Impact of continuous and pulsatile insulin delivery on net hepatic glucose uptake

American Journal of Physiology - Endocrinology and Metabolism

Volumn 289, Issue 2 52-2, 2005, Pages

  Grubert, Jaime M ^a   Lautz, Margaret ^a   Lacy, D Brooks ^a   Moore, Mary C ^a   Farmer, Ben ^a   Penaloza, Angelina ^a   Cherrington, Alan D ^a   McGuinness, Owen P ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cell; Glycogen; Insulin secretion

Indexed keywords

INSULIN; SOMATOSTATIN; TRACER;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; EXTRACTION; GLUCOSE CLAMP TECHNIQUE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HORMONAL REGULATION; HYPERGLYCEMIA; INFUSION; INSULIN BLOOD LEVEL; INSULIN RELEASE; LIVER; LIVER METABOLISM; NONHUMAN; OSCILLATION; PANCREAS; PRIORITY JOURNAL; TECHNIQUE;

ANIMALS; BLOOD GLUCOSE; DOGS; DRUG ADMINISTRATION SCHEDULE; GLUCOSE; HYPERGLYCEMIA; INSULIN; LIVER; PERIODICITY; STATISTICS;

EID: 23044486762     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00567.2004     Document Type: Article

References (31)

1. Adkins-Marshall BA, Myers SR, Hendrick GK, Williams PE, Triebwasser K, Floyd B, and Cherrington AD. Interaction between insulin and glucose-delivery route in regulation of net hepatic glucose uptake in conscious dogs, Diabetes 39: 87-95, 1990.
2. Bratusch-Marrain PR, Komjati M, and Waldbausl WK. Efficacy of pulsatile vs. continuous insulin administration on hepatic glucose production and glucose utilization in type I diabetic humans. Diabetes 35: 922-926, 1986.
3. Cherrington AD, Edgerton D, and Sindelar DK. The direct and indirect effects of insulin on hepatic glucose production in vivo. Diabetologia 41: 987-996, 1998.
4. Courtney CH, Atkinson AB, Ennis CN, Sheridan B, and Bell PM. Comparison of the priming effects of pulsatile and continuous insulin delivery on insulin action in man. Metabolism 52: 1050-1055, 2003.
5. Goodner CJ, Hom FG, and Koerker DJ. Hepatic glucose production oscillates in synchrony with the islet secretory cycle in fasting rhesus monkeys. Science 215: 1257-1260, 1982.
6. Jaspan JB, Lever E, Polonsky KS, and Van Cauter E. In vivo pulsatility of pancreatic islet peptides. Am J Physiol Endocrinol Metab 251: E215-E226, 1986.
7. Kerner W, Bruckel J, Zier H, Arias P, Thun C, Moncayo R, and Pfeiffer EF. Similar effects of pulsatile and constant intravenous insulin delivery. Diabetes Res Clin Pract 4: 269-274, 1988.
8. Lang DA, Matthews DR, Peto J, and Turner RC. Cyclic oscillations of basal plasma glucose and insulin concentrations in human beings. N Engl J Med 301: 1023-1027, 1979.
9. Leevy CM, Mendenhall CL, Lesko W, and Howard MM. Estimation of hepatic blood flow with indocyanine green. J Clin Invest 41: 1169-1179, 1962.
10. Matthews DR, Hermansen K, Connolly AA, Gray D, Schmitz O, Clark A, Orskov H, and Turner RC. Greater in vivo than in vitro pulsatility of insulin secretion with synchronized insulin and somatostatin secretory pulses. Endocrinology 120: 2272-2278, 1987.
11. Matthews DR, Naylor BA, Jones RG, Ward GM, and Turner RC. Pulsatile insulin has greater hypoglycemic effect than continuous delivery. Diabetes 32: 617-621, 1983.
12. McGuinness OP. Assessment of insulin action in vivo. Methodological considerations. Semin Reprod Endocrinol 12: 143-148, 1994.
13. McGuinness OP, Fujiwara T, Murrell S, Bracy D, Neal D, O'Connor D, and Cherrington AD. Impact of chronic stress hormone infusion on hepatic carbohydrate metabolism in the conscious dog. Am J Physiol Endocrinol Metab 265: E314-E322, 1993.
