A double-blind comparison of intravenous ondansetron and placebo for preventing postoperative emesis in 1- to 24-month-old pediatric patients after surgery under general anesthesia

Anesthesia and Analgesia

Volumn 101, Issue 2, 2005, Pages 356-361

  Khalil, Samia N ^a,g   Roth, Andrew G ^b   Cohen, Ira T ^c   Simhi, Eli ^e   Ansermino, J Mark ^d   Bolos, Mariana E ^a   Coté, Charles J ^b   Hannallah, Raafat S ^c   Davis, Peter J ^e   Brooks, Peter B ^d   Russo, Mark W ^f   Anschuetz, Gaya C ^f   Blackburn, Linda M ^f  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^d BC CHILDREN S HOSPITAL   (Canada)

^e CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^f GLAXOSMITHKLINE   (United States)

^g MEMORIAL HERMANN HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ONDANSETRON; PLACEBO;

ADENOIDECTOMY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; GENERAL ANESTHESIA; HERNIORRHAPHY; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MYRINGOTOMY; ORCHIDOPEXY; ORTHOPEDIC SURGERY; PEDIATRIC SURGERY; PLASTIC SURGERY; POSTOPERATIVE VOMITING; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 22944434164     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ANE.0000155261.27335.29     Document Type: Article

References (19)

1. Palazzo MGA, Strunin L. Anesthesiology and emesis. I. Etiology. Can Anaesth Soc J 1984;31:178-87.
2. Patel RI, Hannallah RS. Anesthetic complications following pediatric ambulatory surgery: a 3-year study. Anesthesiology 1988;69:1009-12.
3. Watcha MF, White PF. Postoperative nausea and vomiting: its etiology, treatment, and prevention. Anesthesiology 1992;77: 162-84.
4. Gan TJ, Meyer T, Apfel C, et al. Consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg 2003;97:62-71.
5. Gold BS, Kitz DS, Lecky JH, Neuhaus JM. Unanticipated admission to the hospital following ambulatory surgery. JAMA 1989; 262:3008-10.
6. Fortier J, Chung F, Su J. Unanticipated admission after ambulatory surgery: a prospective study. Can J Anaesth 1998;45:612-9.
7. Rowley MP, Brown TC. Postoperative vomiting in children. Anaesth Intensive Care 1982;10:309-13.
8. Lerman J. Surgical and patient factors involved in postoperative nausea and vomiting. Br J Anaesth 1992;69:24S-32.
9. Kenny GN. Risk factors for postoperative nausea and vomiting. Anaesthesia 1994;49:6-10.
10. Hardy JF, Charest J, Girouard G, LePage Y. Nausea and vomiting after strabismus surgery in preschool children. Can Anaesth Soc J 1986;33:57-62.
11. Lerman J, Eustis S, Smith DR. Effect of droperidol pretreatment on postanesthetic vomiting in children undergoing strabismus surgery. Anesthesiology 1986;65:322-5.
12. Lin DM, Furst SR, Rodarte A. A double-blind comparison of metoclopramide and droperidol for prevention of emesis following strabismus surgery. Anesthesiology 1992;76:357-61.
13. Schreiner MS, Nicolson SC, Martin T, Whitney L. Should children drink before discharge from day surgery? Anesthesiology 1992;76:528-33.
14. Kovac AL, Pearman MG, Khalil SN, et al. Ondansetron prevents postoperative emesis in male outpatients. J Clin Anesth 1996;8: 644-51.
15. McKenzie R, Kovac A, O'Connor T, et al. Comparison of ondansetron versus placebo to prevent postoperative nausea and vomiting in women undergoing ambulatory gynecologic surgery. Anesthesiology 1993;78:21-8.
16. Davis PJ, McGowan FX Jr, Landsman I, et al. Effect of antiemetic therapy on recovery and hospital discharge time: a double-blind assessment of ondansetron, droperidol, and placebo in pediatric patients undergoing ambulatory surgery. Anesthesiology 1995; 83:956-60.
17. Khalil S, Rodarte A, Weldon BC, et al. Intravenous ondansetron in established postoperative emesis in children: S3A-381 study group. Anesthesiology 1996;85:270-6.
18. Patel RI, Davis PJ, Orr RJ, et al. Single-dose ondansetron prevents postoperative vomiting in pediatric outpatients. Anesth Analg 1997;85:538-45.
19. Davis A, Krige S, Moyes D. A double-blind randomized prospective study comparing ondansetron with droperidol in the prevention of emesis following strabismus surgery. Anaesth Intensive Care 1995;23:438-43.