-
1
-
-
0030667339
-
Secretase-derived product of β amyloid precursor is decreased by presenilin 1 mutations linked to familial Alzheimer's disease
-
Marambaud P, Dauch P and 1997. α- 69 2494-2499.
-
Ancolio K, Marambaud P, Dauch P and Checler F (1997). α-Secretase-derived product of β amyloid precursor is decreased by presenilin 1 mutations linked to familial Alzheimer's disease. J Neurochem 69 2494-2499.
-
J Neurochem
-
-
Ancolio, K.1
Checler, F.2
-
2
-
-
33747700637
-
Current Protocols in Molecular Biology Volume 2
-
Brent R, Kingston R et al. 1991. England.
-
Ausubel FM, Brent R, Kingston R et al. (1991). Current Protocols in Molecular Biology Volume 2. John Wiley and Son, England.
-
John Wiley and Son
-
-
Ausubel, F.M.1
-
3
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo
-
Thinarkaran G, Eckman CB et al. 1996. 17, 1005-1013.
-
Borchelt DR, Thinarkaran G, Eckman CB et al. (1996). Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron 17, 1005-1013.
-
Neuron
-
-
Borchelt, D.R.1
-
4
-
-
0029805132
-
-
Ooi J, Levy E and 1996. 11 and Fe65 bind to distinct sites on the YENPTY motif of amyloid precursor protein Mol Cell Biol 16, 6229-6241.
-
Borg JP, Ooi J, Levy E and Margolis B (1996). The phosphotyrosine interaction domains of X11 and Fe65 bind to distinct sites on the YENPTY motif of amyloid precursor protein Mol Cell Biol 16, 6229-6241.
-
The Phosphotyrosine Interaction Domains of X
-
-
Borg, J.P.1
Margolis, B.2
-
5
-
-
0026589836
-
Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein
-
Gandy SE, Buxbaum JD and 1992. 89, 2252-2256.
-
Caporaso GL, Gandy SE, Buxbaum JD and Greengard P (1992). Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein. Proc Natl Acad Sci USA 89, 2252-2256.
-
Proc Natl Acad Sci USA
-
-
Caporaso, G.L.1
Greengard, P.2
-
6
-
-
16944362157
-
Mutant Presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein on both transfected cells and transgenic mice
-
Westaway D, Xia W, Carlson G et al. 1997. 3, 67-72.
-
Citron M, Westaway D, Xia W, Carlson G et al. (1997). Mutant Presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein on both transfected cells and transgenic mice. Nature Med 3, 67-72.
-
Nature Med
-
-
Citron, M.1
-
7
-
-
15444341611
-
Post-translational modifications
-
Beullens M, Contreras B and 1997. subcellular localisation and membrane orientation of the Alzheimer's disease associated presenilin's. 272, 3590-3598.
-
De Strooper B, Beullens M, Contreras B and Craessaerts K (1997). Post-translational modifications, subcellular localisation and membrane orientation of the Alzheimer's disease associated presenilin's. J Biol Chem 272, 3590-3598.
-
J Biol Chem
-
-
De Strooper, B.1
Craessaerts, K.2
-
8
-
-
0032556859
-
Deficiency of presenilin 1 inhibits the normal cleavage of amyloid precursor protein
-
Saftig P, Craessaerts K et al. 1998. 391, 387-390.
-
De Strooper B, Saftig P, Craessaerts K et al. (1998). Deficiency of presenilin 1 inhibits the normal cleavage of amyloid precursor protein. Nature 391, 387-390.
-
Nature
-
-
De Strooper, B.1
-
9
-
-
0033535504
-
A presenilin-1-dependent gamma secretase-like protease mediates release of Notch intracellular domain
-
Annett W, Cuprous P et al. 1999. 398, 518-521.
-
De Strooper B, Annett W, Cuprous P et al. (1999). A presenilin-1-dependent gamma secretase-like protease mediates release of Notch intracellular domain. Nature 398, 518-521.
-
Nature
-
-
De Strooper, B.1
-
10
-
-
0025295039
-
Cleavage of amyloid beta peptide during constitutive processing of its precursor
-
Kim PS, Beattie EC et al. 1990. 248, 1122-1124
-
Esch FS, Kim PS, Beattie EC et al. (1990). Cleavage of amyloid beta peptide during constitutive processing of its precursor. Science 248, 1122-1124
-
Science
-
-
Esch, F.S.1
-
11
-
-
0029598484
-
The regions of the Fe65 protein homologous to the phosphotyrosine interaction/ phosphotyrosine binding domain of She bind the intracellular domain of the Alzheimer's amyloid precursor protein
-
Zambrano N, Minopoli G et al. 1995. 270, 30853-30856.
