Insect chemoreception

Current Opinion in Neurobiology

Volumn 15, Issue 4, 2005, Pages 423-430

  Dahanukar, Anupama ^a   Hallem, Elissa A ^a   Carlson, John R ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; MEMBRANE RECEPTOR; PHEROMONE; PHEROMONE RECEPTOR;

CHEMORECEPTOR; DENDRITE; DIMERIZATION; DROSOPHILA; GUSTATORY SYSTEM; INSECT; MOSQUITO; MOTH; NERVE CELL; NONHUMAN; ODOR; OLFACTORY RECEPTOR; OLFACTORY SYSTEM; ORDO; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVIEW; SENSORY NERVE CELL; TASTE; TASTE BUD;

ANIMALS; CHEMORECEPTORS; HUMANS; RECEPTORS, ODORANT; SMELL; TASTE;

EID: 23044512619     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.conb.2005.06.001     Document Type: Review

References (66)

1. R.F. Stocker The organization of the chemosensory system in Drosophila melanogaster: a review Cell Tissue Res 275 1994 3 26
2. V. Rodrigues, and O. Siddiqi Genetic-analysis of chemosensory pathway Proc Indian Acad Sci [B] 87 1978 147 160
3. P.J. Clyne, C.G. Warr, M.R. Freeman, D. Lessing, J. Kim, and J.R. Carlson A novel family of divergent seven-transmembrane proteins: candidate odorant receptors in Drosophila Neuron 22 1999 327 338
4. P.J. Clyne, C.G. Warr, and J.R. Carlson Candidate taste receptors in Drosophila Science 287 2000 1830 1834
5. L.B. Vosshall, H. Amrein, P.S. Morozov, A. Rzhetsky, and R. Axel A spatial map of olfactory receptor expression in the Drosophila antenna Cell 96 1999 725 736
6. H.M. Robertson, C.G. Warr, and J.R. Carlson Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster Proc Natl Acad Sci USA 100 2003 14537 14542
7. A.N. Fox, R.J. Pitts, H.M. Robertson, J.R. Carlson, and L.J. Zwiebel Candidate odorant receptors from the malaria vector mosquito Anopheles gambiae and evidence of down-regulation in response to blood feeding Proc Natl Acad Sci USA 98 2001 14693 14697
8. C.A. Hill, A.N. Fox, R.J. Pitts, L.B. Kent, P.L. Tan, M.A. Chrystal, A. Cravchik, F.H. Collins, H.M. Robertson, and L.J. Zwiebel G protein-coupled receptors in Anopheles gambiae Science 298 2002 176 178
9. J. Krieger, K. Raming, Y.M. Dewer, S. Bette, S. Conzelmann, and H. Breer A divergent gene family encoding candidate olfactory receptors of the moth Heliothis virescens Eur J Neurosci 16 2002 619 628
10. T. Sakurai, T. Nakagawa, H. Mitsuno, H. Mori, Y. Endo, S. Tanoue, Y. Yasukochi, K. Touhara, and T. Nishioka Identification and functional characterization of a sex pheromone receptor in the silkmoth Bombyx mori Proc Natl Acad Sci USA 101 2004 16653 16658
11. L.B. Vosshall, A.M. Wong, and R. Axel An olfactory sensory map in the fly brain Cell 102 2000 147 159
12. A.A. Dobritsa, W. van der Goes van Naters, C.G. Warr, R.A. Steinbrecht, and J.R. Carlson Integrating the molecular and cellular basis of odor coding in the Drosophila antenna Neuron 37 2003 827 841
13. A.L. Goldman, W. Van der Goes van Naters, D. Lessing, C.G. Warr, and J.R. Carlson Coexpression of two functional odor receptors in one neuron Neuron 45 2005 661 666 The authors find that two functional odorant receptors are coexpressed in an ORN of the maxillary palp. The coexpression of odorant receptors in a single ORN could expand the coding capacity of the olfactory system. This study also establishes a receptor-to-neuron map for the Drosophila maxillary palp.
14. S.A. Kreher, J.Y. Kwon, and J.R. Carlson The molecular basis of odor coding in the Drosophila larva Neuron 46 2005 445 456 The authors identify a subset of Or genes that are expressed in Drosophila larvae. Some Or genes are larval-specific, whereas others are also expressed in the adult. The larval-specific receptors were functionally characterized using an empty neuron as a 'decoder'. Projections of the ORNs that express these receptors were mapped to specific glomeruli in the larval antennal lobe.
