Nonuniform response of skeletal muscle to heavy resistance training: Can bodybuilders induce regional muscle hypertrophy?

Journal of Strength and Conditioning Research

Volumn 14, Issue 1, 2000, Pages 102-113

  Antonio, Jose ^a  

^a UNIVERSITY OF NEBRASKA AT KEARNEY   (United States)

Author keywords

Exercise; Muscle fiber; Weight lifting

Indexed keywords

EID: 22844453959     PISSN: 10648011     EISSN: 15334295     Source Type: Journal    
DOI: 10.1519/00124278-200002000-00018     Document Type: Article

References (107)

1. Alway, S.E. Stretch induces non-uniform isomyosin expression in the quail anterior latissimus dorsi muscle. Anat. Rec. 237:1-7. 1993.
2. Alway, S.E., W.H. Grumbt, J. Stray-Gundersen, and WJ. Gonyea. Effects of resistance training on elbow flexors of highly competitive bodybuilders. J. Appl. Physiol. 72:1512-1521. 1992.
3. Alway, S.E., P.K. Winchester, M.E. Davis, and W.J. Gonyea. Regionalized adaptations and muscle fiber proliferation in stretch-induced enlargement. J. Appl. Physiol. 66:771-781. 1989.
4. Andersen, J.L., H. Klitgaard, and B. Saltin. Myosin heavy chain isoforms in single fibres from m. vastus lateralis of sprinters: Influence of training. Acta Physiol. Scand. 151:135-142. 1994.
5. Antonio, J., and W.J. Gonyea. Skeletal muscle fiber hyperplasia. Med. Sci. Sports Exerc. 25:1333-1345. 1993.
6. Antonio, J., and W.J. Gonyea. Muscle fiber splitting in stretch-enlarged avian muscle. Med. Sci. Sports Exerc. 26:973-977. 1994.
7. Antonio, J., and W.J. Gonyea. Ring fibres express ventricular myosin in stretch overloaded quail muscle. Acta Physiol. Scand. 152:429-430. 1994.
8. Barnett, C., V. Kippers, and P. Turner. Effects of variations of the bench press exercise on the EMG activity of five shoulder muscles. J. Strength Cond. Res. 9:222-227. 1995.
9. Billeter, R., H. Weber, H. Lutz, H. Howald, H.M. Eppen-berger, and E. Jenny. Myosin types in human skeletal muscle fibers. Histochemistry 65:249-259. 1980.
10. Brooke, M.H., and K.K. Kaiser. Three myosin ATPase systems: The nature of their pH lability and sulfhydryl dependence. J. Histochem. Cytochem. 18:670-672. 1970.
11. Brown, J.M.M., C. Solomon, and M. Paton. Further evidence of functional differentiation within biceps brachii. Electromyogr. Clin. Neurophysiol. 33:301-309. 1993.
12. Caiozzo, V.J., M.J. Baker, and K.M. Baldwin. Are skeletal muscle fibers obligated to follow the I “ IIA “ IIX “ IIB scheme of MyHC isoform plasticity? [Abstract]. Med. Sci. Sports Exerc. 30(Suppl.):S38. 1998.
13. Campos, G.R., T. Luecke, K. Toma, F.C. Hagerman, R.S Hik-ida, K. Ragg, W.J. Kraemer, and R.S. Staron. The effects of three different resistance training regimens on muscle fiber type composition [Abstract]. Med. Sci. Sports. Exerc. 30(Suppl.): S207. 1998.
14. Carey Smith, R., and O.M. Rutherford. The role of metabolites in strength training. Eur. J. Appl. Physiol. 71:332-336. 1995.
15. Cheek, D.B. The control of cell mass and replication. The DNA unit-A person 20-year study. Early Hum. Dev. 12:211-239. 1985.
16. Chilibeck, P.D., A.W. Calder, D.G. Sale, and C.E. Webber. A comparison of strength and muscle mass increases during resistance training in young women. Eur. J. Appl. Physiol. 77:170-175. 1998.
