Involvement of neutral endopeptidase in neoplastic progression

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1751, Issue 1, 2005, Pages 52-59

  Sumitomo, Makoto ^a   Shen, Ruoqian ^b   Nanus, David M ^b  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Bombesin; Cell migration; Cell survival; Endothelin 1; Neutral endopeptidase; Prostate cancer; Tumor suppressor

Indexed keywords

BOMBESIN; ENDOTHELIN 1; EZRIN; MEMBRANE METALLOENDOPEPTIDASE; MOESIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE LYN; RADIXIN; RECOMBINANT ENZYME; TUMOR SUPPRESSOR PROTEIN;

CANCER GROWTH; CANCER INHIBITION; CARCINOGENESIS; CELL LINE; CELL MIGRATION; CELL SURFACE; CELL SURVIVAL; CONFERENCE PAPER; CYTOPLASM; ENZYME ANALYSIS; ENZYME DEGRADATION; ENZYME MECHANISM; ENZYME SUBSTRATE; HUMAN; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; WILD TYPE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIGENS, CD44; APOPTOSIS; CELL MOVEMENT; ENZYME ACTIVATION; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; FOCAL ADHESIONS; HUMANS; MALE; NEOPLASM INVASIVENESS; NEPRILYSIN; NEUROFIBROMIN 2; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; TETRADECANOYLPHORBOL ACETATE; TUMOR SUPPRESSOR PROTEINS;

EID: 22744448900     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2004.11.001     Document Type: Conference Paper

References (56)

