Role of lactate in critically ill children

Indian Journal of Critical Care Medicine

Volumn 8, Issue 3, 2005, Pages 173-181

  Agrawal, Shruti ^a   Sachdev, Anil ^a,b   Gupta, Dhiren ^a   Chugh, Krishan ^a  

^a SIR GANGA RAM HOSPITAL   (India)

^b NONE   (India)

Author keywords

Blood lactate levels; Glycolysis; Lactic acidosis; Sepsis; Shock

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BICARBONATE; CARBICARB; CATECHOLAMINE; CYANIDE; DICHLOROACETIC ACID; GLUCOSE; HYPERTENSIVE FACTOR; LACTIC ACID; TROMETAMOL;

ACUTE LUNG INJURY; ARTICLE; ARTIFICIAL VENTILATION; ASTHMA; BRAIN INJURY; CELL FUNCTION; CORRELATION ANALYSIS; CRITICAL ILLNESS; CYANIDE POISONING; DIALYSIS; DISEASE ASSOCIATION; GLUCONEOGENESIS; GLYCOLYSIS; HEART DISEASE; HEART SURGERY; HUMAN; HYDROLYSIS; HYPERLACTATEMIA; HYPOKALEMIA; HYPOXIA; LABORATORY TEST; LACTATE BLOOD LEVEL; LACTIC ACIDOSIS; LIVER FAILURE; LIVER INJURY; LUNG INJURY; METABOLIC ACIDOSIS; MITOCHONDRIAL RESPIRATION; OXIDATION REDUCTION REACTION; PATHOGENESIS; PEDIATRICS; PERFUSION; RESPIRATORY ALKALOSIS; SEPSIS; SEPTIC SHOCK; SHOCK;