-
Fiore F, Zambrano N, Minopoli G et al. (1995). The regions of the Fe65 protein homologous to the phosphotyrosine interaction/ phosphotyrosine binding domain of She bind the intracellular domain of the Alzheimer's amyloid precursor protein. J Biol Chem 270, 30853-30856.
-
J Biol Chem
-
-
Fiore, F.1
-
12
-
-
0030868903
-
Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease
-
Pettingel WH, Jung Y, Kovacs DM and 1997. 277, 373-376.
-
Kim T, Pettingel WH, Jung Y, Kovacs DM and Tanzi RE (1997). Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science 277, 373-376.
-
Science
-
-
Kim, T.1
Tanzi, R.E.2
-
13
-
-
0028966092
-
Characterisation of sorting signals in the beta-amyloid precursor protein cytoplasmic domain
-
Sisodia SS and 1995. 270, 3565-3573.
-
Lai A, Sisodia SS and Towbridge IS (1995). Characterisation of sorting signals in the beta-amyloid precursor protein cytoplasmic domain. J Biol Chem 270, 3565-3573.
-
J Biol Chem
-
-
Lai, A.1
Towbridge, I.S.2
-
14
-
-
0030811016
-
Hyperaccumulation of FAD-linked presenilin 1 variants in vivo
-
Borchelt DR, Kim G et al. 1997. 3, 756-760.
-
Lee MK, Borchelt DR, Kim G et al. (1997). Hyperaccumulation of FAD-linked presenilin 1 variants in vivo. Nature Med 3, 756-760.
-
Nature Med
-
-
Lee, M.K.1
-
15
-
-
16044365171
-
The E280A presenilin Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology
-
Lopera F, Kosik KS et al. 1996. 2, 1146-1150.
-
Lemere CA, Lopera F, Kosik KS et al. (1996). The E280A presenilin Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology. Nature Med 2, 1146-1150.
-
Nature Med
-
-
Lemere, C.A.1
-
16
-
-
0026688633
-
Mutation of a putative sperm membrane protein in Caenorhabiditis elegans prevents sperm differentiation but not its associated meiotic divisions
-
1992. 119, 55-67.
-
L'Hernault SWL and Arduengo PM (1992). Mutation of a putative sperm membrane protein in Caenorhabiditis elegans prevents sperm differentiation but not its associated meiotic divisions. J Cell Biol 119, 55-67.
-
J Cell Biol
-
-
Swl, L.1
Arduengo, P.M.2
-
17
-
-
0029116848
-
Facilitation of lin-12-mediated signalling by sel-12
-
1995. a Caenorhabiditis elegans S12 Alzheimer's disease gene. 377, 351-354.
-
Levitan D and Greenwald I (1995). Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabiditis elegans S12 Alzheimer's disease gene. Nature 377, 351-354.
-
Nature
-
-
Levitan, D.1
Greenwald, I.2
-
18
-
-
0029906585
-
Assessment of normal and mutant human presenilin function in Caenorhabiditis elegans
-
Doyle TG, Brousseau D et al. 1996. 93, 14940-14944.
-
Levitan D, Doyle TG, Brousseau D et al. (1996). Assessment of normal and mutant human presenilin function in Caenorhabiditis elegans. Proc Natl Acad Sci USA 93, 14940-14944.
-
Proc Natl Acad Sci USA
-
-
Levitan, D.1
-
19
-
-
0029087026
-
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
-
1995. 269, 973-977.
-
Levy-Lahad E. Wasco W. Poorkaj P et al. (1995). Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269, 973-977.
-
Science
-
-
-
20
-
-
0029416825
-
High levels of amyloid-β-protein from S182
-
Turner BA, Carroll RT et al. 1995. Glu246 familial Alzheimer's disease. 7, 217-220.
-
Martins RN, Turner BA, Carroll RT et al. (1995). High levels of amyloid-β-protein from S182(Glu246) familial Alzheimer's disease. NeuroReport 7, 217-220.
-
NeuroReport
-
-
Martins, R.N.1
-
21
-
-
0012510759
-
Amyloid plaque core protein in Alzheimer's disease and Down Syndrome
-
Simms G, Weinman NA et al. 1985. 82, 4245-4249.
