Monitoring of multiphase pharmaceutical processes using electrical resistance tomography

Chemical Engineering Research and Design

Volumn 83, Issue 7 A, 2005, Pages 794-805

  Ricard, Francois ^a   Brechtelsbauer, C ^a   Xu, X Y ^b   Lawrence, C J ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

CFD; Crystallization; Electrical resistance tomography (ERT); Multiphase mixing; Pharmaceuticals; Phase inversion; Retreat curve impeller; Stirred tank reactor

Indexed keywords

CHEMICAL REACTORS; COMPUTATIONAL FLUID DYNAMICS; DISPERSIONS; DRUG PRODUCTS PLANTS; ELECTRIC VARIABLES MEASUREMENT; MIXING; PROJECT MANAGEMENT; SUSPENSIONS (FLUIDS);

BATCH VESSELS; MIXING PROCESSES; ON-LINE CONTROL; REACTOR GEOMETRIES;

DRUG PRODUCTS;

COMPUTATIONAL FLUID DYNAMICS; STIRRED TANK;

EID: 22744443565     PISSN: 02638762     EISSN: None     Source Type: Journal    
DOI: 10.1205/cherd.04324     Document Type: Article

References (37)

1. Altway, A., Setyawan, H., Margono, and Winardi, S., 2001, Effect of particle size on simulation of three-dimensional solid dispersion in stirred tank, Trans IChemE, Part A, Chem Eng Res Des, 79A: 1011-1016.
2. Armenante, P.M. and Nagamine, E.U., 1998, Effect of low off-bottom impeller clearance on the minimum agitation speed for complete suspension of solids in stirred tanks, Chem Eng Sci, 53: 1757-1775.
3. Bolton, G.T., Qiu, C.H. and Wang, M., 2002, A novel electrical tomography sensor for monitoring the phase distribution in industrial reactors, Proc 7th UK Conference on Mixing, Bradford, UK.
4. Bourne, J.R., Dossenbach, O. and Post, T., 1984, Local and average mass and heat transfer generated by Pfaudler type impellers, IChemE Symp Series, 89: 177-192.
5. Bruggeman, D.A.G., 1935, Berechnung verschiedener physikalisher konstanten von heterogenen substanzen, Ann Phys Leipzig, 24: 636.
6. Bujalski, W., Takenaka, K., Paolini, S., Jahoda, M., Paglianti, A., Takahashi, K., Nienow, A.W. and Etchells, A.W., 1999, Suspensions and liquid homogenisation in high solids concentration stirred chemical reactors, Trans IChemE, Part A, Chem Eng Res Des, 77: 241-247.
7. Decker, S. and Sommerfeld, M., 1996, Calculation of particle suspension in agitated vessels with the Euler-Lagrange approach, IChemE Symp Series, 140: 71-82.
8. Dickin, F.J. and Wang, M., 1996, Electrical resistance tomography for process applications, Meas Sci Technol, 7: 247-260.
9. Durand-Vidal, S., Turq, P., Bernard, O., Treiner, C. and Blum, L., 1996, New perspectives in transport phenomena in electrolytes, Physica A, 231: 123-143.
10. Dyakowski, T., Mikos, M., Vlaev, D., Mann, R., Follows, G.W., Boxman, A. and Wilson, M.P.W., 1999, Imaging Nylon polymerisation processes by applying Electrical Tomography, Proc of the 1st World Congress on Industrial Process Tomography, VCIPT, Buxton, UK.
11. Harnby, N., Edwards, M.F. and Nienow, A.W., 1992, Mixing in the Process Industries, 2nd edition, ISBN 0 7506 1110 3 (Butterworth Heinemann, London, UK).
12. Hattou, S. and Costes, J., 1997, Power, macromixing and micromixing in De Dietrich standard reactors, Recents Progres en Genie des Procedes, 11: 399-396.
13. Hicks, M.T. Myers, K.J. and Bakker, A., 1997, Cloud height in solids suspension agitation, Chem Eng Commun, 160: 137-155.
14. Jones, O.C., 1983, Two-phase flow measurement techniques in gas-liquid systems, in Goldstein, R.J. (ed.), Fluid Mechanics Measurement, pp. 479-558 (Hemisphere Publishing Corp., Washington, USA).
15. Kohnen, C. and Bohnet, M.. 2001, Measurement and simulation of fluid flow in agitated solid-liquid suspensions, Chem Eng Tech, 24: 639-643.
16. Lines, P.C. and Carpenter, K.J., 1990, The effect of physical property ranges on correlations for minimum impeller speeds to disperse immiscible liquid mixtures, IChemE Symp Series, 121: 167-182.
