CD20-positive infiltrates in human membranous glomerulonephritis

Journal of Nephrology

Volumn 18, Issue 3, 2005, Pages 328-333

  Cohen, Clemens D ^a   Calvaresi, Novella ^b   Armelloni, Silvia ^b   Schmid, Holger ^a   Henger, Anna ^a   Ott, Undine ^c   Rastaldi, Maria P ^b   Kretzler, Matthias ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b SAN CARLO BORROMEO HOSPITAL   (Italy)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Gene expression; Molecular diagnosis; Podocytes; Proteinuria; Tubulo interstitium

Indexed keywords

CD20 ANTIGEN; MESSENGER RNA;

ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; B LYMPHOCYTE; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; FOCAL GLOMERULOSCLEROSIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATORY INFILTRATE; KIDNEY BIOPSY; MEMBRANOUS GLOMERULONEPHRITIS; NEPHRECTOMY; PATHOGENESIS; REAL TIME POLYMERASE CHAIN REACTION;

ANTIGENS, CD20; B-LYMPHOCYTES; BIOPSY; EXTRACELLULAR FLUID; GLOMERULONEPHRITIS, MEMBRANOUS; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE COUNT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA;

EID: 23144432444     PISSN: 11218428     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (26)

1. Glassock, RJ. Diagnosis and natural course of membranous nephropathy. Semin Nephrol 2003; 23: 324-32.
2. Hogan SL, Muller KE, Jennette JC, Falk RJ. A review of therapeutic studies of idiopathic membranous glomerulopathy. Am J Kidney Dis 1995; 25: 862-75.
3. Kerjaschki D, Farquhar MG. Immunocytochemical localization of the Heymann nephritis antigen (GP330) in glomerular epithelial cells of normal Lewis rats. J Exp Med 1983; 157: 667-86.
4. Farquhar MG, Saito A, Kerjaschki D, Orlando RA. The Heymann nephritis antigenic complex: megalin (gp330) and RAP. J Am Soc Nephrol 1995; 6: 35-47.
5. Debiec H, Guigonis V, Mougenot B, Decobert F, Haymann JP, Bensman A, Deschenes G, Ronco PM. Antenatal membranous glomerulonephritis due to anti-neutral endopeptidase antibodies. N Engl J Med 2002; 346: 2053-60.
6. Debiec H, Nauta J, Coulet F, van der Burg M, Guigonis V, Schurmans T, de Heer E, Soubrier F, Janssen F, Ronco P. Role of truncating mutations in MME gene in fetomaternal alloimmunisation and antenatal glomerulopathies. Lancet 2004; 364: 1252-9.
7. Biancone L, Andres G, Ahn H, DeMartino C, Stamenkovic I. Inhibition of the CD40-CD40ligand pathway prevents murine membranous glomerulonephritis. Kidney Int 1995; 48: 458-68.
8. Penny MJ, Boyd RA, Hall BM. Mycophenolate mofetil prevents the induction of active Heymann nephritis: association with Th2 cytokine inhibition. J Am Soc Nephrol 1998; 9: 2272-82.
9. Remuzzi G, Chiurchiu C, Abbate M, Brusegan V, Bontempelli M, Ruggenenti P. Rituximab for idiopathic membranous nephropathy. Lancet 2002; 360: 923-4.
10. Ruggenenti P, Chiurchiu C, Brusegan V, Abbate M, Perna A, Filippi C, Remuzzi G. Rituximab in idiopathic membranous nephropathy: a one-year prospective study. J Am Soc Nephrol 2003; 14: 1851-7.
11. Ronco P, Allegri L, Brianti E, Chatelet F, Van Leer EH, Verroust P. Antigenic targets in epimembranous glomerulonephritis. Experimental data and potential application in human pathology. Appl Pathol 1989; 7: 85-98.
12. Assmann KJ, van Son JP, Dijkman HB, Koene RA. A nephritogenic rat monoclonal antibody to mouse aminopeptidase A. Induction of massive albuminuria after a single intravenous injection. J Exp Med 1992; 175: 623-35.
13. Sugisaki T, Klassen J, Andres GA, Milgrom F, McCluskey RT. Passive transfer of Heymann nephritis with serum. Kidney Int 1973; 3: 66-73.
14. Assmann KJ, Tangelder MM, Lange WP, Tadema TM, Koene RA. Membranous glomerulonephritis in the mouse. Kidney Int 1983; 24: 303-12.
15. Cohen CD, Frach K, Schlondorff D, Kretzler M. Quantitative gene expression analysis in renal biopsies: a novel protocol for a high-throughput multicenter application. Kidney Int 2002; 61: 133-40.
16. Edwards JC, Szczepanski L, Szechinski J, Filipowicz-Sosnowska A, Emery P, Close DR, Stevens RM, Shaw T. Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med 2004; 350: 2572-81.
17. Leandro MJ, Edwards JC, Cambridge G, Ehrenstein MR, Isenberg DA. An open study of B lymphocyte depletion in systemic lupus erythematosus. Arthritis Rheum 2002; 46: 2673-7.
18. Fra GP, Avanzi GC, Bartoli E. Remission of refractory lupus nephritis with a protocol including rituximab. Lupus 2003; 12: 783-7.
19. Zaja F, De Vita S, Mazzaro C, Sacco S, Damiani D, De Marchi G, Michelutti A, Baccarani M, Fanin R, Ferraccioli G. Efficacy and safety of rituximab in type II mixed cryoglobulinemia. Blood 2003; 101: 3827-34.
20. Roccatello D, Baldovino S, Rossi D, Mansouri M, Naretto C, Gennaro M, Cavallo R, Alpa M, Costanzo P, Giachino O, Mazzucco G, Sena LM. Long-term effects of anti-CD20 monoclonal antibody treatment of cryoglobulinaemic glomerulonephritis. Nephrol Dial Transplant 2004; 19: 3054-61.
21. Keogh KA, Wylam ME, Stone JH, Specks U. Induction of remission by B lymphocyte depletion in eleven patients with refractory antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum 2005; 52: 262-8.
22. Kazkaz H, Isenberg D. Anti B cell therapy (rituximab) in the treatment of autoimmune diseases. Curr Opin Pharmacol 2004; 4: 398-402.
23. Silverman GJ, Weisman S. Rituximab therapy and autoimmune disorders: prospects for anti-B cell therapy. Arthritis Rheum 2003; 48: 1484-92.
24. Sarwal M, Chua MS, Kambham N, Hsieh SC, Satterwhite T, Masek M, Salvatierra O, Jr. Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. N Engl J Med 2003; 349: 125-38.
25. Kerjaschki D, Regele HM, Moosberger I, Nagy-Bojarski K, Watschinger B, Soleiman A, Birner P, Krieger S, Hovorka A, Silberhumer G, Laakkonen P, Petrova T, Langer B, Raab I. Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates. J Am Soc Nephrol 2004; 15: 603-12.
26. Burne-Taney MJ, Ascon DB, Daniels F, Racusen L, Baldwin W, Rabb H. B cell deficiency confers protection from renal ischemia reperfusion injury. J Immunol 2003; 171: 3210-5.