Hepatotoxicity of the methanol extract of Carica papaya (Paw-Paw) seeds in wistar rats

Pharmaceutical Biology

Volumn 43, Issue 4, 2005, Pages 349-352

  Udoh, Francis V ^a   Udoh, Paul B ^a  

^a UNIVERSITY OF CALABAR   (Nigeria)

Author keywords

Carica papaya; Hepatotoxicity; Liver sections; Wistar rats

Indexed keywords

ACID PHOSPHATASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CARICA PAPAYA EXTRACT; PLANT EXTRACT; SODIUM CHLORIDE;

ACID PHOSPHATASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD SAMPLING; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; KUPFFER CELL; LIVER CELL; LIVER CIRRHOSIS; LIVER INJURY; LIVER TOXICITY; MALE; METAPLASIA; NONHUMAN; PAPAYA; PLANT SEED; RAT; RAT STRAIN;

ANIMALIA; CARICA PAPAYA; RATTUS NORVEGICUS;

EID: 22644434510     PISSN: 13880209     EISSN: None     Source Type: Journal    
DOI: 10.1080/13880200590951810     Document Type: Article

References (13)

1. Bowman WC, Rand MJ (1980): The liver: Hepatic function and drugs affecting the liver. In: Textbook of Pharmacology, 2nd edition. London: Blackwell Scientific, pp. 3-28.
2. Braide VB (1990): Pharmacological effects of chronic ingestion of Garcinia kola seeds in the rat. Phytother Res 41: 39-41.
3. 2+ and secretary responses in rat pancreatic acini. Eur J Pharmacol 247; 273-281.
4. Cummings AM, Metcalf JL (1995): Methoxychlor regulates rats uterine estrogen-induced protein. Toxicol. Appl. Pharmacol. 130: 154-160.
5. Dalziel JM (1937): The Useful Plants of West Tropical Africa, London: Crown Agents, 612.
6. Georges M, Pandelai KM (1949): Investigation on plants antibiotics IV. Further search for antibiotic substances in Indian medicinal plants. Indian J Med Res 37: 169-181.
7. Grgurevich S, Greene FE (1995): Selective suppression of glotathione-S transferase activity in rat primary hepatocytes by growth hormone. Int J Exp Clin Pharmacol 51: 13-23.
8. Jie L (1995): Suppression of liver cytochrome P450 by L-Hederin: Relevance to hepatoprotection. Toxicol Appl Pharmacol 134: 124-131.
9. Loch JM, Potter J, Bachman KA (1995): The influence of anesthetic agents on rat hepatic cytochromes P450 in vivo. Int J Exp Clin Pharmacol 50: 146-153.
10. Oyedapo OO (1996): Studies on bioactivity of the root extract of Plumbago zeylanica. Int J Pharmacol 34: 365-369.
11. Oyedapo OO, Araba BG (2001): Stimulation of protein biosynthesis in rat hepatocytes by extracts of Momordica charantia. Phytother Res 15: 95-98.
12. Reitman S, Frankel S (1957): A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Am J Clin Pathol 28: 56-62.
13. Udoh P, Kehinde A (1999): Studies on antifertility effect of pawpaw seeds (Carica papaya) on the gonads of male albino rats. Phytother Res 13: 226-228.