17. Colliander, E.B., and P.A. Tesch. Blood pressure in resistance-trained athletes. Can. J. Sport Sci. 13:31-34. 1988.
18. Crill, M., G. Campos, R.S. Staron, F.C. Hagerman, T. Luecke, T. Bailey, W.J. Kraemer, and R.S. Hickida. Different resistance training protocols and skeletal muscle fiber hypertrophy [Abtract]. Med. Sci. Sports Exerc. 30(Suppl.):S207. 1998.
19. Davies, J., D.F. Parker, O.M. Rutherford, and D.A. Jones. Changes in strength and cross-sectional area of the elbow flexors as a result of isometric strength training. Eur. J. Appl. Physiol. 57:667-670. 1988.
20. Dudley, G.A. Metabolic consequences of resistive-type exercise [Abstract]. Med. Sci. Sports Exerc. 20(Suppl.):S158-S161. 1988.
21. Elder, G.C.B., K. Bradbury, and R. Roberts. Variability of fiber type distributions within human muscles. J. Appl. Physiol. 53:1473-1480. 1982.
22. English, A.W., S.L. Wolf, and R.L. Segal. Compartmentali-zation of muscles and their motor nuclei: The partitioning hypothesis. Phys. Ther. 73:857-867. 1993.
23. Essen-Gustavsson, B., and P.A. Tesch. Glycogen and triglyceride utilization in relation to muscle metabolic characteristics in men performing heavy-resistance exercise. Eur. J. Appl. Physiol. 61:5-10. 1990.
24. Faulkner, J.A., D.R. Claflin, and K.K. McCully. Power output of fast and slow fibers from human skeletal muscles. in: Human Muscle Power. N.L. Jones, N. McCartney, and A.J. Mc-Comas, eds. Champaign, iL: Human Kinetics Publishers, 1986. pp. 81-90.
25. Feinstein, B., B. Lindegard, E. Nyman, and G. Wohlfart. Morphologic studies of motor units in normal human muscles. Acta Anat. 23:127-142. 1955.
26. Frontera, W.R., C.N. Meredith, K.P. O’Reilly, H.G. Knuttgen, and W.J. Evans. Strength conditioning in older men: Skeletal muscle hypertrophy and improved function. J. Appl. Physiol. 64:1038-1044. 1988.
27. Gardiner, P.F., B.J. Jasmin, and P. Corriveau. Rostrocaudal pattern of fiber-type changes in an overloaded rat ankle extensor. J. Appl. Physiol. 71:558-564. 1991.
28. Garrett, W.E., J.C. Califf, and F.H. Bassett. Histochemical correlates of hamstring injuries. Am. J. Sports Med. 12:98-103. 1984.
29. Glass, S.C., and T. Armstrong. Electromyographical activity of the pectoralis muscle during incline and decline bench presses. J. Strength Cond. Res. 11:163-167. 1997.
30. Gollnick, P.D., J. Karlsson, K. Piehl, and B. Saltin. Selective glycogen depletion in skeletal muscle fibers of man following sustained contraction. J. Physiol. 241:59-67. 1974.
31. Gotshalk, L.A., C.C. Loebel, B.C. Nindl, M. Putukian, W.J. Sebastianelli, R.U. Newton, K. Hakkinen, and W.J. Kraemer. Hormonal responses of multiset versus single set heavy resistance exercise protocols. Can. J. Appl. Physiol. 22:244-255. 1997.
32. Greenhaff, P.L., K. Bodin, K. Soderlund, and E. Hultman. Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis. Am. J. Physiol. 266:E725-E730. 1994.
33. Gryzlo, S.M., R.M. Patek, M. Pink, and J. Perry. Electromyographic analysis of knee rehabilitation exercises. J. Orthop. Sports Phys. Ther. 20:36-43. 1994.
34. Guglielmini, C., A.R. Paolini, and F. Conconi. Variations of serum testosterone concentrations after physical exercises of different duration. Int. J. Sports Med. 5:246-249. 1984.
35. Haggmark, T., E. Jansson, and B. Svane. Cross-sectional area of the thigh muscle in man measured by computed tomography. Scand. J. Clin. Lab. Invest. 38:355-360. 1978.
36. Hakkinen, K., K.L. Keskinen, M. Alen, P.V. Komi, and H. Kauhanen. Serum hormone concentrations during prolonged training in elite endurance-trained and strength-trained athletes. Eur. J. Appl. Physiol. 59:233-238. 1989.
