Effect of tamoxifen and raloxifene on cholesterol transformation to bile acids in ovariectomized rats

Gynecological Endocrinology

Volumn 20, Issue 6, 2005, Pages 313-316

  Czerny, Bogusław ^a   Pawlik, Andrzej ^a   Teister, Maria ^b   Juzyszyn, Zygmunt ^a   Myśliwiec, Zofia ^a  

^a POMERANIAN MEDICAL UNIVERSITY   (Poland)

^b MEDICAL UNIVERSITY OF SILESIA   (Poland)

Author keywords

Bile; Cholesterol; Selective estrogen receptor modulators

Indexed keywords

BILE ACID; CHENODEOXYCHOLIC ACID; CHOLESTEROL; CHOLIC ACID; DEOXYCHOLIC ACID; GLYCOCHENODEOXYCHOLIC ACID; GLYCOCHOLIC ACID; GLYCODEOXYCHOLIC ACID; LITHOCHOLIC ACID; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN; TAUROCHOLIC ACID;

ADOLESCENT; ANIMAL MODEL; ARTICLE; BILE ACID METABOLISM; BILE COMPOSITION; BILE FLOW; BONE METABOLISM; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSFORMATION; CONTROLLED STUDY; DRUG EFFECT; ESTROGEN DEFICIENCY; FEMALE; GALLSTONE FORMATION; ISOTOPE LABELING; LIPID METABOLISM; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; RADIOACTIVITY; RAT; THIN LAYER CHROMATOGRAPHY;

ANIMALS; BILE; BILE ACIDS AND SALTS; CHOLESTEROL; FEMALE; OVARIECTOMY; RALOXIFENE; RATS; RATS, WISTAR; SELECTIVE ESTROGEN RECEPTOR MODULATORS; TAMOXIFEN;

EID: 22144450681     PISSN: 09513590     EISSN: None     Source Type: Journal    
DOI: 10.1080/09513590500097861     Document Type: Article

References (16)

1. Nayfield SG, Kay JE, Forll LG, Dorr FA, Kramer BS. Potential role of tamoxifen in prevention of breast cancer. J Natl Cancer Inst 1991;83:1450-1459.
2. Genant HK, Lang T, Fuerst T, Pinette KV, Zhou C, Thiebaud D, Diez-Perez A. Treatment with raloxifene for 2 years increases vertebral bone mineral density as measured by volumetric quantitative computed tomography. Bone 2004;35:1164-1168.
3. Jordan VC. The secrets of selective estrogen receptor modulation: cell-specific coregulation. Cancer Cell 2002;1:215-217.
4. Czerny B, Pawlik A, Juzyszyn Z, Myśliwiec Z. Effect of tamoxifen on bone mineral density and blood lipids in ovariectomised rats. Pol J Pharmacol 2003;55:1137-1142.
5. Berard AM, Dumon MF, Darmon M. Dietary fish oil up-regulates cholesterol 7α-hydroxylase mRNA in mouse liver leading to an increase in bile acid and cholesterol excretion. FEBS Lett 2004;559:125-128.
6. 2-inhalation technique. J Biol Chem 1979;254:5252-5256.
7. Schwartz CC, Berman M, Vlahcevic ZR, Swell L. Multi-compartmental analysis of cholesterol metabolism in man: a quantitative kinetic evaluation of precursor sources and turnover of high density lipoprotein cholesterol esters. J Clin Invest 1982;70:864-876.
8. Pandak WM, Heuman DM, Hylemon PD, Vlahcevic ZR. Regulation of bile acid synthesis. IV. Interrelationship between cholesterol and bile acid biosynthesis pathways. J Lipid Res 1990;31:79-90.
9. Drover VA, Agellon LB. Regulation of the human cholesterol 7α-hydroxylase gene (CYP7A1) by thyroid hormone in transgenic mice. Endocrinology 2004;45:574-581.
10. Danielsson H, Kalles I, Lindstrom B, Lundell K, Wikvall K. Regulation of hydroxylation by biosynthesis of bile acids: modulation of reconstituted 12α-hydroxylase activity by proteins from rabbit cytosol and microsomes. Biochem Biophys Res Commun 1983;113:212-219.
11. Everson GT, McKinley C, Kern F Jr. Mechanisms of gallstone formation in women. Effects of exogenous estrogen (Premarin) and dietary cholesterol on hepatic lipid metabolism. J Clin Invest 1991;87:237-246.
12. Diehl AK. Epidemiology and natural history of gallstone disease. Gastroenterol Clin North Am 1991;20:1-219.
13. Uhler ML, Marks JW, Judd HL. Estrogen replacement therapy and gallbladder disease in postmenopausal women. Menopause 2000;7:162-167.
14. Honoré LH. Increased incidence of symptomatic cholesterol cholelithiasis in perimenopausal women receiving estrogen replacement therapy: a retrospective study. J Reprod Med 1980;25:187-190.
15. Paumgartner G, Sauerbruch T. Gallstones: pathogenesis. Lancet 1991;338:1117-1121.
16. Johnston DE, Kaplan MM. Pathogenesis and treatment of gallstones. N Engl J Med 1993;328:412-421.