Diastereoisomerically selective enantiomerically pure titanium complexes of salan ligands: Synthesis, structure, and preliminary activity studies

Inorganic Chemistry

Volumn 44, Issue 13, 2005, Pages 4466-4468

  Yeori, Adi ^a   Groysman, Stanislav ^a   Goldberg, Israel ^a   Kol, Moshe ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 22544457898     PISSN: 00201669     EISSN: None     Source Type: Journal    
DOI: 10.1021/ic050745b     Document Type: Article

References (20)

1. Catalytic Asymmetric Synthesis, 2nd ed.; Ojima, I., Ed.; Wiley-VCH: New York, 2000.
2. Brintzinger, H. H.; Fischer, D.; Mülhaupt, R.; Rieger, B.; Waymouth, R. M. Angew. Chem., Int. Ed. Engl. 1995, 34, 1143.
3. (a) Tshuva, E. Y.; Goldberg, I.; Kol, M. J. Am. Chem. Soc. 2000, 122, 10706.
4. (b) Segal, S.; Goldberg, I.; Kol, M. Organometallics 2005, 24, 200.
5. For several examples of employing chiral metallocenes in asymmetric transformations following their resolution, see: (a) Waymouth, R. M.; Pino, P. J. Am. Chem. Soc. 1990, 112, 4911.
6. (b) Troutman, M. V.; Appella, D. H.; Buchwald, S. L. J. Am. Chem. Soc. 1999, 121, 4916.
7. (c) Hansen, M. C.; Buchwald, S. L. Org. Lett. 2000, 2, 713.
8. (a) Knof, U.; von Zelewsky, A. Angew. Chem., Int. Ed. 1999, 38, 302.
9. (b) Mamula, O.; von Zelewsky, A. Coord. Chem. Rev. 2003, 242, 87.
10. In contrast, fac-mer dinuclear complexes of Salan ligands around aluminum were reported: Wei, P.; Atwood, D. A. Polyhedron 1999, 18, 641.
11. Balsells, J.; Carroll, P. J.; Walsh, P. J. Inorg. Chem. 2001, 40, 5568.
12. 2 = 0.1140 for all 3363 unique reflections.
13. All crystallographic measurements were made with high precision at ca. 110 K, with a clear indication of the structures' chirality.
14. 2.
15. 2 = 0.1421 for all 2815 unique reflections.
16. 2 = 0.1220 for all 2797 unique reflections.
17. 8-toluene taken at 90°C did not exhibit any new peaks, and upon cooling to room temperature, it was identical to the original spectrum. We thus propose that the diastereoisomeric purity of these complexes is not compromised during the catalytic reaction course.
18. For asymmetric catalysis employing dinuclear fac-mer Salan aluminum complexes, see: Ward, C. V.; Jiang, M.; Kee, T. P. Tetrahedron Lett. 2000, 41, 6181.
19. For asymmetric catalysis employing a Salan titanium complex, see: Dai, Z.; Zhu, C.; Yang, M.; Zheng Y.; Pan, Y. Tetrahedron: Assymetry 2005, 16, 605.
20. Mori, M.; Nakai, T. Tetrahedron Lett. 1997, 38, 6233.