Structure of the tetrameric form of human L-xylulose reductase: Probing the inhibitor-binding site with molecular modeling and site-directed mutagenesis

Proteins: Structure, Function and Genetics

Volumn 60, Issue 3, 2005, Pages 424-432

  El Kabbani, Ossama ^a   Carbone, Vincenzo ^a   Darmanin, Connie ^a   Ishikura, Syuhei ^b   Hara, Akira ^b  

^a MONASH UNIVERSITY   (Australia)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Molecular modeling; Short chain dehydrogenase reductase; Site directed mutagenesis; X ray crystallography; Xylulose reductase

Indexed keywords

ARGININE; CARBOXYLIC ACID DERIVATIVE; CYSTEINE; GLUTAMIC ACID; GLUTAMINE; GUANIDINE DERIVATIVE; HISTIDINE; MONOMER; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OXIDOREDUCTASE; PHENYLALANINE; TETRAMER; TRYPTOPHAN; UNCLASSIFIED DRUG; XYLULOSE REDUCTASE;

ALPHA HELIX; ARTICLE; BETA SHEET; BINDING SITE; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVE SITE; ENZYME INACTIVATION; HUMAN; HYDROGEN BOND; MOLECULAR INTERACTION; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE; RAT; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; ARGININE; BINDING SITES; CATALYSIS; COMPUTATIONAL BIOLOGY; CYSTEINE; DIMERIZATION; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; LUNG; MICE; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; NADP; OXIDOREDUCTASES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, QUATERNARY; PROTEOMICS; RATS; STEREOISOMERISM; SUGAR ALCOHOL DEHYDROGENASES;

RODENTIA;

EID: 23044502251     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.20487     Document Type: Article

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