1. D.M. Nanus, R. Shen, J. Dai, and M. Sumitomo Neutral endopeptidase and other peptidases such as aminopeptidase A and dipeptidyl peptidase IV in the development and progression of cancer S. Mizutani A.J. Turner S. Nomura K. Ino Cell-Surface Aminopeptidases: Basic and Clinical Aspects 2001 Elsevier Amsterdam 119 128
2. D.M. Nanus Of peptides and peptidases: the role of cell surface peptidases in cancer Clin. Cancer Res. 9 2003 6307 6309
3. M.A. Shipp, G.E. Tarr, C.Y. Chen, S.N. Switzer, L.B. Hersh, H. Stein, M.E. Sunday, and E.L. Reinherz CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung Proc. Natl. Acad. Sci. U. S. A. 88 1991 10662 10666
4. M.A. Shipp, and A.T. Look Hematopoietic differentiation antigens that are membrane-associated enzymes: cutting is the key! Blood 82 1993 1052 1070
5. I. Sehgal, S. Powers, B. Huntley, G. Powis, M. Pittelkow, and N.J. Maihle Neurotensin is an autocrine trophic factor stimulated by androgen withdrawal in human prostate cancer Proc. Natl. Acad. Sci. U. S. A. 91 1994 4673 4677
6. A.G. Aprikian, L. Tremblay, K. Han, and S. Chevalier Bombesin stimulates the motility of human prostate-carcinoma cells through tyrosine phosphorylation of focal adhesion kinase and of integrin-associated proteins Int. J. Cancer 72 1997 498 504
7. J.B. Nelson, and M.A. Carducci Small bioactive peptides and cell surface peptidases in androgen-independent prostate cancer Cancer Investig. 18 2000 87 96
8. M. Albrecht, A. Mittler, B. Wilhelm, A. Lundwall, H. Lilja, G. Aumuller, and A. Bjartell Expression and immunolocalisation of neutral endopeptidase in prostate cancer Eur. Urol. 44 2003 415 422
9. S.J. Freedland, D.B. Seligson, A.Y. Liu, A.J. Pantuck, S.H. Paik, S. Horvath, J.A. Wieder, A. Zisman, D. Nguyen, C.L. Tso, A.V. Palotie, and A.S. Belldegrun Loss of CD10 (neutral endopeptidase) is a frequent and early event in human prostate cancer Prostate 55 2003 71 80
10. C.N. Papandreou, B. Usmani, Y. Geng, T. Bogenrieder, R. Freeman, S. Wilk, C.L. Finstad, V.E. Reuter, C.T. Powell, D. Scheinberg, C. Magill, H.I. Scher, A.P. Albino, and D.M. Nanus Neutral endopeptidase 24.11 loss in metastatic human prostate cancer contributes to androgen-independent progression Nat. Med. 4 1998 50 57
11. R.K. Ganju, R.G. Shpektor, D.G. Brenner, and M.A. Shipp CD10/neutral endopeptidase 24.11 is phosphorylated by casein kinase II and coassociates with other phosphoproteins including the lyn src-related kinase Blood 88 1996 4159 4165
12. P. Angelisova, K. Drbal, V. Horejsi, and J. Cerny Association of CD10/neutral endopeptidase 24.11 with membrane microdomains rich in glycosylphosphatidylinositol-anchored proteins and Lyn kinase [letter] Blood 93 1999 1437 1439
13. G. Cutrona, N. Leanza, M. Ulivi, G. Melioli, V.L. Burgio, G. Mazzarello, G. Gabutti, S. Roncella, and M. Ferrarini Expression of CD10 by human T cells that undergo apoptosis both in vitro and in vivo Blood 94 1999 3067 3076
14. N.K. Harrison, K.E. Dawes, O.J. Kwon, P.J. Barnes, G.J. Laurent, and K.F. Chung Effects of neuropeptides on human lung fibroblast proliferation and chemotaxis Am. J. Physiol. 268 1995 L278 L283
15. P. Hofman, E. Selva, G. Le Negrate, L. d'Andrea, S. Guerin, B. Rossi, and P. Auberger CD10 inhibitors increase f-Met-Leu-Phe-induced neutrophil transmigration J. Leukoc. Biol. 63 1998 312 320
16. M. Sumitomo, R. Shen, M. Walburg, J. Dai, Y. Geng, D. Navarro, G. Boileau, C.N. Papandreou, F.G. Giancotti, B. Knudsen, and D.M. Nanus Neutral endopeptidase inhibits prostate cancer cell migration by blocking focal adhesion kinase signaling J. Clin. Invest. 106 2000 1399 1407
17. D.Q. Zheng, A.S. Woodard, M. Fornaro, G. Tallini, and L.R. Languino Prostatic carcinoma cell migration via alpha(v)beta3 integrin is modulated by a focal adhesion kinase pathway Cancer Res. 59 1999 1655 1664
