Abnormal glucose homeostasis and pancreatic islet function in mice with inactivation of the Fem1b gene

Molecular and Cellular Biology

Volumn 25, Issue 15, 2005, Pages 6570-6577

  Lu, Deyin ^a,b   Ventura Holman, Tereza ^a,b   Li, Jing ^a,b   McMurray, Robert W ^b   Subauste, Jose S ^a,b   Maher, Joseph F ^a,b,c  

^a G V SONNY MONTGOMERY VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CALPAIN; CALPAIN 10; GLUCOSE; INSULIN; PROTEIN PATCHED; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; FEM 1 GENE; FEM1B GENE; FEMALE; GENE; GENE EXPRESSION; GENE INACTIVATION; GENOTYPE ENVIRONMENT INTERACTION; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; INSULIN RELEASE; KNOCKOUT MOUSE; MALE; MOUSE; NEMATODE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS FUNCTION; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SEX DETERMINATION; TRA 2 GENE; TRA 3 GENE;

ANIMALS; CARRIER PROTEINS; CELL CYCLE PROTEINS; GENE SILENCING; GLUCOSE; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; ISLETS OF LANGERHANS; MICE; MICE, KNOCKOUT; RATS; TIME FACTORS;

ERINACEIDAE; MAMMALIA;

EID: 22544467228     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.25.15.6570-6577.2005     Document Type: Article

References (41)

