Exercise and the lymphatic system: Implications for breast-cancer survivors

Sports Medicine

Volumn 35, Issue 6, 2005, Pages 461-471

  Lane, Kirstin ^a,b   Worsley, Dan ^a   McKenzie, Don ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; NORADRENALIN;

AXILLARY LYMPH NODE; BLOOD FLOW; BREAST CANCER; CANCER SURVIVAL; CANCER THERAPY; CARDIOVASCULAR SYSTEM; ENDOTHELIUM CELL; EXERCISE; FLOW KINETICS; HUMAN; HYDROSTATIC PRESSURE; INTERSTITIAL FLUID; LYMPH FLOW; LYMPH NODE DISSECTION; LYMPH VESSEL; LYMPHATIC DRAINAGE; LYMPHATIC SYSTEM; LYMPHEDEMA; LYMPHOSCINTIGRAPHY; MUSCLE CONTRACTION; MUSCLE ISOMETRIC CONTRACTION; PATHOPHYSIOLOGY; PHYSIOTHERAPY; REVIEW; SMOOTH MUSCLE; STEADY STATE;

BREAST NEOPLASMS; EXERCISE; FEMALE; HUMANS; LYMPHATIC SYSTEM; LYMPHEDEMA; SURVIVORS;

EID: 22344439668     PISSN: 01121642     EISSN: None     Source Type: Journal    
DOI: 10.2165/00007256-200535060-00001     Document Type: Review

References (55)