14. Morgan CR and Lazarow AL. Immunoassay of insulin: two antibody system. Plasma insulin of normal, subdiabetic, and diabetic rats. Am J Med 257: 415-419, 1963.
15. Myers SR, McGuinness OP, Neal DW, and Cherrington AD. Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration. J Clin Invest 87: 930-939, 1991.
16. Pagliassotti MJ, Holste LC, Moore MC, Neal DW, and Cherrington AD. Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog. J Clin Invest 97: 81-91, 1996.
17. Paolisso G, Scheen AJ, Giugliano D, Sgambato S, Albert A, Varricchio M, D'Onofrio F, and Lefebvre PJ. Pulsatile insulin delivery has greater metabolic effects than continuous hormone administration in man: importance of pulse frequency. J Clin Endocrinol Metab 72: 607-615, 1991.
18. Paolisso G, Scheen AJ, Verdin EM, Luyckx AS, and Lefebvre PJ. Insulin oscillations per se do not affect glucose turnover parameters in normal man. J Clin Endocrinol Metab 63: 520-525, 1986.
19. Paolisso G, Sgambato S, Passariello N, Scheen A, D'Onofrio F, and Lefebvre PJ. Greater efficacy of pulsatile insulin in type I diabetics critically depends on plasma glucagon levels. Diabetes 36: 566-570, 1987.
20. Rebrin K, Steil GM, Mittelman SD, and Bergman RN. Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs. J Clin Invest 98: 741-749, 1996.
21. Satake S, Moore MC, Igawa K, Converse M, Farmer B, Neal DW, and Cherrington AD. Direct and indirect effects of insulin on glucose uptake and storage by the liver. Diabetes 51: 1663-1671, 2002.
22. Schmitz O, Arnfred J, Nielsen OH, Beck-Nielsen H, and Orskov H. Glucose uptake and pulsatile insulin infusion: euglycaemic clamp and [3-3H]glucose studies in healthy subjects. Acta Endocrinol (Copenh) 113: 559-563, 1986.
23. Shulman GI, Lacy WW, Liljenquist JE, Keller U, Williams PE, and Cherrington AD. Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog. J Clin Invest 65: 496-505, 1980.
24. Shulman GI, Williams PE, Liljenquist JE, Lacy WW, Keller U, and Cherrington AD. Effect of hyperglycemia independent of changes in insulin or glucagon on lipolysis in the conscious dog. Metabolism 29: 317-320, 1980.
25. Sindelar D, Chu C, Venson P, Donahue E, Neal D, and Cherrington A. Basal hepatic glucose production is regulated by the portal vein insulin concentration. Diabetes 47: 523-529, 1998.
26. Sindelar DK, Balcom JH, Chu CA, Neal DW, and Cherrington AD. A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog. Diabetes 45: 1594-1604, 1996.
27. Sindelar DK, Chu CA, Neal DW, and Cherrington AD. Interaction of equal increments in arterial and portal vein insulin on hepatic glucose production in the dog. Am J Physiol Endocrinol Metab 273: E972-E980, 1997.
28. Sindelar DK, Chu CA, Rohlie M, Neal DW, Swift LL, and Cherrington AD. The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog. Diabetes 46: 187-196, 1997.
29. Somogyi M. Determination of blood sugar. J Biol Chem 160: 69-73, 1945.
30. Stagner JI, Samols E, and Weir GC. Sustained oscillations of insulin, glucagon, and somatostatin from the isolated canine pancreas during exposure to a constant glucose concentration. J Clin Invest 65: 939-942, 1980.
31. Steiner KE, Williams PE, Lacy WW, and Cherrington AD. Effects of insulin on glucagon-stimulated glucose production in the conscious dog. Metabolism 39: 1325-1333, 1990.