Tritiation of the cannabinoid receptor antagonist SR144528 involving lithium aluminum tritide reduction; assessment of the kinetic isotope effect by 3H-NMR

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 48, Issue 8, 2005, Pages 589-596

  Seltzman, Herbert H ^a   Foster, Matthew C ^a   Wyrick, Christopher D ^a   Burgess, Jason P ^a   Carroll, F Ivy ^a  

^a RTI INTERNATIONAL   (United States)

Author keywords

3H NMR; KIE; Lithium aluminum tritide; SR144528

Indexed keywords

ALUMINUM; LITHIUM; TRITIUM;

% REDUCTIONS; 3H-NMR; CANNABINOID RECEPTORS; KIE; KINETIC ISOTOPES EFFECTS; LITHIUM ALUMINUM TRITIDE; RECEPTOR ANTAGONISTS; SR144528; TRITIATION; TRITIDES;

HYDROGENATION;

5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; ALUMINUM DERIVATIVE; BENZOIC ACID DERIVATIVE; CANNABINOID RECEPTOR ANTAGONIST; ISOTOPE; LITHIUM ALUMINUM TRITIDE; LITHIUM DERIVATIVE; METHYL BENZOATE; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DRUG SYNTHESIS; HYDROGENATION; ISOTOPE LABELING; KINETIC ISOTOPE EFFECT; KINETICS; NUCLEAR MAGNETIC RESONANCE; RADIOACTIVITY; REDUCTION;

EID: 22944440949     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlcr.952     Document Type: Article

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