Tamoxifen may increase insulin requirement in breast cancer patients with type 1 diabetes mellitus through its agonistic activity on splenic endothelial cells and inhibitory effect on pancreatic beta cells [3]

Medical Hypotheses

Volumn 65, Issue 4, 2005, Pages 815-816

  Kurt, Mevlut ^a   Altundag, Kadri ^a   Altundag, Ozden ^b   Turen, Selahattin ^c  

^a HACETTEPE UNIVERSITY   (Turkey)

^b Institute of Oncology ^*  (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYTAMOXIFEN; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; INSULIN; SEX HORMONE; TAMOXIFEN;

AUTOIMMUNE DISEASE; BREAST CANCER; DISEASE SEVERITY; ENDOTHELIUM CELL; HUMAN; HYPERGLYCEMIA; HYPERLIPIDEMIA; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; INFLAMMATORY CELL; INSULIN DEPENDENT DIABETES MELLITUS; LETTER; LYMPHOID ORGAN; MICROVASCULATURE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SPLEEN; SPLEEN CELL; SYSTEMIC LUPUS ERYTHEMATOSUS;

BREAST NEOPLASMS; DIABETES MELLITUS, TYPE 1; ENDOTHELIAL CELLS; FEMALE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; SPLEEN; TAMOXIFEN;

EID: 22544473628     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2005.05.001     Document Type: Letter

References (6)

1. R.L. Wilder Hormones, pregnancy, and autoimmune diseases Ann N Y Acad Sci 840 1998 4550
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4. M. Cutertre, and C.L. Smith Molecular mechanisms of selective estrogen receptor modulator (SERM) action J Pharmacol Exp Ther 295 2000 4317
5. Y. Hozumi, M. Kawano, and M. Miyata Severe hypertriglyceridemia caused by tamoxifen-treatment after breast cancer surgery Endocr J 44 1997 745 749
6. L. Best Inhibition of glucose-induced electrical activity by 4-hydroxytamoxifen in rat pancreatic beta-cells Cell Signal 14 2002 69 73