18. I. Zachary, J. Sinnett-Smith, and E. Rozengurt Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate J. Biol. Chem. 267 1992 19031 19034
19. E.P. Salazar, and E. Rozengurt Bombesin and platelet-derived growth factor induce association of endogenous focal adhesion kinase with Src in intact Swiss 3T3 cells J. Biol. Chem. 274 1999 28371 28378
20. D.D. Schlaepfer, S.K. Hanks, T. Hunter, and P. van der Geer Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase Nature 372 1994 786 791
21. M.D. Schaller, J.D. Hildebrand, and J.T. Parsons Complex formation with focal adhesion kinase: a mechanism to regulate activity and subcellular localization of Src kinases Mol. Biol. Cell 10 1999 3489 3505
22. E. Rozengurt Signal transduction pathways in the mitogenic response to G protein-coupled neuropeptide receptor agonists J. Cell. Physiol. 177 1998 507 517
23. H.R. Reiske, S.C. Kao, L.A. Cary, J.L. Guan, J.F. Lai, and H.C. Chen Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration J. Biol. Chem. 274 1999 12361 12366
24. W. Nagel, L. Zeitlmann, P. Schilcher, C. Geiger, J. Kolanus, and W. Kolanus Phosphoinositide 3-OH kinase activates the beta2 integrin adhesion pathway and induces membrane recruitment of cytohesin-1 J. Biol. Chem. 273 1998 14853 14861
25. M.A. Adelsman, J.B. McCarthy, and Y. Shimizu Stimulation of beta1-integrin function by epidermal growth factor and heregulin-beta has distinct requirements for erbB2 but a similar dependence on phosphoinositide 3-OH kinase Mol. Biol. Cell 10 1999 2861 2878
26. A.B. Satterthwaite, C.A. Lowell, W.N. Khan, P. Sideras, F.W. Alt, and O.N. Witte Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways J. Exp. Med. 188 1998 833 844
27. A. Craxton, A. Jiang, T. Kurosaki, and E.A. Clark Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt J. Biol. Chem. 274 1999 30644 30650
28. S. Yonemura, M. Hirao, Y. Doi, N. Takahashi, T. Kondo, and S. Tsukita Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2 J. Cell Biol. 140 1998 885 895
29. S. Louvet-Vallee ERM proteins: from cellular architecture to cell signaling Biol. Cell 92 2000 305 316
30. A. Iwase, R. Shen, D. Navarro, and D.M. Nanus Direct binding of neutral endopeptidase 24.11 to ezrin/radixin/moesin (ERM) proteins competes with the interaction of CD44 with ERM proteins J. Biol. Chem. 279 2004 11898 11905
31. V. Stambolic, A. Suzuki, J.L. de la Pompa, G.M. Brothers, C. Mirtsos, T. Sasaki, J. Ruland, J.M. Penninger, D.P. Siderovski, and T.W. Mak Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN Cell 95 1998 29 39
32. J.P. Carson, G. Kulik, and M.J. Weber Antiapoptotic signaling in LNCaP prostate cancer cells: a survival signaling pathway independent of phosphatidylinositol 3′-kinase and Akt/protein kinase B Cancer Res. 59 1999 1449 1453
33. L.C. Cantley The phosphoinositide 3-kinase pathway Science 296 2002 1655 1657
34. T.F. Franke, C.P. Hornik, L. Segev, G.A. Shostak, and C. Sugimoto PI3K/Akt and apoptosis: size matters Oncogene 22 2003 8983 8998
35. G.N. Rao, P. Delafontaine, and M.S. Runge Thrombin stimulates phosphorylation of insulin-like growth factor-1 receptor, insulin receptor substrate-1, and phospholipase C-gamma 1 in rat aortic smooth muscle cells J. Biol. Chem. 270 1995 27871 27875
36. J. Du, L.S. Sperling, M.B. Marrero, L. Phillips, and P. Delafontaine G-protein and tyrosine kinase receptor cross-talk in rat aortic smooth muscle cells: thrombin- and angiotensin II-induced tyrosine phosphorylation of insulin receptor substrate-1 and insulin-like growth factor 1 receptor Biochem. Biophys. Res. Commun. 218 1996 934 939
37. M. Foschi, S. Chari, M.J. Dunn, and A. Sorokin Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinase EMBO J. 16 1997 6439 6451
