Increased procoagulant phospholipid activity in blood from patients with suspected acute coronary syndromes: A pilot study

Blood Coagulation and Fibrinolysis

Volumn 16, Issue 5, 2005, Pages 375-379

  Exner, Thomas ^a   Joseph, Joanne E ^a   Connor, David ^a   Low, Joyce ^a   Ma, David D F ^a  

^a ST VINCENT S HOSPITAL   (Australia)

Author keywords

Acute coronary syndrome; Microparticles; Procoagulant phospholipid

Indexed keywords

EDETIC ACID; PHOSPHOLIPID; PROCOAGULANT; TROPONIN I;

ANGIOCARDIOGRAPHY; ARTICLE; BLOOD; BLOOD CLOTTING TIME; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; ELECTROCARDIOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HEART MUSCLE ISCHEMIA; HUMAN; MALE; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION;

EID: 22444437326     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mbc.0000173465.45613.a3     Document Type: Article

References (19)

1. Handin RI, McDonough M, Lesech M. Elevation of platelet factor four in acute myocardial infarction measured by radioimmunoassay. J Lab Clin Med 1978; 91:340-349.
2. Pumphery CW, Dawes J. Plasma beta thromboglobulin as a measure of platelet activity. Effect of risk factors and findings in ischaemic heart disease and after acute myocardial infarction. Am J Cardiol 1982; 50:1258-1261.
3. Atalar E, Aytemir K, Haznedaroglu I, Ozer N, Ovunc K, Aksoyek S, et al. Increased levels of soluble selectins in patients with unstable angina. Int J Cardiol 2001; 78:69-73.
4. Michaelson AD, Furman MI. Laboratory markers of platelet activation and their clinical significance. Curr Opin Haematol 1999; 6:342-348.
5. Holme PA, Orvin U, Hamers MJ, Solum NO, Brosstadt FR, Barstad RM, Sakariassen KS. Shear-induced platelet activation and platelet microparticle formation at blood flow conditions as in arteries with a severe stenosis. Arterioscler Thromb Vasc Biol 1997; 17:646-653.
6. Jy W, Horstman LL, Fang W, Duncan RC, Ahn YS. Platelet factor 3 in plasma fractions: its relation to microparticle size and thrombosis. Thromb Res 1995; 80:471-482.
7. Exner T, Joseph J, Low J, Connor D, Ma D. A new activated factor Xa-based clotting method with improved specificity for procoagulant phospholipid. Blood Coagul Fibrinolysis 2003; 14:773-779.
8. Joint European Society of Cardiology/American College of Cardiology Committee. Myocardial infarction redefined: a consensus document of the Joint European Society of Cardiology/American College of Cardiology committee for the redefinition of myocardial infarction. Eur Heart J 2000; 21:1502-1513.
9. Connor DE, Joseph J, Exner T, Ma D. A novel coagulation assay used to detect procoagulant phospholipid correlates with microparticle numbers in resting and collagen-stimulated samples [Abstract]. Pathophysiol Haemost Thromb 2004; 33:69.
10. Berckmans RJ, Nieuwland R, Boing AN, Romijn FPHT, Erik Hack C, Sturk A. Cell derived microparticles circulate in healthy humans and support low grade thrombin generation. Thromb Haemost 2001; 85:639-646.
11. Joop K, Berckmans PJ, Nieuwland R, Berkhout J, Romijn FPHT, Hack CE, Sturk A. Microparticles from patients with multiple organ dysfunction syndrome and sepsis support coagulation through multiple mechanisms. Thromb Haemost 2001; 85:810-820.
12. Geiser T, Sturzenegger M, Genewein U, Haeberli A, Beer JH. Mechanism of cerebrovascular events as assessed by procoagulant activity, cerebral microemboli and platelet microparticles in patients with prosthetic heart valves. Stroke 1998; 29:1770-1777.
13. Singh N, Gemmell CH, Daly PA, Yeo EL. Elevated platelet-derived microparticle levels during unstable angina. Can J Cardiol 1995; 11:1015-1021.
14. Wagenvoord PJ, Hendrix HH, Kai H, Hemker HC. A chromogenic test to determine the procoagulant phospholipids in platelet-rich plasma and whole blood. Thromb Haemost 1994; 72:582-587.
15. McEver RP. Adhesive interactions of leukocytes, platelets and the vessel wall during hemostasis and inflammation. Thromb Haemost 2001; 86:746-756.
16. Sarma J, Laan CA, Alam S, Jha A, Fox KA, Dransfield I. Increased platelet binding to circulating monocytes in acute coronary syndromes. Circulation 2002; 105:2166-2171.
17. 7 Ott I, Neumann FJ, Gawaz M, Schmitt M, Schomig A. Increased neutrophil-platelet adhesion in patients with unstable angina. Circulation 1996; 94:1239-1246.
18. Joseph JE, Harrison P, Mackie IJ, Isenberg DA, Machin SJ. Increased circulating platelet-leukocyte complexes and platelet activation in patients with antiphospholipid syndrome, systemic lupus erythematosus and rheumatoid arthritis. Br J Haematol 2001; 115:451-459.
19. Rhoades P, Margolis J, Lovric VA. Red cell stroma, a stable standard for assessment of platelet procoagulant release. Pathology 1979; 11:161-167.