Topical vitamin D3 is effective in treating senile warts possibly by inducing apoptosis

Journal of Dermatology

Volumn 32, Issue 6, 2005, Pages 420-423

  Mitsuhashi, Yoshihiko ^a   Kawaguchi, Masakazu ^a   Hozumi, Yutaka ^a   Kondo, Shigeo ^a  

^a YAMAGATA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Seborrheic keratosis; Senile wart; Tacalcitol; Vitamin D3

Indexed keywords

22 OXACALCITRIOL; CALCIPOTRIOL; COLECALCIFEROL; NITROGEN; TACALCITOL;

ADULT; AGED; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; EDEMA; ERYTHEMA; FEMALE; FREEZING; HUMAN; INFLAMMATION; KERATOSIS; LOW LEVEL LASER THERAPY; MAJOR CLINICAL STUDY; MALE; PSORIASIS; QUALITY OF LIFE; SEBORRHEIC KERATOSIS; SENILE WART; VITAMIN SUPPLEMENTATION; AGE; COHORT ANALYSIS; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ADMINISTRATION; FOLLOW UP; HOSPITALIZATION; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; NEEDLE BIOPSY; PATHOLOGY; PROSPECTIVE STUDY; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME;

ADMINISTRATION, TOPICAL; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; BIOPSY, NEEDLE; CHOLECALCIFEROL; COHORT STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; KERATOSIS, SEBORRHEIC; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 22344439619     PISSN: 03852407     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1346-8138.2005.tb00772.x     Document Type: Article

References (7)

1. MacKie RM, Quinn AG: Seborrheic keratosis, in Burns T, Breathnach S, Cox N, Griffiths C (eds): Textbook of Dermatology, 6th ed, Blackwell, Oxford, 2004, p 36.39-36-41.
2. Kondo S, Hozumi Y, Aso K: Long-term organ culture of rabbit skin: Effect of EGF on epidermal structure in vitro, J Invest Dermatol, 95: 397-402, 1990.
3. Wang XJ, Greenhalgh DA, Lu XR, Bickenbach JR, Roop DR: TGF alpha and v-fos cooperation in transgenic mouse epidermis induces aberrant keratinocyte differentiation and stable, autonomous papillomas. Oncogene, 10: 279-289, 1995.
4. Mitra RS, Wrone-Smith T, Simonian P, et al: Apoptosis in keratinocytes is not dependent on induction of differentiation, Labo Invest, 76: 99-107, 1997.
5. Trump DL, Hershberger PA, Bernardi RJ, et al: Anti-tumor activity of calcitriol: Pre-clinical and clinical studies, J Steroid Biochem Mol Biol, 89-90: 519-526, 2004.
6. 3, transforming growth factor beta1, calcium, and ultraviolet B radiation induce apoptosis in cultured human keratinocytes, J Invest Dermatol, 109: 276-822, 1997.
7. van de Kerkhof PC: Biological activity of vitamin D analogues in the skin, with special reference to antipsoriatic mechanisms, Br J Dermatol, 132: 675-682, 1995.