15. T. Elmore, and D.P. Smith Putative Drosophila odor receptor OR43b localizes to dendrites of olfactory neurons Insect Biochem Mol Biol 31 2001 791 798
16. T. Elmore, R. Ignell, J.R. Carlson, and D.P. Smith Targeted mutation of a Drosophila odor receptor defines receptor requirement in a novel class of sensillum J Neurosci 23 2003 9906 9912
17. E.A. Hallem, M.G. Ho, and J.R. Carlson The molecular basis of odor coding in the Drosophila antenna Cell 117 2004 965 979 The authors perform a large-scale functional analysis of the antennal odorant receptor repertoire, using an empty neuron as a 'decoder'. The odor response spectra of most receptors are identified, and a receptor-to-neuron map is established for the Drosophila antenna. In addition, the odorant receptor is found to determine not only the odor response spectrum of the ORN but also many of its other response properties.
18. Q. Gao, B. Yuan, and A. Chess Convergent projections of Drosophila olfactory neurons to specific glomeruli in the antennal lobe Nat Neurosci 3 2000 780 785
19. P. Mombaerts Genes and ligands for odorant, vomeronasal and taste receptors Nat Rev Neurosci 5 2004 263 278
20. R.F. Stocker, M.C. Lienhard, A. Borst, and K.F. Fischbach Neuronal architecture of the antennal lobe in Drosophila melanogaster Cell Tissue Res 262 1990 9 34
21. J.W. Wang, A.M. Wong, J. Flores, L.B. Vosshall, and R. Axel Two-photon calcium imaging reveals an odor-evoked map of activity in the fly brain Cell 112 2003 271 282
22. M. Ng, R.D. Roorda, S.Q. Lima, B.V. Zemelman, P. Morcillo, and G. Miesenbock Transmission of olfactory information between three populations of neurons in the antennal lobe of the fly Neuron 36 2002 463 474
23. A. Fiala, T. Spall, S. Diegelmann, B. Eisermann, S. Sachse, J.M. Devaud, E. Buchner, and C.G. Galizia Genetically expressed cameleon in Drosophila melanogaster is used to visualize olfactory information in projection neurons Curr Biol 12 2002 1877 1884
24. C.G. Galizia, S. Sachse, A. Rappert, and R. Menzel The glomerular code for odor representation is species specific in the honeybee Apis mellifera Nat Neurosci 2 1999 473 478
25. J. Meijerink, M.A. Carlsson, and B.S. Hansson Spatial representation of odorant structure in the moth antennal lobe: a study of structure-response relationships at low doses J Comp Neurol 467 2003 11 21
26. H.T. Skiri, C.G. Galizia, and H. Mustaparta Representation of primary plant odorants in the antennal lobe of the moth Heliothis virescens using calcium imaging Chem Senses 29 2004 253 267
27. R.I. Wilson, G.C. Turner, and G. Laurent Transformation of olfactory representations in the Drosophila antennal lobe Science 303 2004 366 370
28. D. Yu, A. Ponomarev, and R.L. Davis Altered representation of the spatial code for odors after olfactory classical conditioning; memory trace formation by synaptic recruitment Neuron 42 2004 437 449
29. T. Faber, J. Joerges, and R. Menzel Associative learning modifies neural representations of odors in the insect brain Nat Neurosci 2 1999 74 78
30. E.O. Aceves-Pina, and W.G. Quinn Learning in normal and mutant Drosophila larvae Science 206 1979 93 95
31. P. Monte, C. Woodard, R. Ayer, M. Lilly, H. Sun, and J. Carlson Characterization of the larval olfactory response in Drosophila and its genetic basis Behav Genet 19 1989 267 283
32. R.N. Singh, and K. Singh Fine structure of the sensory organs of Drosophila melanogaster meigen larva (Diptera: Drosophilidae) Int J Insect Morphol Embryol 13 1984 255 273
