Quantitative measurement of fibrillogenesis by mass spectrometry

Methods in Molecular Biology

Volumn 299, Issue , 2005, Pages 185-194

  Miranker, Andrew D ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

Amylin; Amyloid; Electrospray; Fibrillogenesis; IAPP; 2microglobulin mass spectrometry

Indexed keywords

AMYLOID;

ANALYTIC METHOD; CONCENTRATION (PARAMETERS); ELECTROSPRAY MASS SPECTROMETRY; FIBRILLOGENESIS; HUMAN; MASS SPECTROMETRY; MEASUREMENT; NONHUMAN; PROTEIN PROCESSING; PROTEIN STABILITY; QUANTITATIVE ANALYSIS; SEPARATION TECHNIQUE;

EID: 22844441847     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1385/1-59259-874-9:185     Document Type: Chapter

References (16)

1. Kelly, J. W. (1998) The alternative conformations of amyloidogenic proteins and their multistep assembly pathways. Curr. Opin. Struct. Biol. 8, 101-106.
2. Rochet, J. C. and Lansbury, P. T. Jr. (2000) Amyloid fibrillogenesis: themes and variations. Curr. Opin. Struct. Biol. 10, 60-68.
3. Larson, J. L., Ko, E., and Miranker, A. D. (2000) Direct measurement of islet amyloid polypeptide fibrillogenesis by mass spectrometry. Protein Sci. 9, 427-431.
4. Hoppener, J. W. M., Ahren, B., and Lips, C. J. M. (2000) Islet amyloid and type 2 diabetes mellitus. N. Engl. J. Med. 343, 411-419.
5. Jaikaran, E. T. and Clark, A. (2001) Islet amyloid and type 2 diabetes: from molecular misfolding to islet pathophysiology. Biochim. Biophys. Acta 1537, 179-203.
6. Hooke, S. D., Eyles, S. J., Miranker, A., Radford, S. E., Robinson, C. V., and Dobson, C. M. (1995) Cooperative elements in protein-folding monitored by electrosprayionization mass-spectrometry. J. Am. Chem. Soc. 117, 7548-7549.
7. Canet, D., Last, A. M., Tito, P., et al. (2002) Local cooperativity in the unfolding of an amyloidogenic variant of human lysozyme. Nat. Struct. Biol. 9, 308-315.
8. Eakin, C. M., Knight, J. D., Morgan, C. J., Gelfand, M. A., and Miranker, A. D. (2002) Formation of a copper specific binding site in non-native states of beta-2-microglobulin. Biochemistry 41, 10646-10656.
9. Oda, Y., Huang, K., Cross, F. R., Cowburn, D., and Chait, B. T. (1999) Accurate quantitation of protein expression and site-specific phosphorylation. Proc. Natl. Acad. Sci. USA 96, 6591-6596.
10. Gygi, S. P., Rist, B., Gerber, S. A., Turecek, F., Gelb, M. H., and Aebersold, R. (1999) Quantitative analysis of complex protein mixtures using isotope-coded affinity tags. Nat. Biotechnol. 17, 994-999.
11. LeVine, H. D. (1993) Thioflavine T interaction with synthetic Alzheimer’s disease betaamyloid peptides: detection of amyloid aggregation in solution. Protein Sci. 2, 404-410.
12. Padrick, S. B. and Miranker, A. D. (2002) Islet amyloid: phase partitioning and secondary nucleation are central to the mechanism of fibrillogenesis. Biochemistry 41, 4694-4703.
13. Kebarle, P. (2000) A brief overview of the present status of the mechanisms involved in electrospray mass spectrometry. J. Mass Spectrom 35, 804-817.
14. Cole, R. B. (2000) Some tenets pertaining to electrospray ionization mass spectrometry. J. Mass Spectrom 35, 763-772.
15. Westermark, P., Engstrom, U., Johnson, K. H., Westermark, G. T., and Betsholtz, C. (1990) Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation. Proc. Natl. Acad. Sci. USA 87, 5036-5040.
16. Larson, J. L. and Miranker, A. D. (2004) The mechanism of insulin action on islet amyloid polypeptide fiber formation. J. Mol. Biol. 35, 221-231.