-
Masters CL, Simms G, Weinman NA et al. (1985). Amyloid plaque core protein in Alzheimer's disease and Down Syndrome. Proc Natl Acad Sci USA 82, 4245-4249.
-
Proc Natl Acad Sci USA
-
-
Masters, C.L.1
-
22
-
-
0029964851
-
Signal transduction through beta-catenin and specification of cell fate during embryogenesis
-
1996. 10, 2527-2539.
-
Miller JR and Moon RT (1996). Signal transduction through beta-catenin and specification of cell fate during embryogenesis. Genes and Devel 10, 2527-2539.
-
Genes and Devel
-
-
Miller, J.R.1
Moon, R.T.2
-
23
-
-
0031866596
-
Direct association of presenilin-1 with beta-catenin
-
Tanaka S, Palacino J et al. 1998. 433, 73-77
-
Murayama M, Tanaka S, Palacino J et al. (1998). Direct association of presenilin-1 with beta-catenin. FEBS letts 433, 73-77
-
FEBS Letts
-
-
Murayama, M.1
-
24
-
-
0032905727
-
Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin
-
Yu G, Levesque G et al. 1999. a component of the presenilin protein complex. 5, 164-169.
-
Nishimura M, Yu G, Levesque G et al. (1999). Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex. Nature Med 5, 164-169.
-
Nature Med
-
-
Nishimura, M.1
-
25
-
-
0027389118
-
Identification of the Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells
-
Caporaso GL, Thyberg J et al. 1993. 268, 608-612.
-
Nordstedt C, Caporaso GL, Thyberg J et al. (1993). Identification of the Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells. J Biol Chem 268, 608-612.
-
J Biol Chem
-
-
Nordstedt, C.1
-
26
-
-
0027053399
-
N-linked glycosylated of β-amyloid precursor protein
-
Shakin-Eshelmen S and 1992. 189, 1667-1673.
-
Pahlsson P, Shakin-Eshelmen S and Spitalnik SL (1992). N-linked glycosylated of β-amyloid precursor protein. Biochem Biophys Res Comm 189, 1667-1673.
-
Biochem Biophys Res Comm
-
-
Pahlsson, P.1
Spitalnik, S.L.2
-
27
-
-
0030889220
-
Presenilin proteins undergoheterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- And C terminal fragments in normal and Alzheimer brain tissue
-
Citron M, Amarante P et al. 1997. 3, 325-337.
-
Podlisny MB, Citron M, Amarante P et al. (1997). Presenilin proteins undergoheterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C terminal fragments in normal and Alzheimer brain tissue. Neurobiol Dis 3, 325-337.
-
Neurobiol Dis
-
-
Podlisny, M.B.1
-
28
-
-
0030854388
-
Endoproteolytic processing and stabilisation of wild-type and mutant presenilin
-
Slunt HH, Thinakaran G et al. 1997. 272, 24536-24541.
-
Ratovitski T, Slunt HH, Thinakaran G et al. (1997). Endoproteolytic processing and stabilisation of wild-type and mutant presenilin. J Biol Chem 272, 24536-24541.
-
J Biol Chem
-
-
Ratovitski, T.1
-
29
-
-
0033014046
-
Evidence for a physical interaction between presenilin and Notch
-
Yao M, Nowotny P et al. 1999. 96, 3263-3268.
-
Ray W, Yao M, Nowotny P et al. (1999). Evidence for a physical interaction between presenilin and Notch. Proc Natl Acad Sci USA 96, 3263-3268.
-
Proc Natl Acad Sci USA
-
-
Ray, W.1
-
30
-
-
0032575559
-
X11 interaction with beta-amyloid precursor protein modulates its cellular stabilisation and reduces amyloid beta-protein secretion
-
Turner RS and 1998. 273, 22351-22357.
-
Sastre M, Turner RS and Levy E (1998). X11 interaction with beta-amyloid precursor protein modulates its cellular stabilisation and reduces amyloid beta-protein secretion. J Biol Chem 273, 22351-22357.
-
J Biol Chem
-
-
Sastre, M.1
Levy, E.2
-
31
-
-
16044373524
-
Fibroblasts from carriers of familial AD Linked to chromosome 14 show increased Aβ production
-
Eckman C, Jensen M et al. 1996. 2, 864-870.