1. Kent H. Breast-cancer survivors begin to challenge exercise taboos. CMAJ 1996; 155 (7): 969-71
2. Mortimer PS. The pathophysiology of lymphedema. Cancer 1998; 83 (12 Suppl.): 2798-802
3. McKenzie DC, Kalda AL. The effect of upper extremity exercise on secondary lymphedema in breast cancer patients: a pilot study. J Clin Oncol 2003; 21 (3): 463-6
4. Harris SR, Niesen-Vertommen SL. Challenging the myth of exercise-induced lymphedema following breast cancer: a series of case reports. J Surg Oncol Suppl 2000; 74 (2): 95-8
5. Aukland K, Reed RK. Interstitial-lymphatic mechanisms in the control of extracellular fluid volume. Physiol Rev 1993; 73 (1): 1-78
6. Schmid-Schönbein GW. Microlymphatics and lymph flow. Physiol Rev 1990; 70 (4): 987-1028
7. Olszewski W. The lymphatic system in body homeostasis: physiological conditions. Lymphat Res Biol 2003; 1 (1): 11-21
8. Schmid-Schönbein GW. The second valve system in lymphatics. Lymphat Res Biol 2003; 1 (1): 25-31
9. Trzewik J, Mallipattu SK, Artmann GM, et al. Evidence for a second valve system in lymphatics: endothelial microvalves. FASEB J 2001; 15: 1711-7
10. Marieb EN. Human anatomy and physiology. 5th rev ed. San Francisco (CA): Benjamin Cummings, 2001
11. Gashev AA. Physiologic aspects of lymphatic contractile function: current perspectives. Ann N Y Acad Sci 2002; 979: 178-87
12. McHale NG, Roddie IC. The effect of intravenous adrenaline and noradrenaline infusion of peripheral lymph flow in the sheep. J Physiol 1983; 341: 517-26
13. Seabrook TJ, Ristevski B, Rhind SG, et al. Epinephrine causes a reduction in lymph node cell output in sheep. Can J Physiol Pharmacol 2001; 79 (3): 246-52
14. Pain SJ, Purushotham AD. Lymphoedema following surgery for breast cancer. Br J Surg 2000; 87 (9): 1128-41
15. Board J, Harlow W. Lymphoedema 1: components and function of the lymphatic system. Br J Nurs 2002; 11 (5): 304-9
16. Threefoot SA. The clinical significance of lymphaticovenous communications. Ann Intern Med 1970; 72 (6): 957-8
17. Threefoot S, Kossover MF, Aiken DW. Radioisotopic detection of lymphaticovenous communications in living animals. J Lab Clin Med 1965; 65: 688-97
18. Olszewski W, Engeset A. Intrinsic contractility of prenodal lymph vessels and lymph flow in human leg. Am J Physiol 1980; 239: H775-H83
19. McHale NG, Meharg MK. Co-ordination of pumping in isolated bovine lymphatic vessels. J Physiol 1992; 450: 503-12
20. Swartz MA, Boardman KC. The role of interstitial stress in lymphatic function and lymphangiogenesis. Ann N Y Acad Sci 2002; 979: 197-210
21. Swartz MA. The physiology of the lymphatic system. Adv Drug Deliv Rev 2001; 50: 3-20
22. Mazzoni MC, Skalak TC, Schmid-Schönbein GW. Effects of skeletal muscle fiber deformation on lymphatic volumes. Am J Physiol 1990; 259 (6 Pt 2): H1860-8
23. Krasnow AZ, Hellman RS. Lymphoscintigraphy revisited. In: Freeman LM, editor. Nuclear medicine annual. Philadelphia (PA): Lippincott, Williams & Wilkins, 1999: 17-97
24. Szuba A, Shin WS, Strauss HW, et al. The third circulation: Radionuclide lymphoscintigraphy in the evaluation of lymphedema. J Nucl Med 2003; 44: 43-57
25. Bates DO. Novel insight into the pathophysiology of breast-cancer-related lymphoedema. Clin Sci 2001; 101 (2): 169-70
26. Bourgeois P, Leduc O, Leduc A. Imaging techniques in the management and prevention of posttherapeutic upper limb edemas. Cancer 1998; 83 (12 Suppl.): 2805-13
27. Mortimer PS. Evaluation of lymphatic function: abnormal lymph drainage in venous disease. Int Angiol 1995; 14 (3 Suppl. 1): 32-5
28. Pain SJ, Barber RW, Ballinger JR, et al. Tissue-to-blood transport of radiolabelled immunoglobulin injected into the web spaces of the hands of normal subjects and patients with breast cancer-related lymphoedema. J Vasc Res 2004; 41: 183-92
29. Pain SJ, Barber RW, Ballinger JR, et al. Side-to-side symmetry of radioprotein transfer from tissue space to systemic vasculature following subcutaneous injection in normal subjects and subjects with breast cancer. Eur J Nucl Med Mol Imaging 2003; 30 (5): 657-61
30. Pain SJ, Purushotham AD, Barber RW, et al. Variation in lymphatic function may predispose to development of breast cancer-related lymphoedema. Eur J Surg Oncol 2004; 30: 508- 14
31. Stanton AW, Svensson WE, Mellor RH, et al. Differences in lymph drainage between swollen and non-swollen regions in arms with breast-cancer-related lymphoedema. Clin Sci 2001; 101 (2): 131-40
32. Pain SJ, Nicholas RS, Barber RW, et al. Quantification of lymphatic function for investigation of lymphedema: depot clearance and rate of appearance of soluble macromolecules in blood. J Nucl Med 2002; 43 (3): 318-24
33. Williams WH, Witte CL, Witte MH, et al. Radionuclide lymphangioscintigraphy in the evaluation of peripheral lymphedema. Clin Nucl Med 2000; 25 (6): 451-64
34. Szuba A, Strauss W, Sirsikar S, et al. Quantitative radionuclide lymphoscintigraphy predicts outcome of manual lymphatic therapy in breast cancer-related lymphedema of the upper extremity. Nucl Med Commun 2002; 23: 1171-5
35. Gothard L, Stanton A, MacLaren J, et al. Non-randomized phase II trial of hyperbaric oxygen therapy in patients with chronic arm lympoedema and tissue fibrosis after radiotherapy for early breast cancer. Radiother Oncol 2004; 70: 217-24
36. McGeown JG, McHale NG, Thornbury KD. The role of external compression and movement in lymph propulsion in the sheep hind limb. J Physiol 1987; 387: 83-93
37. Coates G, O'Brodovich H, Goeree G. Hindlimb and lung lymph flows during prolonged exercise. J Appl Physiol 1993; 75 (2): 633-8
38. Havas E, Parviainen T, Vuorela J, et al. Lymph flow dynamics in exercising human skeletal muscle as detected by scintography. J Physiol 1997; 504 (Pt 1): 233-9
39. Tesch PA, Wright JE. Recovery from short term intense exercise: its relation to capillary supply and blood lactate concentration. Eur J Appl Physiol 1983; 52: 98-103
40. Havas E, Lehtonen M, Vuorela J, et al. Albumin clearance from human skeletal muscle during prolonged steady-state running. Exp Physiol 2000; 85 (6): 863-8
41. Hinrichs CS, Watroba NL, Rezaishiraz H, et al. Lymphedema secondary to postmastectomy radiation: incidence and risk factors. Ann Surg Oncol 2004; 11 (6): 573-80
42. Ozaslan C, Kuru B. Lymphedema after treatment of breast cancer. Am J Surg 2004; 187 (1): 69-72
43. Petrek JA, Senie RT, Peters M, et al. Lymphedema in a cohort of breast carcinoma survivors 20 years after diagnosis. Cancer 2001; 92 (6): 1368-77
44. Erickson VS, Pearson ML, Ganz PA, et al. Arm edema in breast cancer patients. J Natl Cancer Inst 2001; 93 (2): 96-111
45. Sener SF, Winchester DJ, Martz CH, et al. Lymphedema after sentinel lymphadenectomy for breast carcinoma. Cancer 2001; 92: 748-52
46. Megens AM, Harris SR, Kim-Sing C, et al. Measurement of upper extremity volume in women after axillary dissection for breast cancer. Arch Phys Med Rehabil 2001; 82 (12): 1639-44
47. Harris SR, Hugi MR, Olivotto IA, et al. Clinical practice guidelines for the care and treatment of breast cancer: 11. Lymphedema. CMAJ 2001; 164 (2): 191-9
48. Witte CL, Witte MH, Unger EC, et al. Advances in imaging of lymph flow disorders. Radiographics 2000; 20 (6): 1697-719
49. Bates DO, Levick JR, Mortimer PS. Change in macromolecular composition of interstitial fluid from swollen arms after breast cancer treatment, and its implications. Clin Sci 1993; 85 (6): 737-46
50. Bates DO, Levick JR, Mortimer PS. Subcutaneous interstitial fluid pressure and arm volume in lymphoedema. Int J Microcirc Clin Exp 1992; 11 (4): 359-73
51. Svensson WE, Mortimer PS, Tohno E, et al. Increased arterial inflow demonstrated by Doppler ultrasound in arm swelling following breast cancer treatment. Eur J Cancer 1994; 30A (5): 661-4
52. Stanton AW, Holroyd B, Mortimer PS, et al. Comparison of microvascular filtration in human arms with and without postmastectomy oedema. Exp Physiol 1999; 84: 405-19
53. Mellor RH, Stanton AW, Azarbod P, et al. Enhanced cutaneous lymphatic network in the forearms of women with postmastectomy oedema. J Vasc Res 2000; 37 (6): 501-12
54. Aboul-Enein A, Eshmawy I, Arafa S, et al. The role of lymphovenous communication in the development of postmastectomy lymphedema. Surgery 1984; 95 (5): 562-6
55. McKenzie DC. Abreast in a boat: a race against breast cancer. CMAJ 1998; 159 (4): 376-8