Process enabling and the scale-up of 6β-hydroxymethylsulbactam and its esters

Organic Process Research and Development

Volumn 9, Issue 4, 2005, Pages 432-439

  Norris, Timothy ^a   Ripin, David H Brown ^a   Ahlijanian, Paul ^a   Andresen, Brian M ^a   Barrila, Mark T ^a   Colon Cruz, Roberto ^a   Couturier, Michel ^a   Hawkins, Joel M ^a   Loubkina, Ioulia V ^a   Rutherford, Jennifer ^a   Stickley, Kurt ^a   Wei, Lulin ^a   Vollinga, Roel ^a,b   De Pater, Robert ^a,b   Maas, Peter ^a,c   De Lange, Ben ^a,c   Callant, Dominique ^a,c   Konings, Jeroen ^a,c   Andrien, Jean ^a,c   Versleijen, Jos ^a,d   Hulshof, Jos ^a,d   Daia, Elena ^a,e   Johnson, Natalka ^a,e   Sung, David W L ^a,e   more..

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b DSM Pharmaceutical Products   (Netherlands)

^c Catalysis and Development   (Netherlands)

^d Syncom BV   (Netherlands)

^e SynProTec Limited   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 23044452492     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op050047a     Document Type: Article

References (30)

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15. Silicone oil was used to prevent drying and caking of the slurry during the cracking operation.
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29. Norris, T.; Johnson, N.; Daia, D.; Dowdeswell, C. Manuscript in preparation.
30. 2EtN results in 9:1 selectivity favoring the β-hydroxymethy sulbactam product, while the use of smaller bases results in primarily the α-hydroxymethyl sulbactam. This hydrogenation has been carefully studied, and details will be published separately. Rutherford, J. L.; Hawkins, J. M.; Norris, T.; Ripin, D. H. B.; Colon-Cruz, R.; Stickley, K.; Versleijen, J. Manuscript in preparation.