1. Asfari, M., D. Janjic, P. Meda, G. Li, P. A. Halban, and C. B. Wollheim. 1992. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130:167-178.
2. Barnes, T. M., and J. Hodgkin. 1996. The tra-3 sex determination gene of Caenorhabditis elegans encodes a member of the calpain regulatory protease family. EMBO J. 15:4477-4484.
3. Brissova, M., M. Shiota, W. E. Nicholson, M. Cannon, S. M. Knobel, D. W. Piston, C. V. Wright, and A. C. Powers. 2002. Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J. Biol. Chem. 277:11225-11232.
4. Chan, S. L., K. O. Tan, L. Zhang, K. S. Yee, F. Ronca, M. Y. Chan, and V. C. Yu. 1999. F1Aα, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis. J. Biol. Chem. 274:32461-32468.
5. Chervonsky, A. V., Y. Wang, F. S. Wong, I. Visintin, R. A. Flavell, C. A. Janeway, Jr., and L. A. Matis. 1997. The role of Fas in autoimmune diabetes. Cell 89:17-24.
6. Cho, H., J. Mu, J. K. Kim, J. L. Thorvaldsen, Q. Chu, E. B. Crenshaw III, K. H. Kaestner, M. S. Bartolomei, G. I. Shulman, and M. J. Birnbaum. 2001. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ). Science 292:1728-1731.
7. Cox, N. J., M. Frigge, D. L. Nicolae, P. Concannon, C. L. Hanis, G. I. Bell, and A. Kong. 1999. Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans. Nat. Genet. 21: 213-215.
8. Darwiche, R., M. M. Chong, P. Santamaria, H. E. Thomas, and T. W. Kay 2003. Fas is detectable on beta cells in accelerated, but not spontaneous, diabetes in nonobese diabetic mice. J. Immunol. 170:6292-6297.
9. Desai, C., and H. R. Horvitz. 1989. Caenorhabditis elegans mutants defective in the functioning of the motor neurons responsible for egg laying. Genetics 121:703-721.
10. Doniach, T., and J. Hodgkin, 1984. A sex-determining gene, fem-1, required for both male and hermaphrodite development in Caenorhabditis elegans. Dev. Biol. 106:223-235.
11. Efrat, S., and N. Fleischer. 2000. Engineering the pancreatic β-cell, p. 539. In D. LeRoith, S. I. Taylor, and J. M. Olefsky (ed.). Diabetes mellitus-a fundamental and clinical text, 2nd ed. Lippincott Williams & Wilkins, Philadelphia, Pa.
12. Gaudet, J., I. VanderElst, and A. M. Spence. 1996. Post-transcriptional regulation of sex determination in Caenorhabditis elegans: widespread expression of the sex-determining gene fem-1 in both sexes. Mol. Biol. Cell 7:1107-1121.
13. Gerich, J. E. 2002. Is reduced first-phase insulin release the earliest detectable abnormality in individuals destined to develop type 2 diabetes? Diabetes 51(Suppl. 1):S117-S121.
14. Gerich, J. E. 2003. Clinical significance, pathogenesis, and management of postprandial hyperglycemia. Arch. Intern. Med. 163:1306-1316.
15. Gillies, M. C., and T. E. Mandel. 1990. The evolution of function and response to arginine challenge and pregnancy of portally and systemically placed islet cell grafts in streptozotocin diabetic mice. Metabolism 39:1253-1258.
16. Hebrok, M., S. K. Kim, B. St. Jacques, A. P. McMahon, and D. A. Melton. 2000. Regulation of pancreas development by hedgehog signaling. Development 127:4905-4913.
17. Hodgkin, J. 1987. Sex determination and dosage compensation in Caenorhabditis elegans. Annu. Rev. Genet. 21:133-154.
18. Hodgkin, J., T. Doniach, and M. Shen. 1985. The sex determination pathway in the nematode Caenorhabditis elegans: variations on a theme. Cold Spring Harbor Symp. Quant. Biol. 50:585-593.
19. Horikawa, Y., N. Oda, N. J. Cox, X. Li, M. Orho-Melander, M. Hara, Y. Hinokio, T. H. Lindner, H. Mashima, P. E. Schwarz, L. del Bosque-Plata, Y. Horikawa, Y. Oda, I. Yoshiuchi, S. Colilla, K. S. Polonsky, S. Wei, P. Concannon, N. Iwasaki, J. Schulze, L. J. Baier, C. Bogardus, L. Groop, E. Boerwinkle, C. L. Hanis, and G. I. Bell. 2000. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat. Genet. 26:163-175.
20. Jager, S., H. T. Schwartz, H. R. Horvitz, and B. Conradt. 2004. The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome. Proc. Natl. Acad. Sci. USA 101:12549-12554.
21. Johnson, J. D., Z. Han, K. Otani, H. Ye, Y. Zhang, H. Wu, Y. Horikawa, S. Misler, G. I. Bell, and K. S. Polonsky. 2004. RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets. J. Biol. Chem. 279:24794-24802.
22. Krakow, D., E. Sebald, L. M. King, and D. H. Cohn. 2001. Identification of human FEM1A, the ortholog of a C. elegans sex-differentiation gene. Gene 279:213-219.
23. Kulkarni, R. N., M. Holzenberger, D. Q. Shih, U. Ozcan, M. Stoffel, M. A. Magnuson, and C. R. Kahn. 2002. Beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat. Genet. 31:111-115.
24. Kuwabara, P. E., P. G. Okkema, and J. Kimble. 1992. tra-2 encodes a membrane protein and may mediate cell communication in the Caenorhabditis elegans sex determination pathway. Mol. Biol. Cell 3:461-473.
25. Mansour, S. L., K. R. Thomas, and M. R. Capecchi. 1988. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 336:348-352.
26. Merglen, A., S. Theander, B. Rubi, G. Chaffard, C. B. Wollheim, and P. Maechler. 2004. Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells. Endocrinology 145:667-678.
27. Puoti, A., M. Gallegos, B. Zhang, M. P. Wickens, and J. Kimble. 1997. Controls of cell fate and pattern by 3′ untranslated regions: the Caenorhabditis elegans sperm/oocyte decision. Cold Spring Harbor Symp. Quant. 62: 19-24.
28. Sambrook, J., and D. W. Russell. 2001. Molecular cloning: a laboratory manual, 3rd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
29. Savinov, A. Y., A. Tcherepanov, E. A. Green, R. A. Flavell, and A. V. Chervonsky. 2003. Contribution of Fas to diabetes development. Proc. Natl. Acad. Sci. USA 100:628-632.
30. Sokol, S. B., and P. E. Kuwabara. 2000. Proteolysis in Caenorhabditis elegans sex determination: cleavage of TRA-2A by TRA-3. Genes Dev. 14:901-906.
31. Spence, A. M., A. Coulson, and J. Hodgkin. 1990. The product of fem-1, a nematode sex-determinating gene, contains a motif found in cell cycle control proteins and receptors for cell-cell interactions. Cell 60:981-990.
32. Sreenan, S. K., Y. P. Zhou, K. Otani, P. A. Hansen, K. P. Currie, C. Y. Pan, J. P. Lee, D. M. Ostrega, W. Pugh, Y. Horikawa, N. J. Cox, C. L. Hanis, C. F. Burant, A. P. Fox, G. I. Bell, and K. S. Polonsky. 2001. Calpains play a role in insulin secretion and action. Diabetes 50:2013-2020.
33. Thomas, H. E., and T. W. Kay. 2000. Beta cell destruction in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse. Diabetes Metab. Res. Rev. 16:251-261.
34. Thomas, M. K., N. Rastalsky, J. H. Lee, and J. F. Habener. 2000. Hedgehog signaling regulation of insulin production by pancreatic β-cells. Diabetes 49:2039-2047.
35. Thomas, M. K., J. H. Lee, N. Rastalsky, and J. F. Habener. 2001. Hedgehog signaling regulation of homeodomain protein islet duodenum homeobox-1 expression in pancreatic beta-cells. Endocrinology 142:1033-1040.
36. Ventura-Holman, T., M. F. Seldin, W. Li, and J. F. Maher. 1998. The murine Fem1 gene family: homologs of the Caenorhabditis elegans sex-determination protein FEM-1. Genomics 54:221-230.
37. Ventura-Holman, T., and J. F. Maher. 2000. Sequence, organization, and expression of the human FEM1B gene. Biochem. Biophys. Res. Commun. 267:317-320.
38. Ventura-Holman, T., D. Lu, X. Si, E. B. Izevbigie, and J. F. Maher. 2003. The Fem1c genes: conserved members of the Fem1 gene family in vertebrates. Gene 314:133-139.
39. Ventura-Holman, T., N. B. Hander, and J. F. Maher. 2000. The human FEM1B gene maps to chromosome 15q22 and is excluded as the gene for Bardet-BiedI syndrome, type 4. Am. J. Med. Sci. 319:268-270.
40. Zarkower, D., and J. Hodgkin. 1992. Molecular analysis of the C. elegans sex-determining gene tra-1: a gene encoding two zinc finger proteins. Cell 70:237-249.
41. Zhou, Y. P., S. Sreenan, C. Y. Pan, K. P. Currie, V. P. Bindokas, Y. Horikawa, J. P. Lee, D. Ostrega, N. Ahmed, A. C. Baldwin, N. J. Cox, A. P. Fox, R. J. Miller, G. I. Bell, and K. S. Polonsky. 2003. A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin. Metabolism 52:528-534.