Pediatric fatality following ingestion of dinitrophenol: Postmortem identification of a "dietary supplement"

Clinical Toxicology

Volumn 43, Issue 4, 2005, Pages 281-285

  Hsiao, Allen L ^a,b   Santucci, Karen A ^a   Seo Mayer, Patricia ^a   Mariappan, M Rajan ^a   Hodsdon, Michael E ^a   Banasiak, Kenneth J ^a   Baum, Carl R ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

Dietary supplement; Dinitrophenol; DNP; Fatality; Pediatric

Indexed keywords

2,4 DINITROPHENOL;

ADOLESCENT; ANAMNESIS; ARTICLE; AUTOPSY; BLOOD ANALYSIS; CASE REPORT; CLINICAL EXAMINATION; DIET SUPPLEMENTATION; DRUG BLOOD LEVEL; DRUG FATALITY; DRUG OVERDOSE; FATALITY; FEMALE; HUMAN; LABORATORY TEST; PHYSICAL EXAMINATION; SUICIDE ATTEMPT; WEIGHT REDUCTION;

ADOLESCENT; ANTI-OBESITY AGENTS; DIETARY SUPPLEMENTS; DINITROPHENOLS; EMERGENCY MEDICAL SERVICES; FATAL OUTCOME; FEMALE; FUNGICIDES, INDUSTRIAL; HEPATITIS, TOXIC; HUMANS; PULMONARY EDEMA; SUICIDE; UNCOUPLING AGENTS;

EID: 23044509078     PISSN: 07313810     EISSN: None     Source Type: Journal    
DOI: 10.1081/CLT-200058946     Document Type: Article

References (25)

1. McFee RB, Caraccio T, McGuigan M, Reynolds S, Bellander P. Dying to be thin: a dinitrophenol related fatality. Vet Hum Toxicol 2004; 46(5):251-254.
2. Pace S, Pace A. Dinitrophenol oral ingestion resulting in death [abstract]. J Toxicol, Clin Toxicol 2002; 40(5):683.
3. Leftwich R, Floro J, Neal R, Wood A. Dinitrophenol poisoning: a diagnosis to consider in undiagnosed fever. South Med J 1982; 75(2):182-184.
4. MacNab A, Fielden S. Successful treatment of dinitrophenol poisoning in a child. Pediatr Emerg Care 1998; 14(2):136-138.
5. Cann H, Verhulst H. Fatality from acute dinitrophenol derivative poisoning. Am J Dis Child 1960; 100:947-948.
6. Parascandola J. Dinitrophenol and bioenergetics: an historical perspective. Mol Cell Biochem 1974; 5(1):69-77.
7. Kurt T, Anderson R, Petty C, Bost R, Reed G, Holland J. Dinitrophenol in weight loss: the poison center and public health safety. Vet Hum Toxicol 1986; 28(6):574-575.
8. POISINDEX® System. In: Toll L, Hurlbut K, eds. MICROMEDEX [online reference]. Vol. 118. Greenwood Village, Colorado. Accessed September 12, 2003.
9. Dempsey D. Pentachlorophenol and dinitrophenol. In: Olson K, ed. Poisoning and Drug Overdose. 3rd ed. Stamford, CT: Appleton & Lange, 1999:252-254.
10. Simon HB. Hyperthermia. N Engl J Med 1993; 329:483-487.
11. Klaassen C. Nonmetallic environmental toxicants: air pollutants, solvents, vapors, and pesticides. In: Hardman J, Limbird L, eds. Goodman and Oilman's the Pharmacological Basis of Therapeutics. 9th ed. McGraw-Hill Companies, 1996:1691.
12. Serdula M. Weight control practices in adults: results of a multi-state telephone survey. Am J Public Health 1994; 84(11):1821-1824.
13. Cutting W, Mehrtens H, Tainter M. Actions and uses of dinitrophenol: promising metabolic applications. JAMA 1933; 101(3):193-195.
14. Tainter M, Stockton A, Cutting W. Dinitrophenol in the treatment of obesity: final report. JAMA 1935; 105(5):332-337.
15. Tainter M, Cutting W, Stockton A. Use of dinitrophenol in nutritional disorders: a critical survey of clinical results. Am J Public Health 1936; 24:1045-1053.
16. Horner W, Jones R, Boardman W. Cataracts following the use of dinitrophenol. JAMA 1935; 105(2):108-110.
17. Harper J, Dickinson K, Brand M. Mitochondrial uncoupling as a target for drug development for the treatment of obesity. Obes Rev 2001; 2:255-265.
18. Bulik C. Abuse of drugs associated with eating disorders. J Subst Abuse 1992; 4(1):69-90.
19. Hutchins G. Ma huang toxicity. Mayo Clin Proc 2002; 77(7):733.
20. du Boisgueheneuc F, Lannuzel A, Caparros-Lefebvre D, De Broucker T. Cerebral infarction in a patient consuming ma huang extract and guarana. Presse Med 2001; 30(4):166-167.
21. Kockler D, McCarthy M, Lawson C. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001; 21(5):647-651.
22. Klausner H. Infrequent causes of stroke. Emerg Med Clin North Am 2002; 20(3):657.
23. Cupp M. Herbal remedies: adverse effects and drug interactions. Am Fam Phys 1999; 59(5):1239-1245.
24. Connolly H, Crary J, McGoon M, Hensrud D, Edwards B, Edwards W, Schaff H. Valvular heart disease associated with fenfluramine-phentermine. N Engl J Med 1997; 337:581-588.
25. Kernan W, Viscoli C, Brass L, Broderick J, Brott T, Feldmann E, Morgenstern L, Wilterdink J, Horwitz R. Phenylpropanolamine and the risk of hemorrhagic stroke. N Engl J Med 2000; 343(25):1826-1832.