Molecular biology: Regulation of X-chromosome counting by Tsix and Xite sequences

Science

Volumn 309, Issue 5735, 2005, Pages 768-771

  Lee, Jeannie T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA SEQUENCES; GENETIC ENGINEERING; LIVING SYSTEMS STUDIES; MOLECULAR BIOLOGY;

DOSAGE; INACTIVATION; MAMMALS; MUTATIONS;

CHROMOSOMES;

CHROMOSOME; MOLECULAR ANALYSIS;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; EMBRYO; FEMALE; GENE; GENE MUTATION; GENE SEQUENCE; HOMOZYGOSITY; HYPOTHESIS; KARYOTYPE 46,XX; KARYOTYPE 46,XY; KNOCKOUT MOUSE; MALE; MAMMAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE; TRANSGENIC MOUSE; TSIX GENE; X CHROMOSOME; X CHROMOSOME INACTIVATION; XITE GENE; ANIMAL; BIOLOGICAL MODEL; BLASTOCYST; CELL DEATH; CELL DIFFERENTIATION; CELL LINE; CHROMOSOME; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DOSAGE; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PHYSIOLOGY;

ANIMALIA; MAMMALIA; MUS MUSCULUS;

SPACER DNA; TSIX TRANSCRIPT, MOUSE; UNTRANSLATED RNA; X (INACTIVE) SPECIFIC TRANSCRIPT (XIST); X (INACTIVE)-SPECIFIC TRANSCRIPT (XIST);

ANIMALS; BASE SEQUENCE; BLASTOCYST; CELL DEATH; CELL DIFFERENTIATION; CELL LINE; CHROMOSOMES, MAMMALIAN; DNA, INTERGENIC; DOSAGE COMPENSATION, GENETIC; FEMALE; GENE DOSAGE; GENE SILENCING; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MODELS, GENETIC; RNA, UNTRANSLATED; X CHROMOSOME;

EID: 23044455689     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1113673     Document Type: Article

References (15)

1. M. F. Lyon, Nature 190, 372 (1961).
2. J. T. Lee, N. Lu, Cell 99, 47 (1999).
3. Y. Ogawa, J. T. Lee, Mol. Cell 11, 731 (2003).
4. M. F. Lyon, Biol. Rev. Camb. Philos. Soc. 47, 1 (1972).
5. S. Rastan, J. Embryol. Exp. Morphol. 78, 1 (1983).
6. J. T. Lee, W. M. Strauss, J. A. Dausman, R. Jaenisch, Cell 86, 83 (1996).
7. E. Heard, F. Mongelard, D. Arnaud, P. Avner, Mol. Cell. Biol. 19, 3156 (1999).
8. J. T. Lee, N. F. Lu, Y. Han, Proc. Natl. Acad Sci. U.S.A. 96, 3836 (1999).
9. P. Clerc, P. Avner, Nat. Genet. 19, 249 (1998).
10. C. Morey et al., EMBO J. 23, 594 (2004).
11. J. T. Lee, Nat. Genet. 32, 195 (2002).
12. C. J. Brown et al., Cell 71, 527 (1992).
13. G. D. Penny, G. F. Kay, S. A. Sheardown, S. Rastan, N. Brockdorff, Nature 379, 131 (1996).
14. N. Stavropoulos, R. K. Rowntree, J. T. Lee, Mol. Cell. Biol. 25, 2757 (2005).
15. I thank Y. Ogawa for pSx7 and pXite (pDNT1); N. Xu for pTsx; L F. Zhang, D. E. Cohen, N. Xu, B. K. Sun, R. J. Spencer, D. Tian, and J. E. Kirby for critical reading; and all lab members for stimulating discussion. J.T.L. is an Investigator of the Howard Hughes Medical Institute and is supported by the NIH (RO1-GM58839).