37. Hakkinen, K., P.V. Komi, M. Alen, and H. Kauhanen. EMG, muscle fibre and force production during a 1 year training period in elite weight-lifters. Eur. J. Appl. Physiol. 56:419-427. 1987.
38. Hakkinen, K., A. Pakarinen, M. Alen, H. Kauhanen, and P.V. Komi. Neuromuscular and hormonal adaptations in athletes to strength training in two years. J. Appl. Physiol. 65:2406-2412. 1988.
39. Hakkinen, K., A. Pakarinen, R.U. Newton, and W.J. Kraemer. Acute hormone responses to heavy resistance lower and upper extremity exercise in young versus old men. Eur. J. Appl. Physiol. 77:312-319. 1998.
40. Heron, M.I., and F.J.R. Richmond. In-series fiber architecture in long human muscles. J. Morphol. 216:35-45. 1993.
41. Hisaeda, H., K. Miyagawa, S.-Y Kuno, T. Fukunaga, and I. Muraoka. Influence of two different modes of resistance training in female subjects. Ergonomics 39:842-852. 1996.
42. Housh, D.J., T.J. Housh, G.O. Johnson, and W.-K. Chu. Hypertrophic response to unilateral concentric isokinetic resistance training. J. Appl. Physiol. 73:65-70. 1992.
43. Jensen, J., H. Oftebro, B. Breigan, A. Johnsson, K. Ohlin, H.D. Meen, S.B. Stromme, and H.A. Dahl. Comparison of changes in testosterone concentrations after strength and endurance exercise in well trained men. Eur. J. Appl. Physiol. 63: 467-471. 1991.
44. Johnson, M.A., J. Polgar, D. Weightman, and D. Appleton. Data on the distribution of fibre types in thirty-six human muscles: An autopsy study. J. Neurol. Sci. 18:111-129. 1973.
45. Jorgensen, K., T. Nicholaisen, and M. Kato. Muscle fiber distribution, capillary density, and enzymatic activities in the lumbar paravertebral muscles of young men. Spine 18:1439-1450. 1993.
46. Kawakami, Y, T. Abe, S.-Y Kuno, and T. Fukunaga. Training-induced changes in muscle architecture and specific tension. Eur. J. Appl. Physiol. 72:37-43. 1995.
47. Klitgaard, H., M. Zhou, and E.A. Richter. Myosin heavy chain composition of single fibers from m. biceps brachii of male body builders. Acta Physiol. Scand. 140:175-180. 1990.
48. Kraemer, W.J., S.J. Fleck, J.E. Dziados, E.A. Harman, L.J. Marchitelli, S.E. Gordon, R. Mello, P.N. Frykman, L.P. Ko-ziris, and N.T. Triplett. Changes in hormonal concentrations following different heavy resistance exercise protocols in women. J. Appl. Physiol. 75:594-604. 1993.
49. Kraemer, WJ., S.J. Fleck, and WJ. Evans. Strength and power training: Physiological mechanisms of adaptation. Exerc. Sport Sci. Rev. 24:363-398. 1996.
50. Kraemer, W.J., A.C. Fry, B.J. Warren, M.H. Stone, S.J. Fleck, J.T. Kearney, B.P. Conroy, C.M. Maresh, C.A. Weseman, N.T. Triplett, and S.E. Gordon. Acute hormonal responses in elite junior weightlifters. Int. J. Sports Med. 13:103-109. 1992.
51. Kraemer, WJ., S.E. Gordon, S.J. Fleck, L.J. Marchitelli, R. Mello, J.E. Dziados, K. Friedl, E. Harman, C. Maresh, and A.C. Fry. Endogenous anabolic hormonal and growth factor responses to heavy resistance exercises in males and females. Int. J. Sports Med. 12:228-235. 1991.
52. Kraemer, W.J., K. Hakkinen, R.U. Newton, M. McCormick, B.C. Nindl, J.S. Volek, L.A. Gotshalk, S.J. Fleck, W.W. Cambell, S.E. Gordon, P.A. Farrell, and WJ. Evans. Acute hormonal responses to heavy resistance exercise in younger and older men. Eur. J. Appl. Physiol. 77:206-211. 1998.