33. F. Python, and R.F. Stocker Adult-like complexity of the larval antennal lobe of D. melanogaster despite markedly low numbers of odorant receptor neurons J Comp Neurol 445 2002 374 387
34. M.C. Larsson, A.I. Domingos, W.D. Jones, M.E. Chiappe, H. Amrein, and L.B. Vosshall Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction Neuron 43 2004 703 714 The authors analyze a deletion mutant to reveal that the non-canonical odorant receptor Or83b is essential for efficient expression of other odorant receptors in ORN dendrites. In the absence of Or83b, electrophysiological and behavioral responses to odorants are severely compromised.
35. K. Scott, R. Brady Jr., A. Cravchik, P. Morozov, A. Rzhetsky, C. Zuker, and R. Axel A chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila Cell 104 2001 661 673
36. L. Dunipace, S. Meister, C. McNealy, and H. Amrein Spatially restricted expression of candidate taste receptors in the Drosophila gustatory system Curr Biol 11 2001 822 835
37. S. Chyb, A. Dahanukar, A. Wickens, and J.R. Carlson Drosophila Gr5a encodes a taste receptor tuned to trehalose Proc Natl Acad Sci USA 100 2003 14526 14530
38. Z. Wang, A. Singhvi, P. Kong, and K. Scott Taste representations in the Drosophila brain Cell 117 2004 981 991 This study describes the mapping of several taste receptor genes in Drosophila gustatory neurons and their projections to the brain using reporter gene expression. The authors also examine co-expression of receptor genes and behavioral consequences of silencing subsets of sensory neurons. They present a simple model for gustatory coding in flies, suggesting that sensory neurons are segregated into classes of 'acceptance' or 'avoidance' neurons.
39. ••].
40. S. Bray, and H. Amrein A putative Drosophila pheromone receptor expressed in male-specific taste neurons is required for efficient courtship Neuron 39 2003 1019 1029
41. M. de Bruyne, K. Foster, and J.R. Carlson Odor coding in the Drosophila antenna Neuron 30 2001 537 552
42. G.S. Suh, A.M. Wong, A.C. Hergarden, J.W. Wang, A.F. Simon, S. Benzer, R. Axel, and D.J. Anderson A single population of olfactory sensory neurons mediates an innate avoidance behaviour in Drosophila Nature 431 2004 854 859
43. K.F. Stortkuhl, and R. Kettler Functional analysis of an olfactory receptor in Drosophila melanogaster Proc Natl Acad Sci USA 98 2001 9381 9385
44. C.H. Wetzel, H.J. Behrendt, G. Gisselmann, K.F. Stortkuhl, B. Hovemann, and H. Hatt Functional expression and characterization of a Drosophila odorant receptor in a heterologous cell system Proc Natl Acad Sci USA 98 2001 9377 9380
45. E.A. Hallem, A. Nicole Fox, L.J. Zwiebel, and J.R. Carlson Olfaction: mosquito receptor for human-sweat odorant Nature 427 2004 212 213 The function of two mosquito odorant receptors was tested in an in vivo Drosophila expression system. One receptor responds to a component of human sweat.
46. W. Takken, J.J. van Loon, and W. Adam Inhibition of host-seeking response and olfactory responsiveness in Anopheles gambiae following blood feeding J Insect Physiol 47 2001 303 310
47. M. de Bruyne, P.J. Clyne, and J.R. Carlson Odor coding in a model olfactory organ: the Drosophila maxillary palp J Neurosci 19 1999 4520 4532
48. A.C. Melo, M. Rutzler, R.J. Pitts, and L.J. Zwiebel Identification of a chemosensory receptor from the yellow fever mosquito, Aedes aegypti, that is highly conserved and expressed in olfactory and gustatory organs Chem Senses 29 2004 403 410
49. W.D. Jones, T.A. Nguyen, B. Kloss, K.J. Lee, and L.B. Vosshall Functional conservation of an insect odorant receptor gene across 250 million years of evolution Curr Biol 15 2005 R119 R121 This study shows that function of the non-canonical receptor, Or83b, is conserved across insect orders. Or83b orthologs from other Diptera, or Lepidoptera, can rescue Or83b function in mutant Drosophila.