38. T. Sasaki, J. Irie-Sasaki, R.G. Jones, A.J. Oliveira-dos-Santos, W.L. Stanford, B. Bolon, A. Wakeham, A. Itie, D. Bouchard, I. Kozieradzki, N. Joza, T.W. Mak, P.S. Ohashi, A. Suzuki, and J.M. Penninger Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration [see comments] Science 287 2000 1040 1046
39. M. Sumitomo, M.I. Milowsky, R. Shen, D. Navarro, J. Dai, T. Asano, M. Hayakawa, and D.M. Nanus Neutral endopeptidase inhibits neuropeptide-mediated transactivation of the insulin-like growth factor receptor-akt cell survival pathway Cancer Res. 61 2001 3294 3298
40. J.O. Lee, H. Yang, M.M. Georgescu, A. Di Cristofano, T. Maehama, Y. Shi, J.E. Dixon, P. Pandolfi, and N.P. Pavletich Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association Cell 99 1999 323 334
41. M.M. Georgescu, K.H. Kirsch, T. Akagi, T. Shishido, and H. Hanafusa The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region Proc. Natl. Acad. Sci. U. S. A. 96 1999 10182 10187
42. F. Vazquez, S. Ramaswamy, N. Nakamura, and W.R. Sellers Phosphorylation of the PTEN tail regulates protein stability and function Mol. Cell. Biol. 20 2000 5010 5018
43. T. Maehama, and J.E. Dixon The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate J. Biol. Chem. 273 1998 13375 13378
44. P. Cairns, K. Okami, S. Halachmi, N. Halachmi, M. Esteller, J.G. Herman, J. Jen, W.B. Isaacs, G.S. Bova, and D. Sidransky Frequent inactivation of PTEN/MMAC1 in primary prostate cancer Cancer Res. 57 1997 4997 5000
45. J. Li, C. Yen, D. Liaw, K. Podsypanina, S. Bose, S.I. Wang, J. Puc, C. Miliaresis, L. Rodgers, R. McCombie, S.H. Bigner, B.C. Giovanella, M. Ittmann, B. Tycko, H. Hibshoosh, M.H. Wigler, and R. Parsons PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer [see comments] Science 275 1997 1943 1947
46. P.A. Steck, M.A. Pershouse, S.A. Jasser, W.K. Yung, H. Lin, A.H. Ligon, L.A. Langford, M.L. Baumgard, T. Hattier, T. Davis, C. Frye, R. Hu, B. Swedlund, D.H. Teng, and S.V. Tavtigian Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers Nat. Genet. 15 1997 356 362
47. H. Tashiro, M.S. Blazes, R. Wu, K.R. Cho, S. Bose, S.I. Wang, J. Li, R. Parsons, and L.H. Ellenson Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies Cancer Res. 57 1997 3935 3940
48. D. Haas-Kogan, N. Shalev, M. Wong, G. Mills, G. Yount, and D. Stokoe Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC Curr. Biol. 8 1998 1195 1198
49. M. Sumitomo, A. Iwase, R. Zheng, D. Navarro, D. Kaminetzky, R. Shen, M.M. Georgescu, and D.M. Nanus Synergy in tumor suppression by direct interaction of neutral endopeptidase with PTEN Cancer Cell 5 2004 67 78
50. Y. Nishizuka Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C Science 258 1992 607 614
51. P.M. Blumberg Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture Cancer Res. 48 1988 1 8
52. T. Fujii, M.L. Garcia-Bermejo, J.L. Bernabo, J. Caamano, M. Ohba, T. Kuroki, L. Li, S.H. Yuspa, and M.G. Kazanietz Involvement of protein kinase C delta (PKCdelta) in phorbol ester-induced apoptosis in LNCaP prostate cancer cells. Lack of proteolytic cleavage of PKCdelta J. Biol. Chem. 275 2000 7574 7582
53. M. Sumitomo, R. Shen, J.S. Goldberg, J. Dai, D. Navarro, and D.M. Nanus Neutral endopeptidase promotes phorbol ester-induced apoptosis in prostate cancer cells by inhibiting neuropeptide-induced protein kinase C delta degradation Cancer Res. 60 2000 6590 6596
54. M.E. Reyland, S.M. Anderson, A.A. Matassa, K.A. Barzen, and D.O. Quissell Protein kinase C delta is essential for etoposide-induced apoptosis in salivary gland acinar cells J. Biol. Chem. 274 1999 19115 19123
55. A.A. Matassa, L. Carpenter, T.J. Biden, M.J. Humphries, and M.E. Reyland PKCdelta is required for mitochondrial-dependent apoptosis in salivary epithelial cells J. Biol. Chem. 276 2001 29719 29728
56. M. Sumitomo, T. Asano, J. Asakuma, D.M. Nanus, and M. Hayakawa Chemosensitization of androgen-independent prostate cancer with neutral endopeptidase Clin. Cancer Res. 10 2004 260 266