Placental leucine aminopeptidase might regulate the effects of oxytocin with resolution in endothelial cells

Medical Science Monitor

Volumn 11, Issue 7, 2005, Pages

  Sano, Michiyo ^a   Itakura, Atsuo ^b   Ito, Mitsuaki ^c   Takeuchi, Mikihito ^a   Okada, Mayumi ^a   Kotani, Tomomi ^a   Mizutani, Shigehiko ^a   Kikkawa, Fumitaka ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY HOSPITAL   (Japan)

^c TOYOHASHI MUNICIPAL HOSPITAL   (Japan)

Author keywords

Leucine aminopeptidase; Nitric oxide; Oxytocin; Vascular endothelial cells

Indexed keywords

CALCIUM; CYTOSOL AMINOPEPTIDASE; NITRIC OXIDE; OXYTOCIN; OXYTOCIN RECEPTOR; PLACENTAL LEUCINE AMINOPEPTIDASE; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CELL MEMBRANE; CELL PROLIFERATION; CELL SURFACE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PARAMETER; PLACENTA; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; STATISTICAL SIGNIFICANCE; VASCULAR ENDOTHELIUM; VASODILATATION;

CALCIUM; CELL PROLIFERATION; CELLS, CULTURED; CYSTINYL AMINOPEPTIDASE; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; NITRIC OXIDE; OXYTOCIN; UMBILICAL VEINS; VASODILATOR AGENTS;

EID: 22244486673     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Coomarasamy A, Knox EM, Gee H, Khan KS: Oxytocin antagonists for tocolysis in preterm labour - a systematic review. Med Sci Monit, 2002 8(11): RA268-RA273
2. Gimpl G, Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol Rev, 2001; 81: 629-83
3. Kimura T, Tanizawa O, Mori K et al: Structure and expression of a human oxytocin receptor. Nature, 1992; 356: 526-29
4. Thibonnier M, Conarty DM, Preston JA et al: Erzurum SC. Human vascular endothelial cells express oxytocin receptors. Endocrinology, 1999; 140: 1301-9
5. Jankowski M, Wang D, Hajjar F et al: Oxytocin and its receptors are synthesized in the rat vasculature. Proc Natl Acad Sci USA, 2000; 97: 6207-11
6. Cassoni P, Sapino A, Fortuni N et al: Oxytocin inhibits the proliferation of MDA-MB231 human breast-cancer cells via cyclic adenocine monophosphate and protein kinase A. Int J Cancer, 1997; 72: 340-44
7. Novak JF, Judkins MB, Chernin MI et al: A plasmin-derived hexapeptide from the carboxyl end of osteocalcin counteracts oxytocin-mediated growth inhibition of osteosarcoma cells. Cancer Res, 2000; 60: 3470-76
8. Suzuki Y, Shibata K, Kikkawa F et al: Possible role of placental leucine aminopeptidase in the antiproloferative effect of oxytocin in human endometrial adenocarcinoma. Clin Cancer Res, 2003; 9: 1528-34
9. Tsujimoto M, Mizutani S, Adachi H et al: Identification of human placental leucine aminopeptidase as oxytocinase. Arch Biochem Biophys, 1992; 292: 388-92
10. Nagasaka T, Nomura S, Okamura M et al: Immunohistochemical localization of placental leucine aminopeptidase/oxytocinase in normal human placental, fetal and adult tissues. Reprod Fertil Develop, 1997; 9: 1-7
11. Rogi T, Tsujimoto M, Nakazato H et al: Human placental leucine aminopeptidase/oxytocinase J Biol Chem, 1996; 271: 56-61
12. Ross SA, Scott HM, Morris NJ et al: Characterization of the insulin-regulated membrane aminopeptidase in 3T3-L1 adipocytes. J Biol Chem, 1996; 271: 3328-32
13. Nakamura H, Itakura A, Okamura M et al: Oxytocin stimulate the translocation of oxytocinase of human vascular endothelial cells via activation of oxytocin receptors. Endocrinology, 2000; 141: 4481-85
14. Jaffe EA, Nachman RL, Becker CG, Minick CR: Culture of human endothelial cells derived from umbilical veins. J Clin Invest, 1973; 52: 2745-56
15. Ito M, Itakura A, Ohno Y et al: Possible activation of the renin-angiotensin system in the feto-placental unit in preeclampsia. J Clin Endocr Metab, 2002; 87: 1871-78
16. Iwase A, Nomura S, Mizutani S: Characterrization of a secretase activity for placental leucine aminopeptidase. Arch Biochem Biophys, 2001; 393: 163-69
17. Yamahara N, Nomura S, Suzuki T et al: Placental leucine aminopeptidase/oxytocinase in maternal serum and placenta during normal pregnancy. Life Sci, 2000; 21: 1401-10
18. Kimura T, Saji F: Molecular endocrinology of the oxytocin receptor. Endocr J, 1995; 42: 607-15
19. Tsukahara H, Ende H, Magazine HI et al: Molecular and functional characterization of the non-isopeptide-selective ETB receptor in endothelial cells. Receptor coupling to nitric oxide synthase. J Biol Chem, 1994; 269: 21778-85
20. Clementi E, Sciorati C, Riccio M et al: Nitric oxide action on growth factor-elicited signals. J Biol Chem, 1995; 270: 22277-82
21. Hariyama Y, Itakura A, Okamura M et al: Placental aminopeptidase A as a possible barrier of angiotensin II between mother and fetus. Placenta, 2000; 21: 621-27