53. Kraemer, WJ., L. Marchitelli, S.E. Gordon, E. Harman, J.E. Dziados, R. Mello, P. Frykman, D. McCurry, and S.J. Fleck. Hormonal and growth factor responses to heavy resistance exercise protocols. J. Appl. Physiol. 69:1442-1450. 1990.
54. Lee, R.G., P. Ashby, D.G. White, and A.J. Aguayo. Analysis of motor conduction velocity in the human median nerve by computer simulation of compound muscle action potentials. Electroenceph. Clin. Neurophysiol. 39:225-237. 1975.
55. Lexell, J., K. Henriksson-Larsen, and M. Sjostrom. Distribution of different fiber types in human skeletal muscles. 2. A study of cross-sections of whole m. vastus lateralis. Acta Physiol. Scand. 117:115-122. 1983.
56. Lindman, R., A. Eriksson, and L.-E. Thornell. Fiber type composition of the human male trapezius muscle: Enzyme-histochemical characteristics. Am. J. Anat. 189:236-244. 1990.
57. Lindman, R., A. Eriksson, and L.-E. Thornell. Fiber type composition of the human female trapezius muscle: Enzyme-histochemical characteristics. Am. J. Anat. 190:385-392. 1991.
58. Lipetz, S., and B. Gutin. An electromyographic study of four abdominal exercises. Med. Sci. Sports 2:35-38. 1970.
59. Lutoslawska, G., Z. Obminski, A. Krogulski, and W. Sendecki. Plasma cortisol and testosterone following 19-km and 42-km kayak races. J. Sports Med. Phys. Fit. 31:538-542. 1991.
60. MacDougall, J.D. Morphological changes in human skeletal muscle following strength training and immobilization. in: Human Muscle Power. N.L. Jones, N. McCartney, and A.J. McComas, eds. Champaign, IL: Human Kinetics, 1986. pp. 269-288.
61. MacDougall, J.D., G.C.B. Elder, D.G. Sale, J.R. Moroz, and J.R. Sutton. Effects of strength training and immobilization on human muscle fibers. Eur. J. Appl. Physiol. 43:25-34. 1980.
62. MacDougall, J.D., D.G. Sale, S.E. Alway, and J.R. Sutton. Muscle ultrastructural characteristics of elite powerlifters and bodybuilders. Eur. J. Appl. Physiol. 48:117-126. 1982.
63. MacDougall, J.D., D.G. Sale, S.E. Alway, and J.R. Sutton. Muscle fiber number in biceps brachii in bodybuilders and control subjects. J. Appl. Physiol. 57:1399-1403. 1984.
64. MacDougall, J.D., D.G. Sale, J.R. Moroz, E.C.B. Elder, and J.R. Sutton. Mitochondrial volume density in human skeletal muscle following heavy resistance training. Med. Sci. Sports Ex-erc. 11:164-166. 1979.
65. MacDougall, J.D., G.R. Ward, D.G. Sale, and J.R. Sutton. Biochemical adaptation of human skeletal muscle to heavy resistance training and immobilization. J. Appl. Physiol. 43:700-703. 1977.
66. Manta, P., N. Kalfak, E. Kararizou, D. Vassilopoulos, and C. Papageorgiou. Size and proportion of fiber types in human muscle fascicles. Clin. Neuropathol. 15:116-118. 1996.
67. Mayhew, T.P., J.M. Rothstein, S.D. Finucane, and R.L. Lamb. Muscular adaptation to concentric and eccentric exercise at equal power levels. Med. Sci. Sports Exerc. 27:868-873. 1995.
68. McCall, G.E., D.L. Allen, J.K. Linderman, R.E. Grindeland, R.R. Roy, V.R. Mukku, and VR. Edgerton. Maintenance of myonuclear domain size in rat soleus after overload and growth hormone/IGF-1 treatment. J. Appl. Physiol. 84:1407-1412. 1998.
69. McCall, G.E., W.C. Byrnes, A. Dickinson, P.M. Pattany, and S.J. Fleck. Muscle fiber hypertrophy, hyperplasia, and capillary density in college men after resistance training. J. Appl. Physiol. 81:2004-2012. 1996.
70. McCall, G.E., C. Goulet, R.E. Grindeland, J.A. Hodgson, A.J. Bigbee, and V.R. Edgerton. Bed rest suppresses bioassay-able growth hormone release in response to muscle activity. J. Appl. Physiol. 83:2086-2090. 1997.