17. Ljungqvist, M. and Rasmuson, A., 2001, Numerical simulation of the two-phase flow in an axially stirred vessel, Trans IChemE, Part A, Chem Eng Res Des, 79: 533-546.
18. Luo, J.Y., Issa, R.I. and Gosman, A.D., 1994, Prediction of impeller-induced flow using multiple frames of reference, IChemE Symp Series, 136: 549-556.
19. Mann, R., Williams, R.A., Dyakowski, T., Dickin, F.J. and Edwards. R.B., 1997, Development of mixing models using electrical resistance tomography, Chem Eng Sci, 52(13): 2073-2085.
20. Maxwell, J.C., 1881, A Treatise on Electricity and Magnetism (Calender Press, Oxford).
21. McKee, S.L., Williams, R.A. and Boxman, A., 1995, Development of solid-liquid mixing models using tomographic techniques, The Chemical Engineering Journal, 56: 101-107.
22. Micale, G., Montante, G., Grisafi, F., Brucato, A. and Godfrey, J., 2000, CFD simulation of particle distribution in stirred vessels, Trans IChemE, Part A, Chem Eng Res Des, 78: 435-444.
23. Montante, G. and Magelli, F., 2003, CFD predictions of solid concentration distributions in baffled and unbaffled vessels agitated with multiple A310 impellers, Proceedings of the 6th Italian Conference on Chemical and Process Engineering, Pisa, Italy.
24. Montante, G., Micale, G., Magelli, F. and Brucato, F., 2001, Experiments and CFD predictions of solid particle distribution in a vessel agitated with four pitched blade turbines, Trans IChemE, Part A, Chem Eng Res Des, 79A: 1005-1010.
25. Ricard, F., Brechtelsbauer, C., Lawrence, C. and Xu, Y., 2003, Application of electrical resistance tomography to pharmaceutical processes, Proc of the 3rd World Congress on Industrial Process Tomography, Banff, Canada.
26. Rielly, C. and Marquis, A., 2001, A particle's eye view of crystallizer fluid mechanics, Chem Eng Sci, 56: 2475-2493.
27. Robin, O., Britten, M. and Paquin, P., 1994, Influence of the dispersed phase distribution on the electrical conductivity of liquid O/W model and dairy emulsions, J Colloid Interface Sci, 167: 401-413.
28. Sharrat, P.N., 1998, Handbook of Batch Process Design, ISBN 0-7514-0369-5 (Blackie Academic and Professional, London, UK).
29. Skelland, A.H.P. and Ramsay, G.G., 1987, Minimum agitator speed for complete liquid-liquid dispersion, Ind Eng Chem Res, 26: 77-81.
30. Stanley, S.J., Wabo, E., Mann, R. and Primrose, K., 2001, Dual-validation of miscible liquid mixing in a stirred vessel imaged by ERT, Proc of 2nd World Con of Ind Proc Tom, Hannover, Germany.
31. Vershuren, I., Wijers, J. and Keurentjes, J., 2000, Mixing with a Pfaudler type impeller: the effect of micromixing on reaction selectivity in the production of fine chemicals, Proc of the l0th European Conference on Mixing, 69-75, Delft, The Netherlands.
32. Wang, F., Wang, W., Wang, Y. and Mao, Z., 2003, CFD simulation of solid-liquid two-phase flow in baffled stirred vessels with Rushton impellers, Proc 3rd Intl Conf on CFD in the Minerals and Process Industries, pp. 287-292, Melbourne, Australia.
33. West, R.M., Jia, X. and Williams, R.A., 1999, Quantification of solid-liquid mixing using electrical resistance and positron emission tomography, Chem Eng Comm, 175: 71-97.
34. Williams, R.A. and Beck, M.S., 1995, Process Tomography: Principles, Techniques and Applications (Butterworth-Heineman, Oxford).
35. Williams, R.A. and Scott, D.M., 1995, Frontiers in Industrial Process Tomography (Engineering Foundation, New York).
36. York, T., 2001, Status of electrical tomography in industrial applications, Journal of Electronic Imaging, 10: 608-619.
37. Zwietering, Th.N., 1958, Suspending of solid particles in liquid by agitators, Chem Eng Sci, 8: 244-253.