Evaluation preseparator performance for the 8-stage nonviable Andersen impactor

AAPS PharmSciTech

Volumn 2, Issue 1, 2001, Pages

  Sethuraman, Vasu V ^a   Hickey, Anthony J ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Finite element analysis; Inertial impaction; Preseparator; Wall losses

Indexed keywords

FLUORESCEIN SODIUM; FLUORESCEIN;

AEROSOL; AIRFLOW; ARTICLE; CONTROLLED STUDY; DEVICE; DRY POWDER; FINITE ELEMENT ANALYSIS; FLOW RATE; GEOMETRY; LASER DIFFRACTION; MATHEMATICAL COMPUTING; PARTICLE SIZE; SEPARATION TECHNIQUE; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; CHEMISTRY; COMPARATIVE STUDY; COMPUTER SIMULATION; EQUIPMENT DESIGN; EVALUATION; NEBULIZER; REPRODUCIBILITY; STANDARD;

AEROSOLS; COMPUTER SIMULATION; EQUIPMENT DESIGN; FLUORESCEIN; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE; REPRODUCIBILITY OF RESULTS;

EID: 23144435191     PISSN: 15309932     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt020104     Document Type: Article

References (13)

1. May KR. The cascade impactor: an instrument for sampling coarse aerosols. J Sci Instr. 1945;22:187-195.
2. Vaughan NP. The andersen impactor: calibration, wall losses and numerical simulation. J Aer Sci. 1989;20(1):67-90.
3. Swanson PD, Kushleika J, Checkoway H, et al. Numerical analysis of motion and deposition of particles in cascade impactors. Int J Pharm. 1996;142:33-51.
4. Marple VA. A fundamental study of inertial impactors [dissertation]. University of Minnesota, 1970.
5. Operating manual for Andersen 2000 ambient particle sizing sampler. Atlanta, Ga: Andersen 2000 Inc.; 1977.
6. US Pharmacopoeia. USP 24 Aerosols, Metered-Dose Inhalers, and Dry Powder Inhalers. Rockville, MD: USP; 1999.
7. British Pharmacopoeia. Preparations for Inhalation. Vol. II. London, England: The Stationary Office; 1999.
8. Rader DJ, Marple VA. Effect of ultra-stokesian drag and particle interception on impaction characteristics. Aer Sci Tech. 1984;4:141-156.
9. Welty JR, Wicks CE, Wilson RE. Fundamentals of Momentum, Heat, and Mass Transfer. 3rd ed. New York: John Wiley & Sons; 1984:732-733.
10. Greenspan B. A response to the stimuli to the revision process article: verification of operating the andersen cascade impactor at different flow rates. Pharm Forum. 1996;22(6):3288-3292.
11. Hickey AJ, Jackson GV, Fildes FJT. Preparation and characterization of disodium fluorescein powders in association with lauric and capric acids. J Pharm Sci. 1988;77(9):804-809.
12. American Pharmaceutical Association. Handbook of Pharmaceutical Excipients. Washington, DC: American Pharmaceutical Association; 1986.
13. Thiel CG. Can in vitro particle size measurements be used to predict pulmonary deposition of aerosol from inhalers? J Aer Med. 1998;9(Suppl. 1):S43-S52.