71. McCaw, S.T., and J.J. Friday. A comparison of muscle activity between a free weight and machine bench press. J. Strength Cond. Res. 8:259-264. 1994.
72. McComas, A.J. Motor units. In: Skeletal Muscle-Form and Function. Champaign, IL: Human Kinetcs, 1996. pp.183-203.
73. Moss, B.M., P.E. Renes, A. Abildgaard, K. Nicolaysen, and J. Jensen. Effects of maximal effort strength training with different loads on dynamic strength, cross-sectional area, loadpower and load-velocity relationships. Eur. J. Appl. Physiol. 75: 193-199. 1997.
74. Nardone, A., C. Romano, and M. Schieppati. Selective recruitments of high-threshold human motor units during voluntary isotonic-lengthening of active muscles. J. Physiol. 409: 451-471. 1989.
75. Narici, M.V, H. Hoppeler, B. Kayser, L. Landoni, H. Claas-sen, C. Gavardi, M. Conti, and P. Cerretelli. Human quadriceps cross-sectional area, torque, and neural activation during 6 months of strength training. Acta Physiol. Scand. 157:175-186. 1996.
76. Narici, M.V, and B. Kayser. Hypertrophic response of human skeletal muscle to strength training in hypoxia and nor-moxia. Eur. J. Appl. Physiol. 70:213-219. 1995.
77. Narici, M.V., G.S. Roi, L. Landoni, A.E. Minetti, and P. Cerretelli. Changes in force, cross-sectional area and neural activation during strength training and detraining of the human quadriceps. Eur. J. Appl. Physiol. 59:310-319. 1989.
78. Nygaard, E., H. Nielsen, and B. Saltin. Number of muscle fibers in human muscle determined in vivo. Acta Physiol. Scand. Suppl. 473:37. 1979.
79. O’Connell, J. Volcanic peaks. Muscle Fit. 59:58-65. 1998.
80. Pernus, F., and I. Erzen. Arrangement of fiber types within fascicles of human vastus lateralis muscle. Muscle Nerve 14:304-309. 1991.
81. Peter, J.B., R.J. Barnard, V.R. Edgerton, C.A. Gillespie, and K.E. Stempel. Metabolic profiles of three fiber types of skeletal muscle in guinea pigs and rabbits. Biochemistry 11:2627-2633. 1972.
82. Prince, F.P., R.S. Hikida, and F.C. Hagerman. Human muscle fiber types in powerlifters, distance runners, and untrained subjects. Pflugers Arch. 363:19-26. 1976.
83. Punkt, K., H. Mehlhorn, and H. Hilbig. Region-and age-dependent variations of muscle fiber properties. Acta Histochem. 100:37-58. 1998.
84. Reichmann, H., and D. Pette. A comparative microphotometric study of succinic dehydrogenase activity levels in type I, IIA, and IIB fibers of mammalian and human muscles. Histochemistry 74:27-41. 1982.
85. Roman, W.J., J. Fleckenstein, J. Stray-Gundersen, S.E. Alway, R. Peshock, and W.J. Gonyea. Adaptations in the elbow flexors of elderly males after heavy resistance training. J. Appl. Physiol. 74:750-754. 1993.
86. Sakuma, K., A. Yamaguchi, and S. Katsuta. Are region-specific changes in fibre types attributable to nonuniform muscle hypertrophy by overloading? Eur. J. Appl. Physiol. 71:499-504. 1995.
87. Sarti, M.A., M. Monfort, M.A. Fuster, and L.A. Villa-plana. Muscle activity in upper and lower rectus abdominus during abdominal exercises. Arch. Phys. Med. Rehabil. 77:1293-1297. 1996.
88. Signorile, J.F., D. Kacsik, A. Perry, B. Robertson, R. Williams, I. Lowensteyn, S. Digel, J. Caruso, and W.G. LeBlanc. Effect of foot position on the electromyographical activity of the superficial quadriceps muscles during the parallel squat and knee extension. J. Strength Cond. Res. 9:182-187. 1995.
89. Sjostrom, M., D.Y. Downham, and J. Lexell. Distribution of different fiber types in human skeletal muscles: Why is there a difference within a fascicle? Muscle Nerve 9:30-36. 1986.
