Ultrashort electrical pulses open a new gateway into biological cells

Conference Record of the International Power Modulator Symposium and High Voltage Workshop

Volumn , Issue , 2004, Pages 205-209

  Schoenbach, K H ^a   Joshi, R P ^b   Kolb, J F ^a   Chen, N ^a   Stacey, M ^c   Buescher, E S ^c   Beebe, S J ^c   Blackmore, P ^c  

^a OLD DOMINION UNIVERSITY   (United States)

^b Eastern Virginia Medical School ^*  (United States)

^c EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CELL MEMBRANES; DNA; ELECTRIC CURRENTS; ELECTRIC POTENTIAL; FLUORESCENCE; GENES; GRANULAR MATERIALS; NUMERICAL METHODS; RNA; ULTRASHORT PULSES;

ELECTROPORATION; NANOSECOND PULSES; TIME CONSTANTS; ULTRASHORT ELECTRICAL PULSES;

ELECTRIC FIELD EFFECTS;

EID: 22244450718     PISSN: 10768467     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (17)

1. U. Zimmermann, "The Effect of High Intensity Electric Field Pulses on Eukaiyotic Cell Membranes: Fundamentals and Applications," in Electromanipulation of Cells, U. Zimmermann and G.A. Neil, Eds., CRC, Boca Raton, FL 1996, p. 1.
2. K.S. Cole, "Electric impedance of marine egg membranes," Trans Faraday Soc. 23, 966 (1937).
3. Karl H. Schoenbach, Ravindra P. Joshi, Juergen Kolb, Nianyong Chen, M. Stacey, P. Blackmore, E. Stephen Buescher, and Stephen J. Beebe, "Ultrashort Electrical Pulses Open a New Gateway into Biological Cells," Proc. IEEE 92, 1122 (2004).
4. R.P. Joshi, R.P., Q. Hu, and K. H. Schoenbach, "Modeling studies of cell response to ultrashort, high-intensity electric fields - implications for intracellular manipulation" IEEE Trans. Plasma Science, in press.
5. K.H. Schoenbach, S.J. Beebe, and E.S. Buescher, "Intracellular Effect of Ultrashort Electrical Pulses," Bioelectromagnetics 22, 440-448 (2001).
6. E.S. Buescher and K.H. Schoenbach, "Effects of Submicrosecond, High Intensity Pulsed Electric Fields on Living Cells - Intracellular Electromanipulation," IEEE Trans. Dielectrics and Electrical Insulation 10, 788-794 (2003).
7. N. Chen, K.H. Schoenbach, J. Kolb, A.L. Garner, J. Yang, J.R. Swanson, and S. Beebe, "Intracellular Effects of Nanosecond Electric Fields on Cells," BBRC 317, 421 (2004).
8. M. Stacey, J. Stickley, P. Fox, V. Statler, K.Schoenbach, S.J. Beebe, and S. Buescher, "Differential Effects in Cells Exposed to Ultra-Short, High Intensity Electric Fields: Cell Survival, DNA Damage, and Cell Cycle Analysis," Mutation Research 542, 65-75 (2003).
9. J. Deng, Schoenbach, K.H., Buescher, E.S., Hair, P.S., Fox, P.M., and Beebe, S.J., "The Effects of Intense Submicrosecond Electrical Pulses on Cells," Biophysical Journal 84, 2709-2714 (2003).
10. Stephen J. Beebe, Paula M. Fox, Laura J. Rec, E. Lauren K. Willis, and Karl H. Schoenbach, "Nanosecond, High Intensity Pulsed Electric Fields Induce Apoptosis in Human Cells," FASEB J. 17: 1493 (2003).
11. S.J. Beebe, P.M. Fox, L.J. Rec, K. Somers, R.H. Stark, and K.H. Schoenbach, "Nanosecond Pulsed electric Field (nsPEF) Effects on Cells and Tissues: Apopotosis Induction and Tumor Growth Inhibition," IEEE Trans. Plasma Science 30, 286-292 (2002).
12. Stephen J. Beebe, Jody White, Peter F. Blackmore, Yuping Deng, Kenneth Somers, and Karl H. Schoenbach, "Diverse Effects of Nanosecond Pulsed Electric Fields on Cells and Tissues," DNA and Cell Biology 22,785-796, (2003).
13. P.T. Vernier, A. Li, L. Marcu, C.M. Craft, and M.A. Gundersen, "Ultrashort Pulsed Electric Fields Induce Membrane Phospholipid Translocation and Caspase Activation: Differential Sensititivities of Jurkat T Lymphoblasts and Rat Glioma C6 Cells," IEEE Trans. Dielectrics and Electrical Insulation 10, 795 (2003).
14. Thomas Vernier, Yinghia Sun, Laura Marcu, Sarah Salemi, Cheryl M. Craft, and Martin A. Gundersen, "Calcium Bursts Induced by Nanosecond Electrical Pulses," BBRC 310, 286-295, (2003).
15. M. Behrend, A. Kuthi, X. Gu, P.T. Vernier, L. Marcu, and M.A. Gundersen, "Pulse Generators for Pulsed Electric Field Exposure of Biological Cells and Tissues," IEEE Trans. Dielectrics and Electrical Insulation 10, 820 (2003).
16. S.J. Beebe, P.M. Fox, L.J. Rec, K. Somers, R.H. Stark, and K.H. Schoenbach, "Nanosecond Pulsed electric Field (nsPEF) Effects on Cells and Tissues: Apopotosis Induction and Tumor Growth Inhibition," IEEE Trans. Plasma Science 30, 286-292 (2002).
17. Stephen J. Beebe, Peter F. Blackmore, Jody White, Ravindra P. Joshi, and Karl H. Schoenbach, "Nanosecond Pulsed Electric Fields Modulate Cell Function through Intracellular Signal Transduction Mechanisms," in press.