Morphological and endocrinological characteristics of the endocrine systems in Wistar Hannover GALAS rats showing spontaneous dwarfs

Journal of Toxicologic Pathology

Volumn 17, Issue 3, 2004, Pages 197-203

  Doi, Takuya ^a   Namiki, Masato ^a   Ashina, Michiko ^a   Toyota, Naoto ^a   Kokoshima, Hiroko ^a   Kanno, Takeshi ^a   Wako, Yumi ^a   Tayama, Maimi ^b   Nakashima, Yukihiro ^b   Nasu, Masahiro ^b   Tsuchitani, Minoru ^a  

^a MITSUBISHI CHEMICAL CORPORATION   (Japan)

^b Panapharm Laboratories Co Ltd   (Japan)

Author keywords

Dwarf; Primary hypothyroidism; Thyroxine; Triiodothyronine; TSH; Wistar Hannover GALAS rat

Indexed keywords

EID: 23044493444     PISSN: 09149198     EISSN: None     Source Type: Journal    
DOI: 10.1293/tox.17.197     Document Type: Article

References (15)

1. DeLellis RA. Hypothyroidism. In: Robbins pathologic basis of disease, 4th ed., RS Cotran, V Kumar, and SL Robbins (eds), Philadelphia: WB Saunders, 1218-1220, 1989.
2. Kim PS, Ding M, Menon S, Jung CG, Cheng JM, Miyamoto T, Li B, Furudate S, and Augi T. A missence mutation G2320R in the thyroglobulin gene causes non-goitrous congenital primary hypothyroidism in the WIC-rdw rat. Mol Endocrinol 2000; 14: 1944-1953.
3. Beamer WJ, Eicher EM, Maltias LJ, and Southard JL. Inherited primary hypothyroidism in mice. Science 1981; 212: 61-63.
4. Beamer WG, Maltias LJ, DeBeats MH, and Eicher EM. Inherited congenital goiter in mice. Endocrinology 1987; 120: 838-840.
5. Umezu M, Kagabu S, Jiang J, and Sato E. Evaluation and characterization of congenital hypothyroidism in rdw dwarf rats. Lab Anim Sci 1998; 48: 496-501.
6. Shimoi A, Kuwayama C, Miyauchi M, Kakinuma C, Kamiya M, Harada T, Ogihara T, Kurokawa M, and Mizuguchi K. Vacuolar change in the thyroid follicular cells in BrlHan:WIST@(GALAS) rats. J Toxcol Pathol 2001; 14: 253-257.
7. Koto M, Sato T, Okamoto M, and Adachi J. rdw rats, a new hereditary dwarf model in the rat. Exp Anim 1988; 37: 21-30.
8. Stein SA, Shanklin DR, Krulich L, Roth MG, Chubb CM, and Adams PM. Evaluation and characterization of the hyt/hyt hypothyroid mouse. II. Abnormalities of TSH and the thyroid gland. Neuroendocrinology 1989; 49: 509-519.
9. Mayerhofer A, Amador AG, Beamer WG, and Bartke A. Ultrastructural aspects of the goiter in cog/cog mice. J Hered 1988; 79: 200-203.
10. Sakai Y, Yamashina S, and Furudate S. Missing secretory granules, dilated endoplasmic reticulum, and nuclear dislocation in the thyroid gland of rdw rats with hereditary dwarfism. Anat Rec 2000; 259: 60-66.
11. Stein SA, Oates EL, Hall CR, Grumbles RM, Fernandes LM, Taylor NA, Puett D, and Jin S. Identification of a point mutation in the thyrotropin receptor of the hyt/hyt hypothyroid mouse. Mol Endocrinol 1994; 8: 129-138.
12. Kim PS, Hossain SA, Park YN, Lee I, Yoo SE, and Arvan P. A single amino acid change in the acethylcholinesterase-like domain of thyroglobulin causes congenital goiter with hypothyroidism in the cog/cog mouse: a model of human endoplasmic reticulum storage diseases. Proc Natl Acad Sci USA 1998; 95: 9909-9913.
13. Stahl JH, Kendall SK, Brinkmeier ML, Greco TL, Watkins-Chow DE, Campos-Barros A, Lloyd RV, and Camper SA. Thyroid hormone is essential for pituitary somatotropes and lactotropes. Endocrinology 1999; 140: 1884-1892.
14. Samuels HH and Shapiro LE. Thyroid hormone stimulates de novo growth hormone synthesis in cultured GH1 cells: evidence for the accumulation of a rate limiting RNA species in the induction process. Proc Natl Acad Sci USA 1976; 73: 3369-3373.
15. Martial JA, Baxter JD, Goodman HM, and Seeburg PH. Regulation of growth hormone messenger RNA by thyroid and glucocorticoid hormones. Proc Natl Acad Sci USA 1977; 74: 1816-1820.