90. Sola, O.M., L.C. Haines, B.A. Kakulas, T. Ivey, D.H. Dillard, R. Thomas, Y. Shoji, Y. Fujimura, and L. Dahm. Comparative anatomy and histochemistry of human and canine latissimus dorsi muscle. J. Heart Transplant. 9:151-159. 1990.
91. Sola, O.M., S. Herring, G. Zhang, X. Huang, N. Hayashida, L.C. Haines, R. Thomas, B.A. Kakulas, and L.R. Sauvage. Significance of the biopsy site of the latissimus dorsi muscle for fiber typing. J. Heart Transplant. 11:S315-S319. 1992.
92. Staron, R.S. Human skeletal muscle fiber types: Delineation, development, and distribution. Can. J. Appl. Physiol. 22:307-327. 1997.
93. Staron, R.S., and P. Johnson. Myosin polymorphism and differential expression in adult human skeletal muscle. Comp. Bio-chem. Physiol. 106B:463-475. 1993.
94. Staron, R.S., D.L. Karapondo, W.J. Kraemer, A.C. Fry, S.E. Gordon, J.E. Falkel, F.C. Hagerman, and R.S. Hikida. J. Appl. Physiol. 76:1247-1255. 1994.
95. Staron, R.S., M.J. Leonardi, D.L. Karapondo, E.S. Malicky, J.E. Falkel, F.C. Hagerman, and R.S. Hikida. Strength and skeletal muscle adaptations in heavy-resistance-trained women after detraining and retraining. J. Appl. Physiol. 70:631-640. 1991.
96. Staron, R.S., E.S. Malicky, M.J. Leonardi, J.E. Falkel, F.C. Hagerman, and G.A. Dudley. Muscle hypertrophy and fast fiber type conversions in heavy resistance trained women. Eur. J. Appl. Physiol. 60:71-79. 1990.
97. Tesch, P.A. Short-and long-term histochemical and biochemical adaptations in muscle. In: Strength and Power in Sports. P. Komi, ed. Oxford: Blackwell, 1992. pp. 239-248.
98. Tesch, P.A., E.B. Colliander, and P. Kaiser. Muscle metabolism during intense, heavy-resistance exercise. Eur. J. Appl. Physiol. 55:362-366. 1986.
99. Tesch, PA., and L. Larsson. Muscle hypertrophy in bodybuilders. Eur. J. Appl. Physiol. 49:301-306. 1982.
100. Tesch, PA., and S. Lindeberg. Blood lactate accumulation during arm exercise in world class paddlers and strength trained athletes. Eur. J. Appl. Physiol. 52:441-445. 1984.
101. Tesch, PA., L.L. Ploutz-Snyder, L. Ystrom, M.J. Castro, and G.A. Dudley. Skeletal muscle glycogen loss evoked by resistance exercise. J. Strength Cond. Res. 12:67-73. 1998.
102. Tesch, P.A., A. Thorsson, and E.B. Colliander. Effects of eccentric and concentric resistance training on skeletal muscle substrates, enzyme activities and capillary supply. Acta. Physiol. Scand. 140:575-580. 1990.
103. Tesch, P.A., A. Thorsson, and B. Essen-Gustavsson. Enzyme activities of FT and ST muscle fibers in heavy-resistance trained athletes. J. Appl. Physiol. 67:83-87. 1989.
104. Thorstensson, A., and H. Carlson. Fibre types in human lumbar back muscles. Acta Physiol. Scand. 131:195-202. 1987.
105. Tseng, B.S., C.E. Kasper, and V.R. Edgerton. Cytoplasm-to-myonucleus ratios and succinate dehydrogenase activities in adult rat slow and fast muscle fibers. Cell Tissue Res. 275:39 49. 1994.
106. Webb, M.L., J.P Wallace, C. Hamill, J.L. Hodgson, and M.M. MASHALY. Serum testosterone concentration during two hours of moderate intensity treadmill running in trained men and women. Endocr. Res. 10:27-38. 1984.
107. Wickiewicz, T.L., R.R. Roy, PL. Powell, and V.R. Edgerton. Muscle architecture of the human lower limb. Clin. Orthop. Related Res. 179:275-283. 1983.