Protective effect of melatonin and omeprazole against alendronat-induced gastric damage

Digestive Diseases and Sciences

Volumn 50, Issue 8, 2005, Pages 1506-1512

  Sener, Goksel ^a   Goren, Figen Onuk ^b   Ulusoy, Nefise B ^b   Ersoy, Yasemin ^a   Arbak, Serap ^a   Dülger, Gül Ayanoǧlu ^a  

^a MARMARA UNIVERSITY   (Turkey)

^b AMERICAN HOSPITAL   (Turkey)

Author keywords

Alendronat; Glutathione; Lipid peroxidation; Melatonin; Myeloperoxidase; Omeprazole

Indexed keywords

ALENDRONIC ACID; FREE RADICAL; GLUTATHIONE; MELATONIN; MYELOPEROXIDASE; OMEPRAZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; FEMALE; HISTOLOGY; LIGATION; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATION; PARAMETER; PRIORITY JOURNAL; RAT; STOMACH; STOMACH INJURY; STOMACH PH; STOMACH PROTECTION; STOMACH ULCER; TISSUE LEVEL;

ADMINISTRATION, ORAL; ALENDRONATE; ANIMALS; ANTI-ULCER AGENTS; ANTIOXIDANTS; FASTING; FEMALE; GASTRIC ACIDITY DETERMINATION; GASTROINTESTINAL DISEASES; INJECTIONS, INTRAPERITONEAL; MALE; MELATONIN; OMEPRAZOLE; RATS;

EID: 22944473008     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-005-2869-1     Document Type: Article

References (36)