-
Scheuner D, Eckman C, Jensen M et al. (1996). Fibroblasts from carriers of familial AD Linked to chromosome 14 show increased Aβ production. Nature Med 2, 864-870.
-
Nature Med
-
-
Scheuner, D.1
-
32
-
-
0027459686
-
Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide
-
Oltersdorf T, Lee MG et al. 1993. 361, 260-263.
-
Seubert P, Oltersdorf T, Lee MG et al. (1993). Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide. Nature 361, 260-263.
-
Nature
-
-
Seubert, P.1
-
33
-
-
0026721943
-
Beta-amyloid precursor protein cleavage by a membrane-bound protease
-
1992. 89, 6075-6079.
-
Sisodia SS (1992). Beta-amyloid precursor protein cleavage by a membrane-bound protease. Proc Natl Acad Sci. USA 89, 6075-6079.
-
Proc Natl Acad Sci. USA
-
-
Sisodia, S.S.1
-
34
-
-
15844425969
-
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
-
Borchelt DR, Lee M et al. 1996. 17, 181-190.
-
Thinakaran G, Borchelt DR, Lee M et al. (1996). Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17, 181-190.
-
Neuron
-
-
Thinakaran, G.1
-
35
-
-
33747636882
-
Ageing and the dementias
-
1992. eds. Oxford University Press, New York: pp. 1284-1410.
-
Tomlinson BE (1992). Ageing and the dementias. In:Adams JH and Duchen LW (eds). Oxford University Press, New York: pp. 1284-1410.
-
In:Adams JH and Duchen LW
-
-
Tomlinson, B.E.1
-
36
-
-
0031581057
-
Presenilin 1 binds to amyloid precursor protein directly
-
Imafuku I, Takeuchi S et al. 1997. 239, 480-482.
-
Waragai M, Imafuku I, Takeuchi S et al. (1997). Presenilin 1 binds to amyloid precursor protein directly. Biochem Biophys Res Comm 239, 480-482.
-
Biochem Biophys Res Comm
-
-
Waragai, M.1
-
37
-
-
0024550204
-
Identification
-
Konig G, Bunke D et al. 1989. biogenesis and localisation of precursors of Alzheimer's disease A4 amyloid protein. 57, 115-126.
-
Weidemann A, Konig G, Bunke D et al. (1989). Identification, biogenesis and localisation of precursors of Alzheimer's disease A4 amyloid protein. Cell 57, 115-126.
-
Cell
-
-
Weidemann, A.1
-
38
-
-
0031054505
-
Formation of stable complexes between two Alzheimer's disease gene products: Presenilin 2 and β-amyloid precursor protein
-
Paliga K, Durrwang C et al. 1997. 3, 328-332.
-
Weidemann A, Paliga K, Durrwang C et al. (1997). Formation of stable complexes between two Alzheimer's disease gene products: presenilin 2 and β-amyloid precursor protein. Nature Med 3, 328-332.
-
Nature Med
-
-
Weidemann, A.1
-
39
-
-
0033535553
-
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
-
Xia W, Ostaszewski BL et al. 1999. 398, 513-517.
-
Wolfe MS, Xia W, Ostaszewski BL et al. (1999). Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 398, 513-517.
-
Nature
-
-
Wolfe, M.S.1
-
40
-
-
16944365745
-
Enhanced production and oligomerization of the 42-residue Amyloid
-
Zhang J, Kholodenko D et al. 1997a. β-protein by Chinese hamster ovary cells stably expressing mutant presenilins. 272, 7977-7982.
-
Xia W, Zhang J, Kholodenko D et al. (1997a). Enhanced production and oligomerization of the 42-residue Amyloid (β)-protein by Chinese hamster ovary cells stably expressing mutant presenilins. J Biol Chem 272, 7977-7982.
-
J Biol Chem
-
-
Xia, W.1
-
41
-
-
0030753089
-
Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer's disease
-
Zhang J, Perez R et al. 1997b. 94, 8208-8213.
-
Xia W, Zhang J, Perez R et al. (1997b). Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer's disease. Proc Natl Acad Sci USA 94, 8208-8213.
-
Proc Natl Acad Sci USA
-
-
Xia, W.1
-
42
-
-
0032568821
-
The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin
-
Chen F, Levesque G and 1998. 273, 16470-16475.
-
Yu G, Chen F, Levesque G and Nishimura M (1998). The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin. J Biol Chem 273, 16470-16475.
-
J Biol Chem
-
-
Yu, G.1
Nishimura, M.2
|