50. T. Nakagawa, T. Sakurai, T. Nishioka, and K. Touhara Insect sex-pheromone signals mediated by specific combinations of olfactory receptors Science 307 2005 1638 1642 The authors functionally express two moth pheromone receptors in Xenopus oocytes. Both require the presence of the moth Or83b ortholog for enrichment at the membrane. They demonstrate that the two pheromone receptors are expressed in neighboring neurons and that the moth Or83b ortholog is also expressed in these neurons.
51. J. Krieger, O. Klink, C. Mohl, K. Raming, and H. Breer A candidate olfactory receptor subtype highly conserved across different insect orders J Comp Physiol A Neuroethol Sens Neural Behav Physiol 189 2003 519 526
52. R.J. Pitts, A.N. Fox, and L.J. Zwiebel A highly conserved candidate chemoreceptor expressed in both olfactory and gustatory tissues in the malaria vector Anopheles gambiae Proc Natl Acad Sci USA 101 2004 5058 5063
53. E.M. Neuhaus, G. Gisselmann, W. Zhang, R. Dooley, K. Stortkuhl, and H. Hatt Odorant receptor heterodimerization in the olfactory system of Drosophila melanogaster Nat Neurosci 8 2005 15 17 The authors find that reduction in Or83b protein levels using RNAi results in decreased electrophysiological responses to odorants. BRET analysis of odorant receptors in HEK293 cells reveals that Or83b can form heterodimers with other receptors, thus providing insight into the mechanism of Or83b function. Other odorant receptors were also capable of homodimerization.
54. A. Dahanukar, K. Foster, W.M. van der Goes van Naters, and J.R. Carlson A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila Nat Neurosci 4 2001 1182 1186
55. K. Ueno, M. Ohta, H. Morita, Y. Mikuni, S. Nakajima, K. Yamamoto, and K. Isono Trehalose sensitivity in Drosophila correlates with mutations in and expression of the gustatory receptor gene Gr5a Curr Biol 11 2001 1451 1455
56. N. Inomata, H. Goto, M. Itoh, and K. Isono A single-amino-acid change of the gustatory receptor gene, Gr5a, has a major effect on trehalose sensitivity in a natural population of Drosophila melanogaster Genetics 167 2004 1749 1758
57. V.G. Dethier The Hungry Fly 1976 Harvard University Press Cambridge
58. J.I. Glendinning, A. Davis, and S. Ramaswamy Contribution of different taste cells and signaling pathways to the discrimination of "bitter" taste stimuli by an insect J Neurosci 22 2002 7281 7287
59. M. Hiroi, F. Marion-Poll, and T. Tanimura Differentiated response to sugars among labellar chemosensilla in Drosophila Zoolog Sci 19 2002 1009 1018
60. M. Hiroi, N. Meunier, F. Marion-Poll, and T. Tanimura Two antagonistic gustatory receptor neurons responding to sweet-salty and bitter taste in Drosophila J Neurobiol 61 2004 333 342
61. N. Meunier, F. Marion-Poll, J.P. Rospars, and T. Tanimura Peripheral coding of bitter taste in Drosophila J Neurobiol 56 2003 139 152
62. K. Scott The sweet and bitter of mammalian taste Curr Opin Neurobiol 14 2004 423 427
63. W.S. Leal Pheromone reception Top Curr Chem 240 2004 1 36
64. D.S. Hekmat-Scafe, C.R. Scafe, A.J. McKinney, and M.A. Tanouye Genome-wide analysis of the odorant-binding protein gene family in Drosophila melanogaster Genome Res 12 2002 1357 1369
65. M.S. Kim, A. Repp, and D.P. Smith LUSH odorant-binding protein mediates chemosensory responses to alcohols in Drosophila melanogaster Genetics 150 1998 711 721
66. P. Xu, R. Atkinson, D.N. Jones, and D.P. Smith Drosophila OBP LUSH is required for activity of pheromone-sensitive neurons Neuron 45 2005 193 200 This study reports the first genetic evidence for the role of an OBP in pheromone reception.