Scopolamine patch to prevent seasickness: Clinical response vs. plasma concentration in sailors

Aviation Space and Environmental Medicine

Volumn 76, Issue 8, 2005, Pages 766-770

  Gil, Amnon ^a   Nachum, Zohar ^a   Dachir, Shlomit ^b   Chapman, Shira ^b   Levy, Aharon ^b   Shupak, Avi ^a   Adir, Yochai ^a   Tal, Dror ^a  

^a ISRAEL NAVAL MEDICAL INSTITUTE   (Israel)

^b ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

Author keywords

Adverse reactions; Efficacy; Motion sickness

Indexed keywords

SCOPOLAMINE;

ADULT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DROWSINESS; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG EFFICACY; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL CONCENTRATION; MOTION SICKNESS; PATIENT COMPLIANCE; RADIORECEPTOR ASSAY; REPRODUCIBILITY; SAILOR; SYMPTOMATOLOGY; TREATMENT OUTCOME; VISUAL IMPAIRMENT; XEROSTOMIA;

ABSORPTION; ADMINISTRATION, CUTANEOUS; ADOLESCENT; ADULT; HUMANS; MALE; MIDDLE AGED; MILITARY PERSONNEL; MOTION SICKNESS; MUSCARINIC ANTAGONISTS; SCOPOLAMINE; TREATMENT OUTCOME;

EID: 23044456280     PISSN: 00956562     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Attias J, Gordon C, Ribak J, et al. Efficacy of transdermal scopolamine against seasickness: a 3-day study at sea. Aviat Space Environ Med 1987; 58:60-2.
2. Brown L, Langer R. Transdermal delivery of drugs. Annu Rev Med 1988; 39:221-9.
3. Chandrasekaran SK, Bayne W, Shaw JE. Pharmacokinetics of drug permeation through human skin. J Pharm Sci 1978; 67:1370-4.
4. Cintron NM, Chen YM. A sensitive radioreceptor assay for determining scopolamine concentrations in plasma and urine. J Pharm Sci 1987; 76:328-32.
5. Clissold SP, Heel RC. Transdermal hyoscine (scopolamine). A preliminary review of its pharmacodynamic properties and therapeutic efficacy. Drugs 1985; 29:189-207.
6. Crampton GH, ed. Motion and space sickness. Boca Raton, FL: CRC Press; 1990:153-78, 411-41.
7. Doweck I, Dachir S, Spitzer O, et al. Rate of absorption of scopolamine after application of scopoderm-TTS [Abstract]. Aviat Space Environ Med 1995; 66:467.
8. Ensing K, in't Hout WG, Halma, P, et al. Development and application of a radioreceptor assay for scopolamine. Arzneimittelforschung 1988; 38:106-11.
9. Graybiel A, Knepton J, Shaw J. Prevention of experimental motion sickness by scopolamine absorbed through the skin. Aviat Space Environ Med 1976; 47:1096-100.
10. Hardman JG, Limbird LE, Gilman AG, eds. Goodman and Gilman's the pharmacological basis of therapeutics, 10th ed. New York: McGraw-Hill; 2001:162-71.
11. Nachum Z, Shahal B, Shupak A, et al. Scopolamine bioavailability in combined oral and transdermal delivery. J Pharmacol Exp Ther 2001; 296:121-3.
12. Noy S, Shapira S, Zilbiger A, Ribak J. Transdermal therapeutic system scopolamine (TTSS), dimenhydrinate, and placebo - a comparative study at sea. Aviat Space Environ Med 1984; 55:1051-4.
13. Parrott AC. Transdermal scopolamine: a review of its effects upon motion sickness, psychological performance, and physiological functioning. Aviat Space Environ Med 1989; 60:1-9.
14. Pingree BJW, Pethybridge RJ. A comparison of the efficacy of cinnarizine with scopolamine in the treatment of seasickness. Aviat Space Environ Med 1994; 65:597-605.
15. Price N, Schmitt LG, Shaw JE. Transdermal delivery of scopolamine for prevention of motion-induced nausea in rough seas. Clin Ther 1979; 2:258-62.
16. Pyykko I, Schalen L, Jantti V. Transdermally administered scopolamine vs. dimenhydrinate. I. Effect on nausea and vertigo in experimentally induced motion sickness Acta Otolaryngol 1985; 99:588-96.
17. Reason JT, Brand JJ. Motion sickness. London: Academic Press; 1975:38-82.
18. Shaw JE, Chandrasekaran SK. Transdermal therapeutic systems. In: Prescott LF, Nimmo WS, eds. Drug absorption. The proceedings of the International Conference on Drug Absorption, September 1979, Edinburgh. New York: ADIS Press; 1981:186-93.
19. Shaw JE, Urquhart J. Transdermal drug administration - a nuisance becomes an opportunity. Br Med J 1981; 283:875-6.
20. Wiker SF, Kennedy RS, McCauley ME, Pepper RL. Reliability, validity and application of an improved scale for assessment of motion sickness severity. Washington, DC: U.S. Dept. of Transportation, U.S. Coast Guard, Office of Research and Development; 1979. Report No. CG-D-29-79.