1. Lanza F, Rack MF, Simon TJ, Lombardi A, Reyes R, Suryawanshi S: Effects of alendronate on gastric and duodenal mucosa. Am J Gastroenterol 93:753-757, 1998
2. Lanza FL, Hunt RH, Thomson AB, Provenza JM, Blank MA: Endoscopic comparison of esophageal and gastroduedenal effects of risedronate and alendronate in postmenopausal women. Gastroenterology 119:631-638, 2000
3. Graham DY, Malaty HM: Alendronate gastric ulcers. Alimen Pharmacol Ther 13:515-519, 1999
4. Graham DY: Excess gastric ulcers are associated with alendronate therapy. Letter to the editor. Am J Gastroenterol 93:1395-1396, 1998
5. Graham DY: What the gastroenterologist should know about the gastrointestinal safety profiles of bisphosphonates. Dig Dis Sci 47:1665-1678, 2002
6. Blank MA, Ems BL, Gibson GW, Myers WR, Berman K, Phipps RJ, Smith PN: Nonclinical model for assessing gastric effects of bisphosphonates. Dig Dis Sci 42:281-288, 1997
7. Lowe CE, Depew TW, Vanner SJ, Paterson WG, Meddings JB: Upper gastrointestinal toxicity of alendronate. Am J Gastroenterol 95:634-640, 2000
8. Elliot SN, McKnight W, Davies NM, MacNaughton WK, Wallace JL: Alendronate induces gastric injury and delays ulcer healing in rodents. Life Sci 62:77-91, 1998
9. Marshall JK, Rainsford KD, James C, Hunt RH: A randomized controlled trials to assess alendronate-associated injury of the gastrointestinal tract. Aliment Pharmacol Ther 14:1451-1457, 2000
10. Peter CP, Handt LK, Smith SM: Esophageal irritation due to alendronate sodium tablets. Dig Dis Sci 43:1998-2002, 1998
11. Şener G, Paskaloǧlu K, Arbak S, Hürdaǧ C, Ayanoǧlu-Dülger G: Protective effect of famotidine, omeprazole, and melatonin against acetylsalicylic acid-induced gastric damage in rats. Dig Dis Sci 46:318-330, 2001
12. Groen PC, Lubbe DF, Hirsch LJ, Daifotis A, Stephenson W, Freedholm D, Pryor-Tillotson S, Seleznick MJ, Pinkas H, Wang KK: Esophagitis associated with the use of alendronate. N Engl J Med 335:1016-1021, 1996
13. Tan DX, Poeggeler B, Reiter, RJ: The pineal hormone melatonin inhibits DNA adduct formation induced by the chemical carcinogen safrole in vivo. Cancer Lett 70:65-71, 1993
14. Sewerynek E, Melchiorri D, Reiter RJ: Lipopolysaccharide-induced hepatotoxicity is inhibited by the antioxidant melatonin. Eur J Pharmacol 293:327-334, 1995
15. Melchiorri D, Reiter RJ, Sewerynek E: Melatonin reduces kainate-induced lipid peroxidation in homogenates of different brain regions. FASEB J 9:1205-1210, 1995
16. 2 induced lipid peroxidation in homogenates of different rat brain regions. J Pineal Res 19:51-56, 1995
17. Hara M, Iigo M, Ohtani-Kanelo R, Nakamura N: Administration of melatonin and related indoles prevents exercise-induced cellular oxidative changes in rats. Biol Signals 6:90-100, 1997
18. Cuzzocrea S, Costantino G, Mazzon E, Micali A, De Sarro A, CaputiI AP: Beneficial effects of melatonin in a rat model of splanchnic artery occlusion and reperfusion. J Pineal Res 28:52-63, 2000
19. Reiter RJ, Tan DX, Osuna C, Gitto E: Actions of melatonin in the reduction of oxidative stress: a review. J Biomed Sci 7:444-458, 2000
20. Bandyopadhyay D, Biswas K, Bhattocharyya M, Reiter RJ, Banerjee RK: Gastric toxicity and mucosal ulceration induced by oxygen-derived reactive species: protection by melatonin. Curr Mol Med 1:501-513, 2001
21. Bandyopadhyay D, Bandyopadhyay A, Das PK, Reiter RJ: Melatonin protects against ulceration and increases the efficacy of ranitidine and omeprazole in reducing gastric damage. J Pineal Res 33:1-7, 2002
22. Bozkurt A, Yüksel M, Haklar G, Kurtel H, Yeǧen BÇ, Alican I: Adenosine protects against indomethacin-induced gastric damage in rats. Dig Dis Sci 43:1258-1263, 1998
23. Shay H, Sun DCY, Gruenstein R: A quantitative method for measuring spontaneous gastric secretion in the rat. Gastroenterology 26:906-913, 1954
24. Hillegas LM, Griswold DE, Brickson B, Albrightson-Winslow C: Assesment of myeloperoxidase activity in whole rat kidney. J Pharmacol Meth 24:285-295, 1990
25. Beutler E: Glutathione in red blood cell metabolism. In: A Manual of Biochemical Methods. New York, Grun & Stratton, 1975, pp 112-114
26. Beuge JA, Aust SD: Microsomal lipid peroxidation. Meth Enzymol 52:302-311, 1978
27. Lichtenberger, Romero JJ, Gibson GW, Blank MA: Effect of bisphosphonates on surface hydrophobicity and phosphatidylcholine concentration of rodent gastric mucosa. Dig Dis Sci 45:1792-1801, 2000
28. Parks DA, Granger DN: Ischemia-reperfusion injury: a radical view. Hepatology 8:680-682, 1988
29. Sullivan GW, Sarembock IJ, Linden J: The role of inflammation in vascular diseases. J Leukoc Biol 67:591-602, 2000
30. Kettle AJ, Winterbourn CC: Myeloperoxidase: a key regulator of neutrophil oxidant production. Redox Report 3:3-15, 1997
31. Reiter RJ, Acuno-Castroviejo D, Tan DX, Burkhardt S: Free radical-mediated molecular damage. Ann NY Acad Sci 939:200-215, 2001
32. Wallace JL, Dicay M, McKnight W, Bastaki S, Blank MA: N-Bisphosphonates cause gastric epithelial injury independent of effects on the microcirculation. Aliment Pharmacol Ther 13:1675-1682, 1999
33. Paller MS: Renal work, glutathione and susceptibility to free radical-mediated postischemic injury. Kidney Int 33:843-849, 1988
34. Ross D: Glutathione, free radicals and chemotherapeutic agents. Pharmacol Ther 37:231-249, 1988
35. Reiter JR, Tan DX, Sainz RM, Mayo JC, Lopez-Burillo S: Melatonin in reducing the toxicity and increasing the efficacy of drugs. J Pharm Pharmacol 54:1299-1321, 2002
36. Cardinali DP, Ladizesky MG, Boggio V, Cutrera RA, Mautalen C: Melatonin effects on bone: experimental facts and clicical perspectives. J Pineal Res 34:81-81, 2003