EID: 22144479451     PISSN: 09725229     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Nimmo GR, Grant IS, Mackenzie SJ. Lactate and acid-base changes in the critically ill. Postgrad Med J 1991;67:56-61.
2. Mizock BA, Falk JL. Lactic acidosis in critical illness. Crit Care Med 1992;20:80-93.
3. Luft FC. Lactic Acidosis Update for Critical Care Clinicians. J Am Soc Nephrol 2001;12:15-9.
4. Broder G, Weil MH. Excess lactate: An index of reversibility of shock in human patients. Science 1964;143:1457-9.
5. Cowan BN, Burns HJG, Boyle P, et al. The relative prognostic value of lactate and hemodynamic measurements in early shock. Anesthesia 1985:39:750.
6. Cady LD, Weil HH, Afifi AA, et al. Quantitation of severity of critical illness with special reference to blood lactate. Crit Care Med 1973:1;73.
7. Weil MH, Michael S, Rackow EC. Comparison of blood lactate concentration in central vein, pulmonary artery and arterial blood. Crit Care Med 1987:15:489.
8. Mizock BA. The hepatosplanchnic area and hyperlactatemia: A tale of two lactates. Crit Care Med 2001;29:442-59.
9. Levraut J, Ciebiera JP, Chave S, Rabary O, Jambou P, Carles M, et al. Mild hyperlactatemia in stable septic patients is due to impaired lactate clearance rather than overproduction. Am J Respir Crit Care Med 1998;157:1021-6.
10. Levraut J, Ichai C, Petit I, Ciebierra JP, Perus O, Grimaud D. Low exogenous lactate clearance as an early predictor of mortality in normolactatemic critically ill septic patient. Crit Care Med 2003;31:705-10.
11. Stacpoole PW, Wright EC, Baumgartner TG, Bersin RM, Buchalter S, Curry SH, et al. Natural history and course of acquired lactic acidosis in adults. Am J Med 1994;97:47-54.
12. Gutierrez G, Wulf ME. Lactic acidosis in sepsis: A commentary. Intensive Care Med 1996:22;6-16.
13. Madias NE. Lactic Acidosis. Kidney Int 1986;29:752-74.
14. Duke T. Dysoxia and Lactate. Arch Dis Child 1999;81:343-50.
15. Laski ME, Wesson DE. Lactic Acidosis. In: Acid-Base and Electrolyte Disorders: A companion to Brenner and Rector's The Kidney. Dubose TD, Hamm LL, editors. Philadelphia: WB Saunders; 2000:83-107.
16. Slomovitz BM, Lavery RF, Tortella BJ, Siegel JH, Bachl BL, Ciccone A. Validation of hand held lactate device in determination of blood lactate in critically injured patients. Crit Care Med 1998;26:1523-8.
17. Aduen J, Bernstein WK, Khastgir T, Miller J, Kerzner R, Bhatiani A, et al. The use and clinical importance of a substrate specific electrode for rapid determination of blood lactate concentration. JAMA 1994;272:1678-85.
18. Toffaletti J, Hammes ME, Gray R, Lineberry B, Abrams B. Lactate measured in diluted and undiluted whole blood and plasma: Comparison of methods and effects of hematocrit. Clin Chem 1992;3B:2430-4.
19. Wiese J, Didwania A, Kernzer R, Chernow B. Use of different anticoagulants in test tubes for analysis of blood lactate concentrations. Crit Care Med 1997;25:1847-50.
20. Gunn VL, Nechyba C, editors. Missouri, Mosby: The Harriet Lane Handbook, 16th Ed.; 2002. p. 553.
21. Jackson EV, Wiese J, Sigal B, Miller J, Bernstein W, Kassel D, et al. Effects of crystalloid solutions on circulating lactate concentration. Crit Care Med 1997;25:1840-6.
22. Stacpoole PW, Wright WC, Baumgartner TG, Bersin RM, Buchalter S, Curry SH, et al. A controlled clinical trial of dichloroacetate for therapy of lactic acidosis in adults. N Engl J Med 1992;327:1564-9.
23. Stacpoole PW. Lactic Acidosis: The case against bicarbonate therapy. Ann Intern Med 1986;105:276-9.
24. Fraley DS, Adler S, Bruns FJ, Zett B. Stimulation of lactate production by administration of bicarbonate in a patient with a solid neoplasm and lactic acidosis. N Engl J Med 1980;303:1100-2.
25. Narins RG, Cohen JJ. Bicarbonate therapy for organic acidosis: The case for its continued use. Ann Intern Med 1987;106:615-8.
26. Bjemeroth G. Alkaline buffers for correction of metabolic acidosis during cardiopulmonary resuscitation with focus of tribonat. Resusc 1998;137:161-71.
27. Levraut J, Ciebierra JP, Jambou P, Ichai C, Labib Y, Grimaud D. Effect of continuous venovenous hemofiltration with dialysis on lactate clearance in critically ill patients. Crit Care Med 1997;25:58-62.
28. Vitek V, Cowley RA. Blood lactate in the prognosis of various forms of shock. Ann Surg 1971;41:989-1001.
29. Fowler AA, Hamman RF, Zerbe GO, Benson KN, Hyers TM. Adult Respiratory Distress Syndrome - Prognosis after onset. Am Rev Respir Dis 1985;132:472-8.
