Effect of cysteamine on bile secretion in the rat

Pharmacological Reports

Volumn 57, Issue 3, 2005, Pages 345-351

  Abdel Salam, Omar M E ^a   Baiuomy, Ayman R ^a   El Shenawy, Siham M ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Bile secretion; Cysteamine; Rat; Somatostatin

Indexed keywords

ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; GLUCOSE; LIPID; LIVER ENZYME; MERCAPTAMINE; URETHAN;

ANIMAL EXPERIMENT; ARTICLE; BILE DUCT; BILE SECRETION; CHOLESTEROL BILE LEVEL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; LIPID BILE LEVEL; LIPOGENESIS; MALE; NONHUMAN; PROTEIN SECRETION; RAT;

EID: 22744456235     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Ahren B, Bottcher G, Ekman R, Sundler F: Cysteamine and the endocrine pancreas: immunocytochemical, immunochemical, and functional aspects. Cell Tissue Res, 1989, 256, 159-166.
2. Arrese M, Pizarro M, Solis N, Koenig C, Accatino L: Enhanced biliary excretion of canalicular membrane enzymes in ethynylestradiol-induced cholestasis. Effects of ursodeoxycholic acid administration. Biochem Pharmacol, 1995, 50, 1223-1232.
3. Bauer JD: Clinical Laboratory Methods, 9th edn., C.V. Mosby Company, St. Louis, Toronto, London, 1982.
4. Bergstrom K, Thulin L: Effects of somatostatin on hepatic bile formation. Gastroenterology, 1989, 96, 206-212.
5. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem, 1976, 72, 248-254.
6. Burwen SJ, Schmucker DL, Jones A: Subcellular and molecular mechanisms of bile secretion. Int Rev Cytol, 1992, 135, 269-313.
7. Del-Puppo M, Paroni R, Galli-Kienle M: Modulation of HMG-CoA reductase activity by pantetheine/pantethine. Biochim Biophys Acta, 1988, 963, 389-393.
8. Farouk M, Geoghegan JG, Pruthi RS, Thomson HJ, Pappas TN, Meyers WC: Intracerebroventricular neuropeptide Y stimulates bile secretion via a vagal mechanism. Gut, 1992, 33, 1562-1565.
9. Fernandez G, Villarruel MC, Castro JA: Effect of cystamine on protein, phospholipid and RNA synthesis or degradation. Res Commun Chem Pathol Pharmacol, 1984, 43, 511-514.
10. Gahl WA, Bercu BB: Blunted prolactin response to thyrotropin-releasing hormone stimulation in cystinotic children receiving cysteamine. J Clin Endocrinol Metab, 1985, 60, 793-796.
11. Gahl WA, Charnas L, Markello TC, Bernardini I, Ishak KG, Dalakas MC: Parenchymal organ cystine depletion with long-term cysteamine therapy. Biochem Med Metab Biol, 1992, 48, 275-285.
12. Gullo L, Priori P, Scarpignato C, Baldoni F, Mattioli G, Barbara L: Effect of somatostatin 14 on pure human pancreatic secretion. Dig Dis Sci, 1987, 32, 1065-1070.
13. Gyr KE, Meier R: Pharmacodynamic effects of Sandostatin in the gastrointestinal tract. Digestion, 1993, 54, Suppl 1, 14-19.
14. Kanz MF, Gunasena GH, Kaphalia L, Hammond DK, Syed YA: A minimally toxic dose of methylene dianiline injures biliary epithelial cells in rats. Toxicol Appl Pharmacol, 1988, 150, 414-425.
15. Matturri L, Galbussera M, Lovati MR, Franceschini G, Sirtori CR: Pantethine reduces plasma cholesterol and the severity of arterial lesions in experimental hypercholesterolemic rabbits. Atherosclerosis, 1984, 53, 255-264.
16. McCarty MF: Inhibition of acetyl-CoA carboxylase by cystamine may mediate the hypotriglyceridemic activity of pantethine. Med Hypotheses, 2001, 56, 314-317.
17. McIntosh CH, Bakich V, Bokenfohr K, DiScala-Guenot D, Kwok YN, Brown JC: Cysteamine-induced reduction in gastrointestinal somatostatin, evidence for a region-specific loss in immunoreactivity. Regul Pept, 1988, 21, 205-218.
18. Nyberg B: Bile secretion in man. The effects of somatostatin, vasoactive intestinal peptide and secretin. Acta Chir Scand Suppl, 1990, 557, 1-40.
19. Prescott LF, Sutherland GR, Park J, Smith IJ, Proudfoot AT: Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. Lancet, 1976, 2, 109-113.
20. Prisco D, Rogasi PG, Matucci M, Paniccia R, Abbate R, Gensini GF, Neri-Serneri GG: Effect of oral treatment with pantethine on platelet and plasma phospholipids in IIa hyperlipoproteinemia. Angiology, 1987, 38, 241-217.
21. Reichlin S, Bollinger-Gruber JA: Pantethine, a cysteamine precursor, depletes immunoreactive somatostatin and prolactin in the rat. Endocrinology, 1985, 117, 492-495.
22. Schonfeld JV, Muller MK, Augustin M, Runzi M, Goebell H: Effect of cysteamine on insulin release and exocrine pancreatic secretion in vitro. Dig Dis Sci, 1993, 38, 28-32.
23. Shults C, Steardo L, Barone P, Mohr E, Juncos J, Serrati C, Fedio P et al.: Huntington's disease: effect of cysteamine, a somatostatin-depleting agent. Neurology, 1986, 36, 1099-1102.
24. Silvestre RA, Miralles P, Moreno P, Villanueva ML, Marco J: Somatostatin, insulin and glucagon secretion by the perfused pancreas from the cysteamine-treated rat. Biochem Biophys Res Commun, 1986, 134, 1291-1297.
25. Sorenson RL, Grouse LH, Elde RP: Cysteamine blocks somatostatin secretion without altering the course of insulin or glucagon release. A new model for the study of islet function. Diabetes, 1983, 32, 377-379.
26. Srikant CB, Patel YC: Cysteamine-induced depletion of brain somatostatin is associated with up-regulation of cerebrocortical somatostatin receptors. Endocrinology, 1984, 115, 990-995.
27. Szabo S, Reichlin S: Somatostatin in rat tissues is depleted by cysteamine administration. Endocrinology, 1981, 109, 2255-2257.
28. Vecsei L, Widerlov E: Preclinical and clinical studies with cysteamine and pantethine related to the central nervous system. Prog Neuropsychopharmacol Biol Psychiatry, 1990, 14, 835-862.
29. Wittwer CT, Gahl WA, Butler JD, Zatz M, Thoene JG: Metabolism of pantethine in cystinosis. J Clin Invest 1985, 76, 1665-1672.
30. Wittwer CT, Graves CP, Peterson MA, Jorgensen E, Wilson DE, Thoene JG, Wyse BW et al.: Pantethine lipomodulation: evidence for cysteamine mediation in vitro and in vivo. Atherosclerosis, 1987, 68, 41-49.
31. Zajac JM, Bernard P: Effects of cysteamine and of irradiation on microsomal membrane-bound enzymes. Enzyme, 1982, 28, 382-386.