An efficient synthesis of 2-(methylaminomethyl)-4,5-dialkyl-1H-imidazoles

Synlett

Volumn , Issue 10, 1998, Pages 1077-1078

  Reader, Valérie A ^a,b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b Cambridge Combinatorial Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 22244477656     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1998-1879     Document Type: Article

References (15)

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4. d) Jun, Y.; Thurkauf, A. WO 9625411 AI,
5. e) Kuzmierkiewicz, W. Pol. Acta Pol. Pharm., 1986, 43, 221-6,
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7. Hoff, D. R. Proc. Internat. Symp. on Drug Res., Montreal, Canada, 1967, p100.
8. Lipinski, C. A.; LaMattina, J. L.; Oates P. J. J. Med. Chem, 1986, 29, 2154-2163.
9. All comercially available compounds were bought from Aldrich Chemical Company, Inc.
10. Thioamide 5 has been synthesized by Culbertson, T. P.; Domagala, J. M.; Peterson, P.; Bongers, S.; Nichols, J. J. Heterocyclic Chem. 1987, 24, 1509-1520 using pyridine as the solvent.
11. 3), δ=2.90 (s, 3H, S-CH3)
12. Ley, S. V.; Norman, J.; Griffith, W. P.; Marsden, S. P. Synthesis, 1994, 639-666.
13. Borch, R. F.; Bernstein, M. D.; Durst, H. D. J. Am. Chem. Soc., 1971, 93, 2897-2904.
14. 3 of the imid.).
15. +.