HLA-DRB1 alleles and rheumatoid arthritis in Northern Italy: Lack of correlation with disease severity and extra-articular manifestations;Alleli HLA-DRB1 e artrite reumatoide nel nord Italia: Assenza di correlazione con la gravità della malattia e con manifestazioni extra-articolari

Recenti Progressi in Medicina

Volumn 96, Issue 3, 2005, Pages 139-143

  Beri, Ruggero ^a   Peterlana, Dimitri ^a   Puccetti, Antonio ^b   Simeoni, Sara ^a   Garzotti, Paolo ^c   Biasi, Domenico ^a   Caramaschi, Paola ^a   Tinazzi, Elisa ^a   Lunardi, Claudio ^a,d  

^a UNIVERSITY OF VERONA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c MAGGIORE HOSPITAL   (Italy)

^d Clinica di Medicina Interna D   (Italy)

Author keywords

Extra articular disease; HLA DRB1 alleles; Rheumatoid arthritis

Indexed keywords

EPITOPE; HLA DR ANTIGEN;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; GENE FREQUENCY; HUMAN; HYBRIDIZATION; ITALY; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS;

ALLELES; ARTHRITIS, RHEUMATOID; FEMALE; HLA-DR ANTIGENS; HUMANS; ITALY; MALE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX;

EID: 22844450190     PISSN: 00341193     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Nepom GT, Erlich H. MHC class-II and autoimmunity. Ann Rev Immunol 1991; 9: 493-523.
2. Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987; 30: 1205-13.
3. Yen J, Chen J, Tsai W, Tsai J, Liu H. HLA-DRB1 genotyping in patients with rheumatoid arthritis in Taiwan. J Rheumatol 1995; 22: 1450-4.
4. Tan PL, Farmiloe S, Roberts M, Geursen A, Skinner MA. HLA-DR4 subtypes in New Zealand Polynesians. Predominance of Dw13 in the healthy population association of Dw15 with rheumatoid arthritis. Arthritis Rheum 1993; 36: 15-9.
5. Weyand CA, Hicok KC, Conn DL, Goronzy J: The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis. Ann Intern Med 1992; 117:801-806.
6. Weyand CA, Xie C, Goronzy JJ: Homozygosity for the HLA-DRB1 allele selects for extraarticular manifestation in rheumatoid arthritis. J Clin Invest 1992; 89:2033-7.
7. Drosos AA, Lanchbury JS, Panayi GS, Moutsopoulos HM. Rheumatoid arhtritis in Greek and British patients. Arthritis Rheum 1992; 35: 745-8.
8. Benazet JF, Reviron D, Mercier P, Roux H, Roudier J. HLA-DRB1 alleles associated with rheumatoid arthritis in Southern France. Absence of extraarticular disease despite expression of the shared epitope. J Rheumatol 1995; 22: 607-10.
9. Angelini G, Morozzi G, Delfino L, Falco M, et al. Analysis of HLA DP, DQ and DR alleles in adult Italian rheumatoid arthritis patients. Hum Immunol 1992; 34: 135-41.
10. Salvarani C, Macchioni PL, Mantovani W, et al. Extra articular manifestations of rheumatoid arthritis and HLA antigens in Northern Italy. J Rheumatol 1992; 19: 242-6.
11. Salvarani C, Macchioni PL, Mantovani W, et al. HLA-DRB1 alleles associated with rheumatoid arthritis in Northern Italy: correlation with disease severity. Br J Rheumatol 1998; 37: 165-9.
12. Arnett F, Edworthy S, Blooch D, et al.: The American Rheumatism Association 1987 revisited criteria for the classification of rheumatoid arthitis. Arthritis Rheum 1988; 31: 351-24.
13. Buckner JH, Nepom GT. Genetics of rheumatoid arthritis: is there a scientific explanation for the human leukocyte antigen association? Curr Opin Rheumatol 2002; 14: 254-9.
14. McDaniel O, Alarcon G, Parks W, Reveille J. Most African-American patients with rheumatoid arthritis do not have the rheumatoid antigenic determinant epitope. Ann Intern Med 1995; 123: 181-7.
15. Weyand CM, McCarthy TG, Goronzy JJ. Correlation between disease phenotype and genetic heterogeneity in rheumatoid arthritis. J Clin Invest 1995; 95: 2120-6.
16. Zanelli E, Gonzales G, David CS. Could HLA-DRB1 be the protective locus in rheumatoid arthritis? Immunology Today 1995; 16: 274-8.
17. De Vries N, Tijssen H, van Riel PLCM, van de Putte LBA. Reshaping the shared epitope hypothesis. Arthritis Rheum 2002; 46: 921-98.
18. Reviron D, Perdriger A, Toussirot E, et al. Influence of shared epitope-negative HLA-DRB1 alleles on genetic susceptibility to rheumatoid arthritis. Arthritis Rheum 2001; 44: 535-40.
19. Pascual M, Nieto A, Lopez-Nevot MA, et al. Rheumatoid arthritis in Southern Spain: toward elucidation of a unifying role of the HLA class II region in disease predisposition. Arthritis Rheum 2001; 44: 307-14
20. Higami K, Hakoda M, Matsuda Y, Ueda H, Kashiwazaky S. Lack of association of HLA-DRB. Genotype with radiological progression in Japanese patients with early rheumatoid arthritis. Arthritis Rheum 1997; 12: 2241-7.
21. Reveille J. The genetic contribution to the pathogenesis of rheumatoid arthritis. Cur Opin Rheumatol 1998; 10: 187-200.
22. Lard LR, Boers M, Verhoeven, et al. Early and aggressive treatment of rheumatoid arthritis patients affects the association of HLA class II with progression of joint damage. Arthritis Rheum 2002; 46: 899-905.