Donor CD31 genotype and its association with acute graft-versus-host disease in HLA identical sibling stem cell transplantation

Bone Marrow Transplantation

Volumn 36, Issue 2, 2005, Pages 151-156

  Goodman, Reyna S ^a   Ewing, J ^b   Evans, P C ^c,e   Craig, J ^a   Poulton, K ^d   Dyer, P A ^d   Marcus, R E ^a   Taylor, C J ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b CHRISTIE HOSPITAL   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d MANCHESTER ROYAL INFIRMARY   (United Kingdom)

^e National Kidney Research Foundation

Author keywords

CD31 genotype; Graft versus host disease; Haematopoietic stem cell transplantation

Indexed keywords

ALEMTUZUMAB; CD31 ANTIGEN; CYCLOSPORIN; DNA; LEUCINE; METHOTREXATE; VALINE;

ACUTE GRAFT VERSUS HOST DISEASE; ADOLESCENT; ADULT; ARTICLE; CODON; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE ASSOCIATION; DNA POLYMORPHISM; DONOR; FEMALE; GENOTYPE; HEALTH CARE FACILITY; HETEROZYGOTE; HLA MATCHING; HOMOZYGOTE; HUMAN; HUMAN CELL; INCIDENCE; LEUKOCYTE FUNCTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RECIPIENT; RISK ASSESSMENT; SIBLING; STATISTICAL SIGNIFICANCE; STEM CELL TRANSPLANTATION;

ACUTE DISEASE; ADOLESCENT; ADULT; AMINO ACID SUBSTITUTION; ANTIGENS, CD31; CODON; COHORT STUDIES; FEMALE; GENOTYPE; GRAFT VS HOST DISEASE; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HETEROZYGOTE; HISTOCOMPATIBILITY TESTING; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; SIBLINGS;

EID: 22744432328     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1705013     Document Type: Article

References (14)

1. Goulmy E, Schipper R, Pool J et al. Mismatches of minor histocompatibility antigens between HLA-identical donors and recipients and the development of graft-versus-host disease after bone marrow transplantation. N Engl J Med 1996; 334: 281.
2. Behar E, Chao NJ, Hiraki DD et al. Polymorphism of adhesion molecule CD31 and its role in acute graft-versus-host disease. N Engl J Med 1996; 334: 286.
3. Nichols WC, Antin JH, Lunetta KL et al. Polymorphism of adhesion molecule CD31 is not a significant risk factor for graft-versus-host disease. Blood 1996; 88: 4429.
4. Heinemann FM, Ferencik S, Ottinger HD et al. Impact of disparity of minor histocompatibility antigens HA-1, CD31, and CD49b in hematopoietic stem cell transplantation of patients with chronic myeloid leukemia with sibling and unrelated donors. Transplantation 2004; 77: 1103.
5. Maruya E, Saji H, Seki S et al. Evidence that CD31. CD49b, and CD62L are immunodominant minor histocompatibility antigens in HLA identical sibling bone marrow transplants. Blood 1998; 92: 2169.
6. Grumet FC, Hiraki DD, Brown BW et al. CD31 mismatching affects marrow transplantation outcome. Biol Blood Marrow Transplant 2001; 7: 503.
7. Balduini CL, Francesco F, Noris P et al. Donor-recipient incompatibility at CD31-codon 563 is a major risk factor for acute graft-versus-host disease after allogeneic bone marrow transplantation from a human leucocyte antigen-matched donor. Br J Haematol 2001; 114: 951.
8. Newman PJ. The biology of PECAM-1. J Clin Invest 1997; 99: 3.
9. Colhoun HM, McKeigue PM, Davey Smith G. Problems of reporting genetic associations with complex outcomes. Lancet 2003; 361: 865.
10. Marshall SE, Welsh KI. The role of cytokine polymorphisms in rejection after solid organ transplantation. Genes Immunol 2001; 2: 297.
11. Dickinson AM, Middleton PG, Rocha V et al, on behalf of Eurobank members. Genetic polymorphisms predicting the outcome of bone marrow transplants. Br J Haematol 2004; 127: 479.
12. Cavanagh G, Chapman CE, Carter V et al. Donor CD31 genotype impacts on transplant complications following HLA-matched sibling allogeneic bone marrow transplantation. Transplantation 2005; 79: 602.
13. Sun QH, DeLisser HM, Zukowski MM et al. Individually distinct Ig homology domains in PECAM-1 regulate homophilic binding and modulate receptor affinity. J Biol Chem 1996; 271: 11090.
14. Zhao T, Newman PJ. Integrin activation by regulated dimerization and oligomerization of platelet endothelial cell adhesion molecule (PECAM)-1 from within the cell. J Cell Biol 2001; 152: 65.