A new transgenic mouse model for the study of cell cycle control in megakaryocytes

Stem Cells

Volumn 14, Issue SUPPL. 1, 1996, Pages 181-187

  Thompson, Alexander ^a   Zhao, Zhuhui ^a   Ladd, Daniel ^a   Zimmet, Jeffrey ^a   Ravid, Katya ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

c myc; Cell cycle; Endomitosis; Megakaryocyte; Mice; Myeloid; Platelet factor 4; Polyploidization; Transgenic

Indexed keywords

ACETYLCHOLINESTERASE; CYCLIN A; CYCLIN D3; CYCLINE; ESTRADIOL; INTERLEUKIN 3; INTERLEUKIN 6; MESSENGER RNA; MYC PROTEIN; STEM CELL FACTOR;

ANIMAL; APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL CULTURE; CELL CYCLE; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL SURVIVAL; DOWN REGULATION; DRUG EFFECT; FEMALE; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MEGAKARYOCYTE; METABOLISM; MOUSE; NORTHERN BLOTTING; PHYSIOLOGY; PROMOTER REGION; TIME; TRANSGENIC MOUSE; UPREGULATION;

ACETYLCHOLINESTERASE; ANIMALS; APOPTOSIS; BLOTTING, NORTHERN; BONE MARROW CELLS; CELL CYCLE; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; CYCLIN A; CYCLINS; DOWN-REGULATION; ESTRADIOL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-3; INTERLEUKIN-6; MALE; MEGAKARYOCYTES; MICE; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-MYC; RNA, MESSENGER; S PHASE; STEM CELL FACTOR; TIME FACTORS; UP-REGULATION;

EID: 22244450411     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.5530140723     Document Type: Article

References (40)

1. Hartwell LH, Weinert TA. Checkpoints: controls that ensure the order of cell cycle events. Science 1989;246:629-634.
2. 3 is essential for megakaryocytopoiesis: the use of antisense oligonucleotides. Blood 1995;86:3783-3788.
3. Odell TT, Jackson CW Jr, Reiter RS. Generation cycle of rat megakaryocytes. Exp Cell Res 1968;53:321-327.
4. Smith AV, Orr-Wear TL. The regulation of the cell cycle during Drosophila embryogenesis: the transition to polyteny. Development 1991;112:997-1008.
5. Nasmyth KA. FAR-reaching discoveries about the regulation of START. Cell 1990;63:1117-1120.
6. Evans T, Rosenthal ET, Youngblom J et al. Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division. Cell 1983;33:389-396.
7. Westendorf JM, Swenson KI, Ruderman JV. The role of cyclin B in meiosis I. J Cell Biol 1990;108:1431-1444.
8. Pines J, Hunter T. Molecular cloning and characterization of the mRNA for cyclin from sea urchin eggs. EMBO J 1987;6:2987-2991.
9. Draetta G, Luca F, Westendorf J et al. Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF. Cell 1989;56:829-838.
10. King RW, Jackson PK, Kirschner MW. Mitosis in transition. Cell 1994;79:563-571.
11. Bartlett R, Nurse P. Yeast as a model system for understanding the control of DNA replication in eukaoryotes. Biossays 1990;10:457-463.
12. 1 phase in yeast. Proc Natl Acad Sci USA 1989;86:6255-6259.
13. 1-specific cyclins of S. cerevisiae: cell cycle periodicity, regulation by mating pheromone, and association with the p34CDC28 protein kinase. Cell 1990;62:225-237.
14. 1-specific cyclins: in search of an S-phase-promoting factor. Trends Genet 1991;7:95-99.
15. 1 phase in rodent fibroblasts. Genes Dev 1993;7:1559-1571.
16. Kiess M, Gill RM, Hamel PA. Expression of the positive regulator of cell cycle progression, cyclin D3, is induced during differentiation of myoblasts into quiescent myotubes. 1995;10:159-166.
17. Kelly K, Siebenlist U. The regulation and expression of c-myc in normal and malignant cells. Annu Rev Immunol 1986;4:317-338.
18. Cory S. Activation of cellular oncogenes in hemopoietic cells by chromosome translocation. Adv Cancer Res 1986;47:189-234.
19. Thompson A, Zhang Y, Ladd D et al. Female transgenic mice expressing PF4-myc-estrogen receptor fusion gene display alteration in megakaryocyte development. Blood 1995;86:284a.
20. Ravid K, Doi T, Beeler DL et al. Transcriptional regulation of the rat platelet factor 4 gene: interaction between an enhancer/silencer domain and the GATA site. Mol Cell Biol 1991;11:6116-6122.
21. Kuter DJ, Greenberg SM, Rosenberg RD. Analysis of megakaryocyte ploidy in rat bone marrow cultures. Blood 1989;74:1952-1957.
22. Ravid K, Li YC, Rayburn HB et al. Targeted expression of a conditional oncogene in hematopoietic cells of transgenic mice. J Cell Biol 1993;123:1545-1553.
23. Tamura K, Kanawoka Y, Jinno S et al. A new mammalian cyclin with homology to fission yeast Cig1. Oncogene 1993;8:2113-2118.
24. Eilers M, Picard D, Yamamoto K et al. Chimaeras of myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells. Nature 1989;340:66-68.
25. Doi T, Greenberg SM, Rosenberg RD. Structure of the rat platelet factor four gene: a marker for megakaryocyte differentiation. Mol Cell Biol 1987;7:898-904.
26. Jackson CW. Cholinesterase as a possible marker for early cells of the megakaryocytic series. Blood 1973;42:413-421.
27. Smith CA, Williams GT, Kingston R et al. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature 1989;337:181-184.
28. Vinci G, Tabilio A, Deschamps JF et al. Immunological study of in vitro maturation of human megakaryocytes. Br J Haematol 1984;56:589-605.
29. Hoang AT, Cohen KY, Barnett JF et al. Participation of cyclin A in myc-induced apoptosis. Proc Natl Acad Sci USA 1994;91:6875-6879.
30. Cole MD. The myc oncogene: its role in transformation and differentiation. Annu Rev Genet 1986;20:361-384.
31. Marcu KB, Bossone SA, Patel AJ. Myc function and regulation. Annu Rev Biochem 1992;61:809-860.
32. Rustgi A, Dyson N, Bernards R. Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product. Nature 1991;352:541-544.
33. Amin C, Wagner AJ, Hay N. Sequence-specific transcriptional activation by myc and repression by Max. Mol Cell Biol 1993;13:383-390.
34. Classon M, Henriksson M, Sumegi J et al. Elevated c-myc expression facilitates the replication of SV40 DNA in human lymphoma cells. Nature 1987;330:272-274.
35. Evan GI, Wyllie AH, Gilbert CS et al. Induction of apoptosis in fibroblasts by c-myc protein. Cell 1992;69:119-128.
36. Picard D, Salser SJ, Yamamoto K. A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor. Cell 1988;54:1073-1080.
37. Daksis JI, Lu RY, Facchini LM et al. Myc induces cyclin D1 expression in the absence of de novo protein synthesis and links mitogen-stimulated signal transduction to the cell cycle. Oncogene 1994;9:3635-3645.
38. Adams JM, Harris AW, Pinker CA et al. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 1985;318:533-538.
39. Bartlett PF, Reid HH, Bailey KA et al. Immortalization of mouse neural precursor cells by the c-myc oncogene. Proc Natl Acad Sci USA 1988;85:3255-3259.
40. Blasi E, Mathieson BJ, Varesio L et al. Selective immortalization of murine macrophages from fresh bone marrow by a raf/myc recombinant murine retrovirus. Nature 1985;318:667-670.