Amelioration of erectile dysfunction following a switch from carbamazepine to oxcarbazepine: Recent clinical experience

Current Medical Research and Opinion

Volumn 21, Issue 7, 2005, Pages 1065-1068

  Sachdeo, Rajesh ^a,b   Sathyan, Revathi R ^a  

^a UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^b SAINT PETER S UNIVERSITY HOSPITAL   (United States)

Author keywords

Antiepileptic drugs; Carbamazepine; Epilepsy; Erectile dysfunction; Oxcarbazepine

Indexed keywords

CARBAMAZEPINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PRIMIDONE; SILDENAFIL; TESTOSTERONE;

ADULT; CASE REPORT; COMPLEX PARTIAL SEIZURE; DIPLOPIA; DISEASE SEVERITY; DIZZINESS; DRUG BLOOD LEVEL; DRUG DOSE REDUCTION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; ERECTILE DYSFUNCTION; FOCAL EPILEPSY; FOLLOW UP; GRAND MAL SEIZURE; HUMAN; HYPONATREMIA; LABORATORY TEST; LIBIDO DISORDER; MALE; MONOTHERAPY; NAUSEA; REVIEW; TESTOSTERONE BLOOD LEVEL; VISUAL IMPAIRMENT;

ANTICONVULSANTS; CARBAMAZEPINE; EPILEPSY; HUMANS; IMPOTENCE; MALE; MIDDLE AGED; PENILE ERECTION;

EID: 22744450902     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/030079905X50561     Document Type: Review

References (17)

1. Tecoma ES. Oxcarbazepine. Epilepsia 1999;40(Suppl 5):S37-S46
2. Isojarvi JI, Repo M, Pakarinen AJ, Lukkarinen O, Myllyla VV. carbamazepine, phenytoin, sex hormones, and sexual function in men with epilepsy. Epilepsia 1995;36:366-70
3. Herzog AG, Drislane FW, Schomer DL, Pennell PB, Bromfield EB, Kelly KM et al. Differential effects of antiepileptic drugs on sexual function and reproductive hormones in men with epilepsy: interim analysis of a comparison between lamotrigine and enzyme-inducing antiepileptic drugs. Epilepsia 2004;45:764-8
4. Silva HC, Carvalho MJ, Jorge CL, Cunha Neto MB, Goes PM, Yacubian EM. Sexual disorders in epilepsy. Results of a multidisciplinary evaluation [in Portuguese]. Arq Neuropsiquiatr 1999;57:798-807
5. Leris AC, Stephens J, Hines JE, McNicholas TA. carbamazepine-related ejaculatory failure. Br J Urol 1997;79:485
6. Dam M, Ekberg R, Loyning Y, Waltimo O, Jakobsen K. A double-blind study comparing oxcarbazepine and carbamazepine in patients with newly diagnosed, previously untreated epilepsy. Epilepsy Res 1989;3:70-6
7. Reinikainen KJ, Keranen T, Halonen T, Komulainen H, Riekkinen PJ. Comparison of oxcarbazepine and carbamazepine: a double-blind study. Epilepsy Res 1987;1:284-9
8. Rättyä J, Turkka J, Pakarinen AJ, Knip M, Kotila MA, Lukkarinen O et al. Reproductive effects of valproate, carbamazepine, and oxcarbazepine in men with epilepsy. Neurology 2001;56:31-6
9. Isojarvi JI, Pakarinen AJ, Rautio A, Pelkonen O, Myllyla VV. Serum sex hormone levels after replacing carbamazepine with oxcarbazepine. Eur J Clin Pharmacol 1995;47:461-4
10. Pommerville P. Erectile dysfunction: an overview. Can J Urol 2003;10(Suppl 1):2-6
11. Lambert MV. Seizures, hormones and sexuality. Seizure 2001;10:319-40
12. Brunet M, Rodamilans M, Martinez-Osaba MJ, Santamaria J, To-Figueras J, Torra M et al. Effects of long-term antiepileptic therapy on the catabolism of testosterone. Pharmacol Toxicol 1995;76:371-5
13. Rättyä J, Pakarinen AJ, Knip M, Repo-Outakoski M, Myllyla VV, Isojarvi JI. Early hormonal changes during valproate or carbamazepine treatment: a 3-month study. Neurology 2001;57:440-4
14. Ahn HS, Park CM, Lee SW. The clinical relevance of sex hormone levels and sexual activity in the ageing male. BJU Int 2002;89:526-30
15. Aversa A, Isidori AM, De Martino MU, Caprio M, Fabbrini E, Rocchietti-March M et al. Androgens and penile erection: evidence for a direct relationship between free testosterone and cavernous vasodilation in men with erectile dysfunction. Clin Endocrinol 2000;53:517-22
16. Alexopoulou O, Jamart J, Maiter D, Hermans MP, De Hertogh R, De Nayer P et al. Erectile dysfunction and lower androgenicity in type 1 diabetic patients. Diabetes Metab 2001;27:329-36
17. Schmidt D, Elger CE. What is the evidence that oxcarbazepine and carbamazepine are distinctly different antiepileptic drugs? Epilepsy Behav 2004;5:627-35