Animal model of unilateral ventilator-induced lung injury

Intensive Care Medicine

Volumn 31, Issue 3, 2005, Pages 487-490

  Farre, Ramon ^a   Granell, Susana ^b   Rotger, Mar ^a   Serrano Mollar, Anna ^b   Closa, Daniel ^b   Navajas, Daniel ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

Author keywords

High volume ventilation; Lung edema; Lung injury; Lung overstretch; Mechanical ventilation; Selective lung ventilation

Indexed keywords

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL; ARTICLE; ARTIFICIAL VENTILATION; COMPARATIVE STUDY; DISEASE MODEL; MALE; POSITIVE END EXPIRATORY PRESSURE; PRESSURE; RAT; TIDAL VOLUME; WISTAR RAT;

ANIMALS; DISEASE MODELS, ANIMAL; MALE; POSITIVE-PRESSURE RESPIRATION; PRESSURE; RATS; RATS, WISTAR; RESPIRATION, ARTIFICIAL; RESPIRATORY DISTRESS SYNDROME, ADULT; TIDAL VOLUME;

EID: 23044469638     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-004-2534-8     Document Type: Article

References (14)

1. Dreyfuss D, Soler P, Saumon G (1995) Mechanical ventilation-induced pulmonary edema. Interaction with previous lung alterations. Am J Respir Crit Care Med 151:1568–1575
2. Chiumello D, Pristine G, Slutsky AS (1999) Mechanical ventilation affects local and systemic cytokines in an animal model of acute respiratory distress syndrome. Am J Respir Crit Care Med 160:109–116
3. Schortgen F, Bouadma L, Joly-Guillou M-L, Ricard J-D, Dreyfuss D, Saumon G (2004) Infectious and inflammatory dissemination are affected by ventilation strategy in rats with unilateral pneumonia. Intensive Care Med 30:693–701
4. Pinhu L, Whitehead T, Evans T, Griffiths M (2003) Ventilator-associated lung injury. Lancet 361:332–340
5. Plotz FB, Slutsky AS, van Vught AJ, Heijnen CJ (2004) Ventilator-induced lung injury and multiple system organ failure: a critical review of facts and hypotheses. Intensive Care Med 30:1865–1872
6. Uhlig S, Ranieri M, Slutsky AS, Dreyfuss D, Ricard J-D, Saumon G (2004) Biotrauma Hypothesis of Ventilator-induced Lung Injury. Am J Respir Crit Care Med 169:314–316
7. Farre R, Granell S, Rotger M, Serrano-Mollar A, Closa D, Navajas D (2004) Animal model of unilateral ventilator induced lung injury. Intensive Care Med 30 [Suppl 1]:S43
8. Parker JC, Townsley MI (2004) Evaluation of lung injury in rats and mice. Am J Physiol CelMol Physiol 286:L231–L246
9. Quinn DA, Moufarrej RK, Volokhov A, Hales CA (2002) Interactions of lung stretch, hyperoxia, and MIP-2 production in ventilator-induced lung injury. J Appl Physiol 93:517–525
10. Granell S, Serrano-Mollar A, Folch-Puy E, Navajas D, Farre R, Bulbena O, Closa D (2004) Oxygen in the alveolar air space mediates lung inflammation in acute pancreatitis. Free Radic Biol Med 37:1640–1647
11. Sinclair SE, Kregenow DA, Lamm WJE, Starr IR, Chi EY, Hlastala MP (2002) Hypercapnic acidosis is protective in an in vivo model of ventilator-induced lung injury. Am J Respir Crit Care Med 166:403–408
12. Laffey JG, O’Croinin D, McLoughlin P, Kavanagh BP (2004) Permissive hypercapnia-role in protective lung ventilatory strategies. Intensive Care Med 30:347–356
13. Kotani M, Kotani T, Li Z, Silbajoris R, Piantadosi CA, Huang Y-CT (2004) Reduced inspiratory flow attenuates IL-8 release and MAPK activation of lung overstretch. Eur Respir J 24:238–246
14. D’Angelo E, Pecchiari M, Saetta M, Balestro E, Milic-Emili J (2004) Dependence of lung injury on inflation rate during low-volume ventilation in normal open-chest rabbits. J Appl Physiol 97:260–268