Comparison of the adsorption capacities of an activated-charcoal-yogurt mixture versus activated-charcoal-water slurry in vivo and in vitro

Clinical Toxicology

Volumn 43, Issue 4, 2005, Pages 269-275

  Hoegberg, Lotte Christine Groth ^a,b   Christophersen, Anne Bolette ^a   Christensen, Hanne Rolighed ^a   Angelo, Helle Riis ^a  

^a BISPEBJERG HOSPITAL   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Absorption reduction; Activated charcoal; Adsorption; Gastric decontamination; Intoxication; Paracetamol; Poisoning; Yogurt

Indexed keywords

ACTIVATED CARBON; PARACETAMOL; WATER; YOGHURT;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ADSORPTION; DRUG BLOOD LEVEL; DRUG COMPARISON; DRUG MIXTURE; FEMALE; HUMAN; MALE; PALATABILITY; RANDOMIZED CONTROLLED TRIAL; VISUAL ANALOG SCALE;

ACETAMINOPHEN; ADSORPTION; ADULT; ANALGESICS, NON-NARCOTIC; ANTIDOTES; AREA UNDER CURVE; CHARCOAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-OVER STUDIES; FEMALE; HALF-LIFE; HUMANS; MALE; SPECTROPHOTOMETRY, ULTRAVIOLET; TASTE; WATER; YOGURT;

EID: 23044440122     PISSN: 07313810     EISSN: None     Source Type: Journal    
DOI: 10.1081/CLT-200066067     Document Type: Article

References (26)

1. Hoegberg LCG, Angelo HR, Christophersen AB, Christensen HR. Effect of ethanol and pH on the adsorption of paracetamol to high surface activated charcoal, in vitro studies. J Toxicol, Clin Toxicol 2002; 40:59-67.
2. Andersen AH. Experimental studies on the pharmacology of activated charcoal. I. Adsorption power of charcoal in aqueous solutions. Acta Pharm Toxicol 1946; 2:69-78.
3. Holt LE, Holz PD. The black bottle. J Pediatr 1963; 63:306-314.
4. Piccioni AL. Activated charcoal as an antidote for poisonings. Am J Hosp Pharm 1967; 24:38-39.
5. Piccioni AL. Management of acute poisonings with activated charcoal. Am J Hosp Pharm 1971; 28:62-64.
6. Cooney DO. Activated Charcoal in Medical Applications. New York, NY: Marcel Dekker, 1995.
7. Bond GR. The role of activated charcoal and gastric emptying in gastrointestinal decontamination: a state-of-the-art review. Ann Emerg Med 2002; 39:273-286.
8. Arena JM. Gastric lavage, ipecac, or activated charcoal? JAMA 1970; 212:328.
9. Levy G, Soda DM, Lampman TA. Inhibition by ice cream of the antidotal efficacy of activated charcoal. Am J Hosp Pharm 1975; 32:289-291.
10. Oderda GM. Letter: activated charcoal and ice cream. Am J Hosp Pharm 1975; 32:562.
11. Eisen TF, Grbcich PA, Lacouture PG, Shannon MW, Woolf A. The adsorption of salicylates by a milk chocolate-charcoal mixture. Ann Emerg Med 1991; 20:143-146.
12. Lamminpää A, Vilska J, Hoppu K. Medical charcoal for a child's poisoning at home: availability and success of administration in Finland. Human Exp Toxicol 1993; 12:29-32.
13. Guenthan Skokan E, Junkins EP, Corneli HM, Schunk JE. Taste test: children rate flavoring agents used with activated charcoal. Arch Pediatr Adolesc Med 2001; 155:683-686.
14. Rangan C, North SP, Hamilton R, Ingels M, Clark RF. Treatment of paracetamol ingestion with a superactive charcoal-cola mixture. Ann Emerg Med 2001; 37:55-58.
15. Cheng M, Robertson WO. Charcoal "flavored" ice cream. Vet Hum Toxicol 1989; 31:332 (Abstract).
16. Teubner DJO. Absence of ice-cream interference with the adsorption of paracetamol onto activated charcoal. Emerg Med 2000; 12:326-328.
17. Hoegberg LCG, Angelo HR, Christophersen AB, Christensen HR. The effect of food and ice cream on the adsorption capacity of paracetamol to high surface activated charcoal, in vitro studies. Pharmacol Toxicol 2003; 93:233-237.
18. Cordonnier JA, Van den Heede MA, Heyndrickx AM. In vitro adsorption of tilidine HCl by activated charcoal. J Toxicol, Clin Toxicol 1986; 24:503-517.
19. Jones A, Dargan P. Churchill's Pocketbook of Toxicology. London: Churchill Livingstone, 2001:12.
20. Christophersen AB, Levin D, Hoegberg LCG, Angelo HR, Kampmann JP. Activated charcoal alone or after gastric lavage: early presenting intoxications with large ingestions, a volunteer study. Br J Clin Pharmacol 2002; 53:312-317.
21. Roberts JR, Gracely EJ, Schoffstall JM. Advantage of high-surface-area charcoal for gastrointestinal decontamination in a human paracetamol ingestion model. Acad Emerg Med 1997; 4:167-174.
22. Altman DG. Practical Statistics for Medical Research. London, UK: Chapman and Hall, 1991.
23. Tsitoura A, Atta-Politou J, Koupparis MA. In vitro adsorption study of fluoxetine onto activated charcoal at gastric and intestinal pH using high performance liquid chromatography with fluorescence detector. J Toxicol, Clin Toxicol 1997; 35:269-276.
24. Eisen TF, Lacouture PG, Woolf A. The palatability of a new milk chocolate-charcoal mixture in children. Vet Hum Toxicol 1988; 30:351-352 (Abstract).
25. de Neve R. Antidotal efficacy of activated charcoal in presence of jam, starch and milk. Am J Hosp Pharm 1976; 33:965-966.
26. Shannon M. Ingestion of toxic substances by children. N Engl J Med 2000; 342:186-191.