Optimization of the operating conditions of a lab scale Aljet mill using lactose and sucrose: A technical note

AAPS PharmSciTech

Volumn 4, Issue 2, 2003, Pages

  Vatsaraj, Neha B ^a   Gao, Danchen ^a   Kowalski, Donna L ^b  

^a Pharmacia Pharmaceutical and Analytical Sciences   (United States)

^b Department of Nonclinical Statistics ^*  (United States)

Author keywords

Aljet mill; Design of experiments; Micronization; Operating conditions; Optimization

Indexed keywords

DRUG; LACTOSE; SUCROSE;

ARTICLE; CHEMICAL PROCEDURES; DIFFRACTION; DRUG MANUFACTURE; EQUIPMENT DESIGN; EXPERIMENTAL DESIGN; LABORATORY; PARTICLE SIZE; PROCESS OPTIMIZATION; CHEMISTRY; PHARMACEUTICS;

CHEMISTRY, PHARMACEUTICAL; LACTOSE; SUCROSE; TECHNOLOGY, PHARMACEUTICAL;

EID: 23144434204     PISSN: 15309932     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt040227     Document Type: Article

References (12)

1. Heng P, Wong T, Shu J, Wan L. A new method for the control of size of pellets in the melt pelletization process with a high shear mixer. Chem Pharm Bull. 1999; 47(5):633-638.
2. Swarbrick J, Boylan J, eds. Encyclopedia of Pharmaceutical Technology: Unit Processes in Pharmacy: the Operations. Vol 16. New York, NY: Marcel Dekker; 1997:1-114.
3. Geze A, Venier-Julienne M, Mathieu D, Filmon R, Phan-Tan-Luu R, Benoit J. Development of 5-iodo-2′-deoxyuridine milling process to reduce initial burst release from PLGA microparticles. Int J Pharm. 1999; 178:257-268.
4. Vidgren P, Vidgren M, Paronen P. Physical stability and inhalation behaviour of mechanically micronized and spray-dried disodium cromoglycate in different humidities. Acta Pharm Fenn. 1989; 98:71-78.
5. Rasenack N, Muller B. Dissolution rate enhancement by in situ micronization of poorly water-soluble drugs. Pharm Res. 2002; 19(12):1894-1900.
6. Kawashima Y. Nanoparticulate systems for improved drug delivery. Adv Drug Deliv Rev. 2001; 47:1-2.
7. Fincher J. Particle size of drugs and its relationship to absorption and activity. J Pharm Sci. 1968;57(11):1825-1835.
8. Parrott E. Milling of pharmaceutical solids. J Pharm Sci. 1974;63(6):813-829.
9. Dobson B, Rothwell E. Particle size reduction in a fluid energy mill. Powder Technol. 1969-70; 3:213-217.
10. Nykamp G, Cartensen U, Muller B. Jet milling-a new technique for microparticle preparation. Int J Pharm. 2002; 242:79-86.
11. Akbarieh M, Tawashi R. Morphic features of solid particles after micronization in the fluid energy mill. Int J Pharm. 1987; 35:81-89.
12. Mehta K, Kislalioglu S, Phuapradit W, Malick W, Shah N. Multi-unit controlled release systems of Nifedipine and Nifedipine: Pluronice F-68 solid dispersions: characterization of release mechanisms. Drug Dev Ind Pharm. 2002; 28(3): 275-285.