30. Maclean LD, Mulligan WG, Mclean APH, Duff JH. Patterns of septic shock in man - a detailed study of 56 patients. Ann Surg 1967;166:5-43.
31. DuBose TD. Acid Base Disorders. In: Brenner BM, editor. Brenner and Rector's The Kidney, 7th Ed. Philadelphia: WB Saunders; 2000. p. 925-97.
32. Mizock BA. Metabolic derangements in sepsis and septic shock. Crit Care Clin 2000;16:319-36.
33. Haji-Michael PG, Ladriere L, Sener A, Vincent JL, Malaisse WS. Leukocyte glycolysis and lactate output in animal sepsis and ex vivo human blood. Metabolism 1999;48:779-85.
34. Backer DD, Creteur J, Zhang H, Norrenberg M, Vincent JL. Lactate production by the lungs in acute lung injury. Am J Respir Crit Care Med 1997;156:1099-104.
35. Walsh TS, McLellan S, Mackenzie SJ, Lee A. Hyperlactatemia and pulmonary lactate production in patients with fulminant hepatic failure. Chest 1999;116:471-6.
36. Brinkmann A, Calzia E, Trager K. Monitoring the hepato-splanchnic region in the critically ill patient. Intensive Care Med 1998;24:542-56.
37. De Baker D, Creuter J, Noordally O, Nadia S, Beatrice G, Vincent JL. Does hepatosplanchnic VO/DO dependency exist in critically ill septic shock patients? Am J Respir Crit Care 1998;157:1219-25.
38. Bellomo R, Kellum JA, Pinsky MR. Transvisceral lactate fluxes during early endotoxemia. Chest 1996;110:198-204.
39. Backer DD, Creuter J, Silva E, Vincent JL. The hepatosplanchnic area is not a common source of lactate in patients with severe sepsis. Crit Care Med 2001;29:256-61.
40. Curtis SE, Cain SM. Regional and systemic oxygen delivery/uptake relations and lactate flux in hyperdynamic, endotoxin treated dogs. Am Rev Respir Dis 1992;145:348-54.
41. Douzinas EE, Tsiemiadou PD, Pitaridis MT, Andrinakis I, Bobota-Chloraki A, Katsouyami K, et al. The regional production of cytokines and lactate in sepsis-related multiple organ failure. Am J Respir Crit Care Med 1997;155:53-9.
42. Duke TD, Butt W, South M. Predictors of mortality and multiorgan failure in children with sepsis. Intensive Care Med 1997;33:684-92.
43. Hatherill M, Sajjanhar T, Tibby SM, Champion MP, Anderson D, Marsh DJ, et al. Serum lactate as a predictor of mortality after pediatric cardiac surgery. Arch Dis Child 1997;77:235-8.
44. Deshpande SA, Platt MPW. Association between blood lactate and acid base status and mortality in ventilated babies. Arch Dis Child 1997;76:15-20.
45. Yousef F, McGeady SJ. Lactic acidosis and status asthmaticus: How common in pediatrics. Ann Allergy Asthma Immunol 2002;89:585-8.
46. James JH, Luchette FA, McCarter FD, Fischer JE. Lactate as an unreliable indicator of tissue hypoxia in injury or sepsis. Lancet 1999;354:505-8.
47. Hatherill M, McIntyre G, Walter M, Murdoch IA. Early hyperlactatemia in critically ill children. Intensive Care Med 2000;26:314-8.
48. Perez A, Minces SA, Ciraolo CA, Schnitzler EJ, Agosta GE, Portillo Medina SA. Jugular venous oxygen saturation or arteriovenous difference of lactate content and outcome in children with severe traumatic brain injury. Pediatr Crit Care Med 2003;4:33-8.
49. Cormio M, Valadka AB, Robertson CS. Elevated jugular venous oxygen saturation after severe head injury. J Neurosurg 1999;90:9-15.
50. Murphy ND, Kodakat SK, Wendon JA, Jooste CA, Muiesan P, Rela M. Liver and intestinal lactate metabolism in patients with acute hepatic failure undergoing liver transplantation. Crit Care Med 2001;29:2111-8.
51. Mizock BA. Hyperlactatemia in acute liver failure: Decreased clearance vs. increased lactate production. Crit Care Med 2001;29:2225-6.
52. De Backer D, Creteur J, Zhang H, Norrenberg H, Vincent JL. Hyperlactatemia and pulmonary lactate production in patients with fulminant hepatic failure. Chest 1999;116:471-6.
53. Baud FJ, Borron SW, Megarbane B, Trout H, Tapostolle F, Vicant E, et al. Value of lactic acidosis in the assessment of the severity of acute cyanide poisoning. Crit Care Med 2002;30:2044-50.
54. Suistomaa M, Buokonen E, Kari M, Takala J. Time pattern of lactate and lactate to pyruvate ratio in the first 24 hours of intensive care emergency admissions. Shock 2000;14:8-12.
55. Levy B, Sadoune LO, Gelot AM, Bollaert PE, Nabet P, Larcan A. Evolution of lactate/pyruvate and arterial ketone body ratios in the early course of catecholamine treated septic shock. Crit Care Med 2000;28:114-9.
56. Hatherill M, Waggie Z, Perves L, Reynolds L, Argent A. Mortality and nature of metabolic acidosis in children with shock. Intensive Care Med 2000;26:314-8.