulation in high-speed mixers. Part V. Power consumption and temperature changes during granulation. Powder Technol. 1985;43:213-223.
4. Kristensen HG, Holm P, Schaefer T. Mechanical properties of moist agglomerates in relation to granulation mechanisms. Part I. Deformability of moist, desnsified agglomerates. Powder Technol. 1985;44:227-237.
5. Kristensen HG, Holm P, Schaefer T. Mechanical properties of moist agglomerates in relation to granulation mechanisms. Part II. Effect of particle size distribution. Powder Technol. 1985;44:239-247.
6. Ouchiyama N, Tanaka T. The probability of coalescence in granulation kinetics. Ind. Eng. Chem. Process Des. Dev. 1975;14:286-289.
7. Wikberg M, Alderborn G. Compression characteristics of granulated materials. VI. Pore size distributions, assessed by mercury penetration, of compacts of two lactose granulations with different fragmentation propensities. Pharm Res. 1992;84:191-195.