Inhibition of melatonin biosynthesis activates protein kinase A and induces Alzheimer-like tau hyperphosphorylation in rats

Chinese Medical Sciences Journal

Volumn 20, Issue 2, 2005, Pages 83-87

  Zhu, Ling Qiang ^a   Wang, Shao Hui ^a   Ling, Zhi Qun ^a   Wang, Qun ^a   Hu, Mao Qiong ^a   Wang, Jian Zhi ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Alzheimer's disease; Haloperidol; Melatonin; Protein kinase A; Tau

Indexed keywords

ACETYLSEROTONIN METHYLTRANSFERASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; EPITOPE; GLYCOGEN SYNTHASE KINASE 3; HALOPERIDOL; MELATONIN; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING;

ANIMALS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; EPITOPES; GLYCOGEN SYNTHASE KINASE 3; HALOPERIDOL; HIPPOCAMPUS; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENTRICULAR; MALE; MELATONIN; PHOSPHORYLATION; RATS; RATS, WISTAR; TAU PROTEINS;

EID: 23044497748     PISSN: 10019294     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Arriagada PV, Growdon JH, Hedley-Whyte ET, et al. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 1992;42:631-9.
2. Grundke-Iqbal I, Iqbal K, Quinlan M, et al. Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem 1986;261:6084-9.
3. Asayama K, Yamadera H, Ito T, et al. Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia. J Nippon Med Sch 2003;70:334-41.
4. Mahlberg R, Kunz D, Sutej I, et al. Melatonin treatment of day-night rhythm disturbances and sundowning in Alzheimer disease: an open-label pilot study using actigraphy. J Clin Psychopharmacol 2004;24:456-9.
5. Zhou JN, Liu RY, Kamphorst W, et al. Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels. J Pineal Res 2003; 35:125-30.
6. Liu SJ, Wang JZ. Alzheimer-like tau phosphorylation induced by wortmannin in vivo and its attenuation by melatonin. Acta Pharmacol Sin 2002;23:183-7.
7. Wang DL, Ling ZQ, Cao FY, et al. Melatonin attenuates isoproterenol-induced PKA overactivation and tau hyperphosphorylation in rat brain. J Pineal Res 2004;37:11-6.
8. Satake N, Morton B. Scotophobin A causes dark avoidance in goldfish by elevating pineal N-acetylserotonin. Pharmacol Biochem Behav 1979;10:449-56.
9. Satake N, Morton B. Pineal hydroxyindole-O-methyltransferase: mechanism, and inhibition by scotophobin A. Pharmacol Biochem Behav 1979;10:457-62.
10. Cremer-Bartels G, Ebels I, Sykes JE, et al. Effects of retinal and pineal low molecular weight fractions and antipsychotic drugs on hydroxyindole-O- methyltransferase. J Neural Transm 1983;58:107-19.
11. Akamine T, Nishimura Y, Ito K, et al. Effects of haloperidol on K (+) currents in acutely isolated rat retinal ganglion cells. Invest Ophthalmol Vis Sci 2002;43:1257-61.
12. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. 4th ed. San Diegor:Academic Press; 1998.
13. Liu SJ, Zhang JY, Li HL, et al. Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain. J Biol Chem 2004;279:50078-88.
14. Bechgaard E, Lindhardt K, Martinsen L. High-performance liquid chromatographic analysis of melatonin in human plasma and rabbit serum with on-line column enrichment. J Chromatogr B Biomed Sci Appl 1998;712:177-81.
15. Pei JJ, Tanaka T, Tung YC, et al. Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain. J Neuropathol Exp Neurol 1997;56:70-8.
16. Tsujio I, Tanaka T, Kudo T, et al. Inactivation of glycogen synthase kinase-3 by protein kinase C delta: implications for regulation of tau phosphorylation. FEBS Lett 2000;469:111-7.
17. Wang JZ, Gong CX, Zaidi T, et al. Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B. J Biol Chem 1995;270:4854-60.
18. Gong CX, Lidsky T, Wegiel J, et al. Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease. J Biol Chem 2000;275:5535-44.
19. Wang JZ, Wu Q, Smith A, et al. Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase. FEBS Lett 1998;436:28-34.
20. Zhu LQ, Wang SH, Ling ZQ, et al. Effect of inhibiting melatonin biosynthesis on spatial memory retention and tau phosphorylation in rat. J Pineal Res 2004;37:71-7.
21. Andorfer CA, Davies P. PKA phosphorylations on tau: developmental studies in the mouse. Dev Neurosci 2000;22:303-9.
22. Mallo C, Zaidan R, Galy G, et al. Pharmacokinetics of melatonin in man after intravenous infusion and bolus injection. Eur J Clin Pharmacol 1990;38:297-301.
23. Uchida K, Okamoto N, Ohara K, et al. Daily rhythm of serum melatonin in patients with dementia of the degenerate type. Brain Res 1996;717:154-9.
24. Picinato MC, Haber EP, Cipolla-Neto J, et al. Melatonin inhibits insulin secretion and decreases PKA levels without interfering with glucose metabolism in rat pancreatic islets. J Pineal Res 2002;33:156-60.
25. Karlsson AM, Lerner MR, Unett D, et al. Melatonin-induced organelle movement in melanophores is coupled to tyrosine phosphorylation of a high molecular weight protein. Cell Signal 2000;12:469-74.
26. Vanecek J, Klein DC. Sodium-dependent effects of melatonin on membrane potential of neonatal rat pituitary cells. Endocrinology 1992;131:939-46.
27. Balik A, Kretschmannova K, Mazna P, et al. Melatonin action in neonatal gonadotrophs. Physiol Res 2004;53:S153-66.